Participation of Neurochemical Signaling in Adult Neurogenesis and Differentiation

Пущина, Е. В.; Вараксин, А. А.; Обухов, Д. К.

doi:10.5772/58306

Cited by 4 publications

(5 citation statements)

References 57 publications

(49 reference statements)

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“…Signaling mechanisms, including receptors, sources of release and molecule transporters were installed for some neurotransmitters [31,32]. Our results suggest that TH and NO may act as signaling molecules that regulate processes of adult neurogenesis in the diencephalon and other regions of brain of O. masou [28]. In diencephalon, tectum, medulla oblongata and spinal cord of three-, sixmonth and one-year-old juvenile of masu salmon in the periventricular cells synthesis of TH is defined [19,27].…”

Section: Discussionmentioning

confidence: 73%

“…Study has shown that O. masou brain in different age periods contains proliferative zones (PZ) [28]. Cells expressing TH and NADPH-d/NOS were identified in PZ of diencephalon and medulla oblongata.…”

Section: Discussionmentioning

confidence: 99%

“…At the level of forebrain the distribution of TH-ip cells corresponds to neuromeric structure of brain, which is confirmed by PCNA labeling of matrix zones. On the border between the dorsal prosomeres P2-P3 the immunolabeling of TH and PCNA is absent [27,28]. In the diencephalon, localization of proliferative PCNA-ip regions correspond to prosomeric design of forebrain.…”

Section: Discussionmentioning

confidence: 99%

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Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Пущина¹

2015

AJBIO

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Localization of TH-and NO-producing systems in the diencephalon of juvenile masu salmon Oncorhynchus masou was investigated by using histofluorescence labeling of glyoxylic acid (GA), and ICH labeling of tyrosine hydroxylase (TH) and neuronal nitric oxide synthase (nNOS). High density distribution of catecholaminergic and NO-ergic cells has been found in preoptic, posterior tuberal and hypothalamic areas. Cells revealed in above mentioned diencephalic areas were assigned to three main types: pear-shaped, bipolar and rounded. Most of the TH-and NO-producing cells had the phenotype of undifferentiated elements localized on territory of diencephalic matrix zones. Paracrine and autocrine relationships between TH-and NO-producing cells in periventricular diencephalon of juvenile O. masou before formation of blood-brain barrier have been hypothesized. The lack of differentiated cells and the presence of a large variety of size groups of cells indicate a possible heterochrony in growth and differentiation of O. masou diencephalic areas. Location of catecholaminergic and NO-producing cells in the territory of diencephalic matrix zones suggests that catecholamines and nitric oxide are involved in the regulation of post-embryonic neurogenesis in diencephalon of O. masou.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Пущина¹

2015

AJBIO

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“…One of the proposed mechanisms of successful regeneration of nervous tissue of fish brain is an early response of microglia that determines the efficiency of elimination of damaged cells by apoptosis [1]. Being a convenient model for neurogenic study the animals from evolutionarily ancient groups are increasingly being used; in their brain are a large number of periventricular neurogenic zones and active zones of secondary neurogenesis [1,2]. After a damaging effect, processes of regeneration in the brain of fish is determined by several factors, differ from other vertebrates, including mammals and humans [3,4].…”

Section: Introductionmentioning

confidence: 99%

Multiphoton Confocal Microscopy (in vivo Imaging) in the Study of Early Response of Macrophages/Microglia in Damaged Midbrain of Juvenile Chum Salmon Oncorhynchus keta

Пущина¹

2015

AJBIO

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Abstract:We used multiphoton confocal microscopy for the in vivo study of early response of macrophages/microglia in the damaged midbrain of juvenile chum salmon Oncorhynchus keta. The results obtained allow the use of injection of DiI in the area of brain injury as a method to identify a population of phagocytic cells in the brain, based on the physiological response of macrophages/microglia. Thus, the injury with injection of small particles of dye DiI causes the phagocytic response from macrophages within a 30 minutes after the application of the damaging effects. This allows the use of DiI as a vital nonspecific marker of macrophages/microglia. It can be regarded as an effective method of identifying populations of phagocytic cells in the brain, as the effective molecular markers that allow selective identification of populations of macrophages and microglia in the brain of the fish have not been developed so far. We supposed that using multiphoton confocal microscopy in vivo experiments allow to have the substantial preference. Damage to living cells decreases photo induced processes, because of the much lower absorption of tissues and cells in the infrared region as compared with the ultraviolet one. For this reason, it provides more depth of penetration in biological objects (animal). The main beneficial consequence of this is the better survival of a biological object with good image quality.

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“…The evolutionarily ancient animal groups are often used as a convenient model for neurogenic studies in adults. The brain of such animals has a large number of periventricular proliferative zones and active zones of secondary neurogenesis [2,3]. In contrast to the mammalian brain, numerous proliferative regions have been found in adult fish.…”

Section: Introductionmentioning

confidence: 99%

Adult and Reparative Neurogenesis in Fish Brain

Пущина¹,

Вараксин²,

Stukaneva³

et al. 2017

Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Deve

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The fish brain has a unique feature of vertebrates-it grows with the growth of body over a lifetime. In this regard, fishes are a convenient model for the study of embryonic and postembryonic development of the central nervous system and of the influence of different factors on these processes. Currently, the mechanisms of adult brain morphogenesis of fish, which retain larval stage for a long time, are poorly understood. This is particularly true for participation of radial glia during morphogenesis of the brain, as well as the presence and distribution of the proliferative zone in the adult fish brain. Another interesting and little known aspect is the posttraumatic ability of fish to form active neurogenic niches. Investigation of the structural organizations of neurogenic niches and special conditions of the extracellular environment, as well as the interactions between neighboring cells in a neurogenic niche, is interesting and relevant direction in the study of the neuronal stem cells biology. Injury of fish brain creates special conditions for the implementation of genetic programs aimed at strengthening the proliferation of progenitor cells, as well as the activation and proliferation activity in the neuronal stem cells.

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Participation of Neurochemical Signaling in Adult Neurogenesis and Differentiation

Cited by 4 publications

References 57 publications

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Undifferentiated Catecholaminergic and NO-Producing Cells of Forebrain Matrix Zones and Intercellular Relationships in Periventricular Diencephalon of Juvenile Oncorhynchus masou

Multiphoton Confocal Microscopy (in vivo Imaging) in the Study of Early Response of Macrophages/Microglia in Damaged Midbrain of Juvenile Chum Salmon Oncorhynchus keta

Adult and Reparative Neurogenesis in Fish Brain

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