Participation of the components of L-arginine/nitric oxide/cGMP cascade by chemically-induced abdominal constriction in the mouse

In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

“…It has been postulated that MB induces antinociceptive effect by inhibiting peripheral sGC and NO. As pre-treatment with MB and subsequent administration of MEDR at all doses increased antinociceptive activity in acetic acid induced writhing model in mice than the groups where only MEDR were administered, it is quite clear that the antinociceptive action of MEDR involves the NO-cGMP pathway (Abacioglu et al, 2000;Xu et al, 1995). Our present study also demonstrated that glibenclamide, an ATP-sensitive K+ channel antagonist, partly reversed the antinociceptive activity shown by MEDR.…”

“…Physiological functions such as analgesia are greatly influenced by the cellular level of cGMP maintained by the action of soluble guanylylcyclase (sGC) mediated by nitric oxide (NO) (Abacioglu et al, 2000). It has been described that the function of cGMP on the ion channel depends on the activation of protein kinases and phosphodiesterases (Xu et al, 1995).…”

“…Then the nociceptive responses against 0.6% acetic acid injection were observed for 30 min, starting from 5 min post injection. The numbers of abdominal writhing were counted as indication of pain behaviour (Abacioglu et al, 2000;Perimal et al, 2011).…”

Evaluation of antinociceptive and antiinflammatory activities of the essential oil (EO) of Ocimum micranthum Willd. from Northeastern Brazil

“…The precise mechanism of action of the antinociceptive effect of L-NAME within the central system is not clear. However, several experimental observations suggest L-NAME acts at a spinal level (Abacioglu et al, 2000). In this paper, L-NAME produced a significant decrease of the nociception in the first and second phase.…”

“…Inhibitors of NOS have been shown to exert antinociceptive effects in animal models (Okuda et al, 2001;Lázaro-Ibanez et al, 2001;Ortiz et al, 2003), but elucidation of the role of NO in peripheral and spinal events in nociception is complex. These contradictory results may depend on the animal studied and the painful stimulus used (Abacioglu et al, 2000). The inhibitor of NOS, L-NAME, exhibits potent antinociceptive activity in mice and rats (Okuda et al, 2001).…”