Particle size dependence of relaxivity for silica-coated iron oxide nanoparticles

Ahmad, Tanveer; Bae, Hongsub; Rhee, Ilsu; Chang, Yongmin; Lee, Jaejun; Hong, Sungwook

doi:10.1016/j.cap.2011.12.020

Cited by 38 publications

(16 citation statements)

References 25 publications

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“…The r 2 /r 1 value for dextrin-coated IFNPs is higher than r 2 /r 1 for all materials except Resovist. The relaxivity ratio (r 2 /r 1 ) increases with increasing particle size [49,50]. Therefore, Resovist (60 nm) [48], dextranstabilized SPIONs (50 nm) [51], and citrate-coated iron oxide nanoparticles (30 nm) [52] have a higher r 2 /r 1 ratio, compared with dextrin-coated IFNPs.…”

Section: Phantom Studiesmentioning

confidence: 96%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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Iron oxide nanoparticles, such as ferrites, offer some attractive possibilities in biomedicine, especially in MRI applications. The objective of this study is to investigate the effectiveness of dextrin-coated zinc-iron ferrite nanoparticles (IFNPs) as an MRI contrast agent in in vivo and in vitro media. IFNPs were synthesized by an aqueous precipitation method in the presence of dextrin. An agarose phantom with different concentrations of dextrin-coated IFNPs was performed on a 1.5-T MRI. For in vivo MRI studies, implanted melanoma tumors in mice were immediately scanned after intra-tumoral injection of dextrincoated IFNPs. Microscopic studies showed that the average diameter of dextrin-coated IFNPs was 12 ± 2.4 nm and the saturation magnetization for IFNPs was 31.5 emu g -1 ; r 1 and r 2 relaxivities of these ultrasmall superparamagnetic IFNPs in agarose phantom were obtained as 0.99 and 17.4 mmol L -1 s -1 , respectively. The relaxivity measurements revealed that the dextrin-coated IFNPs can serve as a negative contrast agent. In vivo MRI showed that the dextrin-coated IFNPs can be used for tumor detection. The dextrin-coated IFNPs were suggested to be applied for lymph node and targeted imaging.

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Section: Phantom Studiesmentioning

confidence: 96%

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

et al. 2015

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“…Various inorganic and organic materials such as silica, gold, polyethylene glycol (PEG) and dextran have been employed for the coating of the Fe 3 O 4 NPs [12]. The most common method is a Solegel method in which silica is coated with tetraethyl orthosilicate (TEOS) employed as a precursor, which is a well-known St€ ober process [13,14]. The SiO 2 -coated coreeshell structured NPs are well separated, chemically stable, and nontoxic.…”

Section: Introductionmentioning

confidence: 99%

Magnetic properties of SiO2-coated iron oxide nanoparticles studied by polarized small angle neutron scattering

Lee

Jung

et al. 2015

Current Applied Physics

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“…In general, the synthesis of silica coated MNPs mainly includes sol-gel process, microemulsion synthesis, and the aerosol pyrolysis method [2], [3]. Among these methods, the sol-gel process offers several advantages, including low cost, relatively mild reaction [4], high purity, and good homogeneity.…”

Section: Introductionmentioning

confidence: 99%

Linear Birefringence and Dichroism Measurements for Silica Coated Iron Oxide Ferrofluids

et al. 2014

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The core-shell structural SiO Fe O nanocomposites were prepared via hydrolysis and condensation of tetraethyl orthosilicate (TEOS) by using iron oxide nanoparticles as seeds in a 2-propanol/distilled water mixed solvent using ammonia as catalyst. The waterbased ferrofluid (FF) as 0.3 ml EMG 304 was adopted as the seed. The effects of ammonia aqueous amount, volume ratio of 2-propanol/ distilled water, TEOS amount, and reaction time on size and dispersibilty are investigated via transmission electron microscope and X-ray diffraction. Further, the linear birefringence and dichroism measurements of silica coated FF were investigated by a Stokes polarimeter. Results indicated that the appropriate reaction parameters including volume ratio of 2-propanol/distilled water of 5:1, ammonia solution volume of 0.5 ml, TEOS amount of 50 mg, and mechanical stirring of 1000 r/min for 3 h were found to obtain large retardance and low dichroism.

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Particle size dependence of relaxivity for silica-coated iron oxide nanoparticles

Cited by 38 publications

References 25 publications

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

Synthesis, characterization, in vitro and in vivo studies of dextrin-coated zinc-iron ferrite nanoparticles (Zn0.5Fe0.5Fe2O4) as contrast agent in MRI

Magnetic properties of SiO2-coated iron oxide nanoparticles studied by polarized small angle neutron scattering

Linear Birefringence and Dichroism Measurements for Silica Coated Iron Oxide Ferrofluids

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