Particle Surface Modification

Zarinwall, Ajmal; Waniek, Tassilo; Finke, Benedikt; Saadat, Reza; Sturm, Heinz; Garnweitner, Georg

doi:10.1007/978-3-030-68523-2_7

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Accordingly, reaction times of approximately 24 h for APTES and 48 h for TMCS are required to achieve a complete surface coverage since no further increase in the nitrogen and carbon content was observed for longer functionalization times. The obtained converging behavior indicates a complete occupation of all accessible binding sites under formation of a homogenous monolayer (Zarinwall et al., 2021; 2021b ) which is important for achieving the highest possible surface coverage. To specifically elucidate and evidence the nature of coordination, e.g.…”

Section: Resultsmentioning

confidence: 97%

Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels

et al. 2022

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Promising active pharmaceutical ingredients (APIs) often exhibit poor aqueous solubility and thus a low bioavailability that substantially limits their pharmaceutical application. Hence, efficient formulations are required for an effective translation into highly efficient drug products. One strategy is the preservation of an amorphous state of the API within a carrier matrix, which leads to enhanced dissolution. In this work, mesoporous silica aerogels (SA) were utilized as a carrier matrix for the amorphization of the poorly water-soluble model drug ibuprofen. Loading of tailored SA was performed post-synthetically and solvent-free, either by co-milling or via the melting method. Thorough analyses of these processes demonstrated the influence of macrostructural changes during the drying and grinding process on the microstructural properties of the SA. Furthermore, interfacial SA-drug interaction properties were selectively tuned by attaching terminal hydrophilic amino- or hydrophobic methyl groups to the surface of the gel. We demonstrate that not only the chemical surface properties of the SA, but also formulation-related parameters, such as the carrier-to-drug ratio, as well as process-related parameters, such as the drug loading method, decisively influence the ibuprofen adsorption efficiency. In addition, the drug-loaded SA formulations exhibited a remarkable physical stability over a period of 6 months. Furthermore, the release behavior is shown to change considerably with different surface properties of the SA matrix. Hence, the reported results demonstrate that utilizing specifically processed and modified SA offers a compelling technique for enhancement of the bioavailability of poorly-water soluble APIs and a versatile adjustment of their release profile.

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Section: Resultsmentioning

confidence: 97%

Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels

et al. 2022

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“…For details, the readers are referred to ref . Detailed cross-scale information on the boehmite/epoxy system can be found elsewhere. − Examples for nanocomposites based on thermoplastics and boehmite are discussed elsewhere. , …”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanocomposite Fibers of Polycarbonate- and Taurine-Modified Boehmite Nanoparticles: What Can Be Learned from Structural and Thermal Investigations?

Murillo

Szymoniak

Smales

et al. 2021

ACS Appl. Polym. Mater.

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Though the reinforcing properties of inorganic particles in thermosetting nanocomposites have been exploited, the integration of nanoparticles continues to be challenging in terms of their homogeneous distribution and their manipulation, which can contribute to occupational hazards. Due to second encapsulations of nanoparticles, electrospun nanocomposite fibers containing nanoparticles might be an alternative for overcoming these issues, as the nonwoven fibers contain nanoparticles allowing for safer manipulation. Here, the morphology and the thermal properties of electrospun polycarbonate fibers containing taurinemodified boehmite nanoparticles (BNPs) are investigated by means of small-and wide-angle X-ray scattering as well as fast scanning and temperature-modulated fast scanning calorimetry for the first time. The latter techniques allow the investigation of the thermal properties of single fibers at heating rates of up to 10 4 K s −1 keeping their structure intact. An analysis of the scattering data reveals a porous structure of the fibers. The porous structure is quantified regarding the pore volume and the pore size. A constant amount of aggregation is found even for the highly BNP-loaded fibers. Thermal analysis of the fibers reveals a rigid amorphous fraction (RAF), where it is known that the RAF determines the properties of a nanocomposite to a large extent. For the fibers, the RAF amounts up to 40 wt %, which is essentially higher compared to equally formulated PC/BNP composite cast films. The RAF, in the case of fibers, is not only due to the presence of particles in the polymer but also due to the orientation effects induced by the electrospinning process.

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Particle Surface Modification

Cited by 2 publications

References 49 publications

Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels

Amorphization and modified release of ibuprofen by post-synthetic and solvent-free loading into tailored silica aerogels

Electrospun Nanocomposite Fibers of Polycarbonate- and Taurine-Modified Boehmite Nanoparticles: What Can Be Learned from Structural and Thermal Investigations?

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