Particle Manipulation Methods in Droplet Microfluidics

Tenje, Maria; Fornell, Anna; Ohlin, Mathias; Nilsson, Johan

doi:10.1021/acs.analchem.7b01333

Cited by 45 publications

(34 citation statements)

References 86 publications

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“…Indeed, we could argue that a proper evaluation of electrokinetics of metals requires combination with independent monopolar electrochemical measurements from which the bipolar electrodic determinants of the electron transfer reaction rates can be derived under given electrokinetic measurement conditions, such as the strength of the DC field across the bulk liquid medium. Subsequently, it can be decided whether or not these faradaic reactions interfere with streaming potential generation and [65][66][67], and for the spatially-resolved detection of electroactive analytes in sensor devices whose functioning calls for bipolar electrochemistry principles.…”

Section: Discussionmentioning

confidence: 99%

Coupling between electrokinetics and electrode kinetics by bipolar faradaic depolarisation processes in microfluidic channels

Duval

Leeuwen

2020

Advances in Colloid and Interface Science

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This article is concerned with the nature and impact of bipolar faradaic electron transfer processes in the context of measuring electrokinetic parameters at the interface between an electronically conductive substrate such as a solid metal layer, and a liquid medium. More specifically, it analyses the steady state electric current through the electrodic substrate layer in terms of its short-circuiting effect on the system's electrokinetic quantities, such as the streaming potential. Ample attention is paid to the electrodic behaviour of the chosen metal and its electron transfer characteristics with respect to redox functions in the medium. The electrochemical reversibility of redox couple species is expressed in terms of their oxidation and reduction rate constants as compared to their diffusive transport rates under lateral flow conditions. High values for rate constants lead to high reversibilities and large bipolar leaking currents through the metal substrate. In turn, high electron transfer rate constants generate large reductions in measured values for electrokinetic quantities such as streaming potentials that become a non-linear function of the pressure gradient applied through the fluidic chamber. The present article presents an overview of theoretical and experimental approaches of this intricate coupling between bipolar electrode kinetics and electrokinetics and the impact from Hans Lyklema's contributions. It highlights not only the implications of bipolar faradaic depolarisation processes in electrokinetics but also the importance of bipolar electrochemistry principles in various electroanalytical applications reported for e.g. the control of microfluidic flows, for surfaces functionalisation, particles manipulation or for the wireless detection of electroactive analytes.

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Section: Discussionmentioning

confidence: 99%

Coupling between electrokinetics and electrode kinetics by bipolar faradaic depolarisation processes in microfluidic channels

Duval

Leeuwen

2020

Advances in Colloid and Interface Science

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“…Generally, the produced droplets were applied as self‐contained and flexible microreactors in many fields. In order to the meet the utilization requirements and to promote utilization efficiency, the actuation of generated droplets in microfluidics is necessary . Methods for manipulation of droplets was divided into the passive and the active methods.…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

“…In order to the meet the utilization requirements and to promote utilization efficiency, the actuation of generated droplets in microfluidics is necessary. [99] Methods for manipulation of droplets was divided into the passive and the active methods. External conditions, such as mechanical, magnetic, thermal, electric, gravity, acoustic and optical stimuli, have been employed to manipulate droplets to perform various behaviors, such as splitting, coalescence, sorting, trapping, mixing, migrating and so on.…”

Section: Microfluidics For the Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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117

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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“…Many enrichment methods such as electromagnetics, 10 hydrodynamics, 11,12 biochemistry 13 and acoustics 14 to handle particles encapsulated inside droplets or manipulate whole droplets have been reported, and the advantages and disadvantages of these different techniques are discussed to guide new users. 15 Among them, the acoustic method does not need the specic electromagnetic characteristics of the sample, nor does it need special markers, and the damage to the sample is also negligible. The popular and traditional method of acoustic manipulation of samples, especially particles, is to use standing or traveling surface acoustic waves (SAW) to pattern, 16 sort 17 or capture.…”

Section: Introductionmentioning

confidence: 99%