PARTICIPATION OF TRANSCRIPTIONAL FACTORS E2F1 AND p73 IN THE DEVELOPMENT OF DOXORUBICIN RESISTANCE IN THE TUMOROUS CELLS THP-1 INFECTED WITH HUMAN CYTOMEGALOVIRUS

Emelyanova, S. S.; Chernoryzh, Ya. Yu.; Yurlov, K.I.; Федорова, Н. Е.; Иванов, А. В.; Kochetkov, Sergey N.; Verbenko, V. N.; Кущ, А А; Vinogradskaya, G. R.

doi:10.31116/tsitol.2018.07.07

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Section: Cytomegalovirus Can Decrease the Chemotherapy Sensitivity By...mentioning

confidence: 99%

“…In some cases, HCMV can change the balance between the tumor suppressor and carcinogenic p73 isoforms, and a predominance of the truncated isoforms facilitates the anticancer drug resistance [ 113 – 115 ]. HCMV infection was observed to activate the molecular pathways that induce expression of the E2F1 transcription factor [ 115 ], which is capable of both activating and inhibiting p73 [ 116 ]. The truncated p73 isoforms prevent TAp73-dependent transcription of miR-205, which controls the E2F1 accumulation and acts as a negative regulator of the BCL2 antiapoptotic protein and the ATP-binding cassette transporters ABCA-2 and ABCA-5, which are responsible for elimination of cytotoxic anticancer agents from the cell [ 117 , 118 ].…”

Section: Cytomegalovirus Can Decrease the Chemotherapy Sensitivity By...mentioning

confidence: 99%

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Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells

2022

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Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and tumor progression. HCMV proteins were shown to regulate the key processes involved in tumorigenesis. While HCMV as an oncogenic factor just came into focus, its ability to promote tumor progression is generally recognized. The review discusses the viral factors and cell molecular pathways that affect the resistance of cancer cells to therapy. CMV inhibits apoptosis of tumor cells, that not only promotes tumor progression, but also reduces the sensitivity of cells to antitumor therapy. Autophagy was found to facilitate either cell survival or cell death in different tumor cells. In leukemia cells, HCMV induces a “protective” autophagy that suppresses apoptosis. Viral factors that mediate drug resistance and their interactions with key cell death pathways are necessary to further investigate in order to develop agents that can restore the tumor sensitivity to anticancer drugs.

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