“…In addition, compared with the ultrasonic bath, the ultrasonic horn has a stronger cavitation effect, and thus the crystal prepared using the ultrasonic horn has better properties. Chang et al 58 found that probenecid crystals prepared by conventional cooling crystallization were in a disordered needle-like state, while after ultrasonic treatment, regular rod-like probenecid crystals with a small crystal size and narrow particle size distribution were obtained. Under the same cooling rate and ultrasonic conditions, the particle size of probenecid crystals could be increased from 9.4 μm to 15.3 μm, as the solution concentration increased from 45 mg mL −1 to 90 mg mL −1 .…”