Particle in cell simulation of laser‐accelerated proton beams for radiation therapy

Fourkal, E; Shahine, Bilal; Ding, M.; Li, J. S.; Tajima, T.; Ma, C

doi:10.1118/1.1521122

Cited by 164 publications

(103 citation statements)

References 34 publications

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“…This interaction was also thoroughly studied using 2D and 3D particle-in-cell computer simulations, which show that by optimizing the parameters of the laser pulse and the target it is possible to obtain protons with an energy of several hundreds of MeV [5][6][7]. The numerical and experimental studies suggest that proton therapy using compact laser systems may be practical [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Accelerating protons to therapeutic energies with ultraintense, ultraclean, and ultrashort laser pulses

et al. 2008

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Proton acceleration by high-intensity laser pulses from ultra-thin foils for hadron therapy is discussed. With the improvement of the laser intensity contrast ratio to 10 laser pulse propagation enhancing the longitudinal charge separation electric field that accelerates light ions. The dependence of the maximum proton energy on the foil thickness has been found and the laser pulse characteristics have been matched with the thickness of the target to ensure the most efficient acceleration. Moreover the proton spectrum demonstrates a peaked structure at high energies, which is required for radiation therapy. 2D PIC simulations show that a 150-500 TW laser pulse is able to accelerate protons up to 100-220 MeV energies.

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Section: Introductionmentioning

confidence: 99%

Accelerating protons to therapeutic energies with ultraintense, ultraclean, and ultrashort laser pulses

et al. 2008

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“…This is because the laser-driven energetic ions show many peculiar characteristics compared with those of the ion beams from conventional accelerators [70,71], thus many potential fields of applications are proposed, including medical application [72][73][74]. For the medical applications, there still exist many issues which we have to overcome.…”

Section: Laser-accelerated Protons From Thin Foilsmentioning

confidence: 99%

Ultra-Intense, High Spatio-Temporal Quality Petawatt-Class Laser System and Applications

et al. 2013

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This paper reviews techniques for improving the temporal contrast and spatial beam quality in an ultra-intense laser system that is based on chirped-pulse amplification (CPA). We describe the design, performance, and characterization of our laser system, which has the potential for achieving a peak power of 600 TW. We also describe OPEN ACCESSAppl. Sci. 2013, 3 215 applications of the laser system in the relativistically dominant regime of laser-matter interactions and discuss a compact, high efficiency diode-pumped laser system.

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“…Groups in several countries are working on proton laser acceleration; [36][37][38] however, because of the technical difficulties, it is not expected that the current development efforts will be able to achieve the required beams even for treatment of ocular melanomas ͑ϳ70 MeV at a dose rate of approximately 10-12 Gy/ min͒ over the next 5 -7 years.…”

Section: Ivc2c Laser Accelerationmentioning

confidence: 99%

Vision : Proton therapy

2009

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The first patients were treated with proton beams in 1955 at the Lawrence Berkeley Laboratory in California. In 1970, proton beams began to be used in research facilities to treat cancer patients using fractionated treatment regimens. It was not until 1990 that proton treatments were carried out in hospital-based facilities using technology and techniques that were comparable to those for modern photon therapy. Clinical data strongly support the conclusion that proton therapy is superior to conventional radiation therapy in a number of disease sites. Treatment planning studies have shown that proton dose distributions are superior to those for photons in a wide range of disease sites indicating that additional clinical gains can be achieved if these treatment plans can be reliably delivered to patients. Optimum proton dose distributions can be achieved with intensity modulated protons ͑IMPT͒, but very few patients have received this advanced form of treatment. It is anticipated widespread implementation of IMPT would provide additional improvements in clinical outcomes. Advances in the last decade have led to an increased interest in proton therapy. Currently, proton therapy is undergoing transitions that will move it into the mainstream of cancer treatment. For example, proton therapy is now reimbursed, there has been rapid development in proton therapy technology, and many new options are available for equipment, facility configuration, and financing. During the next decade, new developments will increase the efficiency and accuracy of proton therapy and enhance our ability to verify treatment planning calculations and perform quality assurance for proton therapy delivery. With the implementation of new multi-institution clinical studies and the routine availability of IMPT, it may be possible, within the next decade, to quantify the clinical gains obtained from optimized proton therapy. During this same period several new proton therapy facilities will be built and the cost of proton therapy is expected to decrease, making proton therapy routinely available to a larger population of cancer patients.

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Particle in cell simulation of laser‐accelerated proton beams for radiation therapy

Cited by 164 publications

References 34 publications

Accelerating protons to therapeutic energies with ultraintense, ultraclean, and ultrashort laser pulses

Accelerating protons to therapeutic energies with ultraintense, ultraclean, and ultrashort laser pulses

Ultra-Intense, High Spatio-Temporal Quality Petawatt-Class Laser System and Applications

Vision : Proton therapy

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