Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat

Dantas, Bruna Priscilla Vasconcelos; Alves, Quiara Lovatti; Assis, Kívia S.; Ribeiro, Thais Porto; Almeida, Mônica Moura de; Vasconcelos, Aliny Pereira de; Araújo, Demétrius Antônio Machado de; Braga, Valdir de Andrade; Medeiros, Isac A.; Alencar, Jacicarlos Lima de; Silva, Darízy Flávia

doi:10.1016/j.vph.2015.02.016

Cited by 34 publications

(58 citation statements)

References 62 publications

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“…Carvacrol, a monoterpene of natural origin, induces vasorelaxation in isolated vessels from rat, observed on mesenteric arteries, mainly through an inhibition of calcium influx, with a participation of the TRP channels. [6] Previous studies on smooth muscle and vascular beds also reported vasoactive profile for this monoterpene, as well as a dosedependent hypotension and bradycardia on anaesthetized rats. [5,7] In this study, we focused on the endothelium-dependent vascular effect of the monoterpene; indeed, in preparations with intact endothelium, carvacrol produced more potent vasorelaxation on the 20 mM KCl-precontracted aortae than in preparations without endothelium (Figure 1; Tab 1), suggesting a relevant contribution of some mediators of endothelial origin in its vascular effects.…”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 89%

“…Moreover, this monoterpene is reported to exhibit vasorelaxing activity on rat isolated aorta and more recently on rat mesenteric arteries . Indeed, when administered intraperitoneal to normotensive rats, carvacrol induced hypotensive responses .…”

Section: Introductionmentioning

confidence: 97%

“…[1][2][3][4] Moreover, this monoterpene is reported to exhibit vasorelaxing activity on rat isolated aorta [5] and more recently on rat mesenteric arteries. [6] Indeed, when administered intraperitoneal to normotensive rats, carvacrol induced hypotensive responses. [7] Although Peixoto-Neves et al hypothesized the involvement of calcium channels in the concentration-dependent reduction in KCl-or phenylephrine-induced contractions, presently no clear mechanism of action has been assigned.…”

Section: Introductionmentioning

confidence: 99%

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Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta

Testai

Chericoni

Martelli

et al. 2016

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta

Testai

Chericoni

Martelli

et al. 2016

Journal of Pharmacy and Pharmacology

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“…Intra-aortic pressure was recorded using a technique described by Dantas et al [15] In rats anesthetized with sodium thiopental (45 mg/kg, i.v. ), the lower abdominal aorta and inferior vena cava were cannulated via the left femoral artery and vein using polyethylene catheters.…”

Section: Methodsmentioning

confidence: 99%

Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze DriedSyzygium jambolanum(Lam.) DC Fruit Juice

Assis

Araújo

Azevedo

et al. 2018

BioMed Research International

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This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induces hypotension and vasodilatation in mesenteric arteries, with or without vascular endothelium. JSJ-mediated vasodilation response against contractions induced with KCl (60 mM) depolarizing solution was significantly lower than the responses induced by JSJ when evaluated against phenylephrine-induced contractions. To investigate the involvement of potassium channels we used Tyrode's solution with KCl (20 mM) or tetraethylammonium (1.0, 3.0, or 5.0 mM). In these conditions JSJ-induced effects were significantly attenuated. To investigate the potassium channel subtypes involved in the response, we used 4-aminopyridine, glibenclamide, BaCl2, and iberiotoxin. In the presence (simultaneous) of different potassium channel blockers we observed a significant attenuation of JSJ-induced effect. Inhibition was also observed when using BaCl2, glibenclamide, or 4-aminopyridine, separately. However, incubation with iberiotoxin did not promote changes in either maximum effect, or potency. We also evidenced a discrete participation of CaV channels in the JSJ-induced vasorelaxant effect. In addition, patch-clamp studies demonstrated that JSJ could activate potassium channels. In conclusion, JSJ promotes hypotension and vasorelaxation in rats, involving, at least, the activation of potassium channels.

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A descriptive review on exploiting the therapeutic significance of essential oils as a potential nutraceutical and food preservative

Jan,

Choudhary,

Malik

et al. 2024

Food Safety and Health

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For centuries, essential oils (EOs) have held a significant place in traditional medicinal practices worldwide and are commonly known for their aroma and taste. Among the 3000 recognized types, only 300 have commercial use in the food and pharmaceutical sectors. These potent natural extracts, derived from aromatic plants and herbs, have garnered attention not only in ancient healing traditions but also within modern health‐care systems. Their rich history is marked by a diverse array of therapeutic properties that have made them indispensable tools for promoting health and well‐being. Additionally, the utilization of EOs as food preservatives is an innovative and natural approach in extending the shelf life of various food products. In addition, EOs are beneficial in the treatment of cancer and other diseases. Because of their outstanding biological activities and health benefits, research on EOs has exploded in recent years. In present work, an intensive review was done on published data on therapeutic potential of some major EOs and their utilization as a preservative in food industries. Meanwhile, an investigation of the methods specifically used for the separation of EOs and regulatory considerations are also reported. The article concludes with comments on future trends.

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Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat

Cited by 34 publications

References 62 publications

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta

Voltage-operated potassium (Kv) channels contribute to endothelium-dependent vasorelaxation of carvacrol on rat aorta

Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze DriedSyzygium jambolanum(Lam.) DC Fruit Juice

A descriptive review on exploiting the therapeutic significance of essential oils as a potential nutraceutical and food preservative

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