Participation of signaling proteins in sperm hyperactivation

Cordero-Martínez, Joaquín; Jiménez-Gutiérrez, Guadalupe Elizabeth; Aguirre-Alvarado, Charmina; Alcántara-Farfán, Verónica; Chamorro-Cevallos, Germán; Roa-Espitia, Ana Lilia; Hernández‐González, Enrique O.; Rodrı́guez-Páez, Lorena

doi:10.1080/19396368.2022.2122761

Cited by 2 publications

(1 citation statement)

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“…Redox signalling occurs alongside modification of thiol groups of proteins of the plasma membrane and the inner sperm compartments [53]. As a part of the capacitation process, the hyperactivated motility triggered by calcium signalling [59] is characterised by a high amplitude and extremely asymmetrical beating pattern of sperm flagellum, as well as lateral head displacement. These motility modifications are dependent on ROS-mediated tyrosine phosphorylation of flagellar protein and are needed to make spermatozoa that can penetrate the cumulus oophorous and zona pellucida and fertilise the oocyte [60,61].…”

Section: Ros and Sperm Physiologymentioning

confidence: 99%

Human Sperm as an In Vitro Model to Assess the Efficacy of Antioxidant Supplements during Sperm Handling: A Narrative Review

Moretti,

Signorini,

Corsaro

et al. 2023

Antioxidants

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Spermatozoa are highly differentiated cells that produce reactive oxygen species (ROS) due to aerobic metabolism. Below a certain threshold, ROS are important in signal transduction pathways and cellular physiological processes, whereas ROS overproduction damages spermatozoa. Sperm manipulation and preparation protocols during assisted reproductive procedures—for example, cryopreservation—can result in excessive ROS production, exposing these cells to oxidative damage. Thus, antioxidants are a relevant topic in sperm quality. This narrative review focuses on human spermatozoa as an in vitro model to study which antioxidants can be used to supplement media. The review comprises a brief presentation of the human sperm structure, a general overview of the main items of reduction–oxidation homeostasis and the ambivalent relationship between spermatozoa and ROS. The main body of the paper deals with studies in which human sperm have been used as an in vitro model to test antioxidant compounds, including natural extracts. The presence and the synergic effects of different antioxidant molecules could potentially lead to more effective products in vitro and, in the future, in vivo.

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