Particle formation by turbulent mixing with supercritical antisolvent

Henczka, Marek; Bałdyga, J.; Shekunov, Boris Y.

doi:10.1016/j.ces.2004.11.015

Cited by 48 publications

(24 citation statements)

References 8 publications

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“…Henczka et al 11 studied numerically the supercritical antisolvent precipitation of paracetamol with carbon dioxide as antisolvent. Mass, momentum, and energy balances to take into account the heat of mixing in the studied system were solved with the commercial CFD code FLUENT(R).…”

Section: Introductionmentioning

confidence: 99%

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

et al. 2011

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in Wiley Online Library (wileyonlinelibrary.com).Supercritical fluids have been extensively used for particle production of many natural and pharmaceutical substances providing useful alternatives for pharmaceutical and nutraceutical particulate system formulation. Among the different methods, the gas or supercritical antisolvent (GAS or SAS) process and its variants, have received a considerable interest due to the wide range of materials that can be micronized. Controlling particle formation in order to nucleate small particles is a key issue in GAS and SAS processes and this is directly related to mixing at all scales. In this work, we focus on numerical simulation of the process, emphasizing mixing modeling. Different mixing devices characterized by different nozzles are analyzed, to get an insight into mixing dynamics and its influence on the final particle size distribution. Results show that mixing is determinant in obtaining smallCorrespondence concerning this article should be addressed to J. Sierra-Pallares at jsierra@cfd1.eis.uva.es.

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Section: Introductionmentioning

confidence: 99%

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

et al. 2011

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“…Based on a non-isothermal approach coupled with a PBE and comparing with experimental data, Henczka and Shekunov (2005) pointed out the importance and better accuracy of models to predict particles sizes that consider the micro-mixing when compared to simulations that do not consider this physical process.…”

Section: Introductionmentioning

confidence: 99%

The Effect of System Temperature and Pressure on the Fluid-Dynamic Behavior of the Supercritical Antisolvent Micronization Process: A Numerical Approach

Almeida

Rezende

Cabral

et al. 2016

Braz. J. Chem. Eng.

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-The Supercritical Antisolvent (SAS) technique allows for the precipitation of drugs and biopolymers in nanometer size in a wide range of industrial applications, while guaranteeing the physical and chemical integrity of such materials. However, a suitable combination of operating parameters is needed for each type of solute. The knowledge of fluid dynamics behavior plays a key role in the search for such parameter combinations. This work presents a numerical study concerning the impact of operating temperature and pressure upon the physical properties and mixture dynamics within the SAS process, because in supercritical conditions the radius of the droplets formed exhibits great sensitivity to these variables. For the conditions analyzed, to account for the heat of mixture in the energy balance, subtle variations in the temperature fields were observed, with almost negligible pressure drop. From analyses of the intensity of segregation, there is an enhancement of the mixture on the molecular scale when the system is operated at higher pressure. This corroborates experimental observations from the literature, related to smaller diameters of particles under higher pressures. Hence, the model resulted in a versatile tool for selecting conditions that may promote a better control over the performance of the SAS process.

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“…Previsões obtidas com modelos são valiosas para entender o comportamento do processo em escala de nível industrial. Henczka et al (2005) estudaram numericamente o antissolvente supercrítico na precipitação de paracetamol com dióxido de carbono como antissolvente. Levaram em conta o calor da mistura no sistema estudado.…”

Section: Introductionunclassified

Influência Da Pressão E Da Temperatura Na Velocidade Do Jato De Um Escoamento Turbulento 3d

Cardoso¹,

Almeida²,

Rezende³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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Particle formation by turbulent mixing with supercritical antisolvent

Cited by 48 publications

References 8 publications

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

A computational fluid dynamics study of supercritical antisolvent precipitation: Mixing effects on particle size

The Effect of System Temperature and Pressure on the Fluid-Dynamic Behavior of the Supercritical Antisolvent Micronization Process: A Numerical Approach

Influência Da Pressão E Da Temperatura Na Velocidade Do Jato De Um Escoamento Turbulento 3d

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