Particle size influence in an impaction bone grafting model. Comparison of fresh-frozen and freeze-dried allografts

Schubert, Thomas; Libouton, Xavier; Manil, Olivier; Godts, Bernard; Tomme, John Van; Banse, Xavier; Delloye, Christian

doi:10.1016/j.jbiomech.2009.06.045

Cited by 27 publications

(33 citation statements)

References 18 publications

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“…10,11,23 These results have been reproduced in long-term clinical series, where acetabular grafting with large particles has demonstrated superior survival rates compared to grafting with small slurry bone grafts (such as that obtained with acetabular reaming). [24][25][26][27][28] The aim of the current study was to compare the yield of graft obtained through differing preparation methods as well as assess the compressibility of both preparation methods.…”

Section: Discussionmentioning

confidence: 82%

Efficient use of a limited resource: A comparison of femoral head allograft preparation methods

Marshall

Chow

Sivakumar

et al. 2017

Journal of Orthopaedic Surgery

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Purpose: The purpose of the study was to compare the yield and compressed volume of femoral head allograft prepared by either hand morselization or a bone mill. Methods: Twenty human femoral head allografts were donated from a bone bank and morselized by two different methods. The heads were divided in half and split into two sample groups. One group underwent hand morselization with large bone nibblers, while the other was prepared using a bone mill. The volume of graft produced was measured. Ten-gram aliquots of each sample then underwent 30 impactions in a contained cavity, with the volume of graft compression measured. Results: Bone milling yielded approximately 31% more usable graft than hand morselization (81% to 50%; p ¼ 0.0001). There was no difference between the compressed volume of graft prepared by either method (p ¼ 0.14). Conclusion: This study demonstrates the efficacy of preparation of allograft with a bone mill and assists the clinician in determining the yield of graft by the weight of femoral head, thereby potentially minimizing excessive ordering and wastage.

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Section: Discussionmentioning

confidence: 82%

Efficient use of a limited resource: A comparison of femoral head allograft preparation methods

Marshall

Chow

Sivakumar

et al. 2017

Journal of Orthopaedic Surgery

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“…This chemical treatment ensures defatting, prion, virus and bacterial inactivation as well as decellularization [13, 14]. …”

Section: Methodsmentioning

confidence: 99%

Enhanced Vascular Biocompatibility and Remodeling of Decellularized and Secured Xenogeneic/Allogeneic Matrices in a Porcine Model

et al. 2018

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Background/Purpose: Calcifications and absence of growth potential are the major drawbacks of glutaraldehyde-treated prosthesis. Decellularized and secured xeno-/allogeneic matrices were assessed in a preclinical porcine model for biocompatibility and vascular remodeling in comparison to glutaraldehyde-fixed bovine pericardium (GBP; control). Methods: Native human (fascia lata, pericardium) and porcine tissues (peritoneum) were used and treated. In vitro, biopsies were performed before and after treatment to assess decellularization (hematoxylin and eosin/DAPI). In vivo, each decellularized and control tissue sample was implanted subcutaneously in 4 mini-pigs. In addition, 9 mini-pigs received a patch or a tubularized prosthesis interposition on the carotid artery or abdominal aorta of decellularized (D) human fascia lata (DHFL; n = 4), human pericardium (DHP; n = 9), porcine peritoneum (DPPt; n = 7), and control tissue (GBP: n = 3). Arteries were harvested after 1 month and subcutaneous samples after 15–30 days. Tissues were processed for hematoxylin and eosin/von Kossa staining and immunohistochemistry for CD31, alpha-smooth muscle actin, CD3, and CD68. Histomorphometry was achieved by point counting. Results: A 95% decellularization was confirmed for DHP and DPPt, and to a lower degree for DHFL. In the subcutaneous protocol, CD3 infiltration was significantly higher at day 30 in GBP and DHFL, and CD68 infiltration was significantly higher for GBP (p < 0.05). In intravascular study, no deaths, aneurysms, or pseudoaneurysms were observed. Inflammatory reaction was significantly higher for DHFL and GBP (p < 0.05), while it was lower and comparable for DHP/DPPt. DHP and DPPt showed deeper recellularization, and a new arterial wall was characterized. Conclusions: In a preclinical model, DPPt and DHP offered better results than conventional commercialized GBP for biocompatibility and vascular remodeling.

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“…FDBA is generally extracted from live healthy donors undergoing orthopedic surgery of the hip. Freezedrying process markedly reduces the health risks associated with fresh frozen bone [19].…”

Section: Mineralized Freeze-dried Bone Allografts (Fdba)mentioning

confidence: 99%

Current Knowledge and Future Perspectives of Bone Replacement Grafts

Kassir¹,

Chakar²

2018

IAJD

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Bone and periodontal regenerative procedures represent a fundamental component of periodontal practice. While autologous bone graft has always been considered the ideal material for the repair and/or reconstruction of craniofacial defects, its limited availability and harvesting-associated complications and discomfort lead to a substantial interest in bone replacement grafts (BRG) throughout the years. With increasing technological advances and understanding, the spectrum of BRG has broadened and taking into consideration that not all BRM perform in the same way, the appropriate clinical choice needs to be performed among the large varieties of available biomaterials. Because an understanding of the properties of each BRG enables individualized clinical selection, the objective of this article is to provide a review on the different types of BRG intended for reconstructive therapy and provide an overview on the current innovations and future perspectives in this field.

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Particle size influence in an impaction bone grafting model. Comparison of fresh-frozen and freeze-dried allografts

Cited by 27 publications

References 18 publications

Efficient use of a limited resource: A comparison of femoral head allograft preparation methods

Efficient use of a limited resource: A comparison of femoral head allograft preparation methods

Enhanced Vascular Biocompatibility and Remodeling of Decellularized and Secured Xenogeneic/Allogeneic Matrices in a Porcine Model

Current Knowledge and Future Perspectives of Bone Replacement Grafts

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