Participation of endotoxin in root canal infections: A systematic review and meta-analysis

Martinho, Frederico Canato; Rabello, Diego Guilherme Dias de; Ferreira, Leonardo L. G.; Nascimento, Gustavo G.

doi:10.4103/ejd.ejd_84_17

Cited by 37 publications

(38 citation statements)

References 70 publications

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“…The range of sensitivity is 0.1–1 EU mL −1 for the Chromogenic LAL assay, and 0.01–100 EU mL −1 for the Turbidimetric LAL assay (Martinho et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…, Martinho et al . , ). This review aimed to obtain information about reduction in LPS by NaOCl, the most widely used endodontic irrigant, and CHX, a potential chemical auxiliary substance applied in root canal treatment (Siqueira et al .…”

Section: Discussionmentioning

confidence: 99%

“…, Martinho et al . ). LPS is one of the most important virulent factors involved in the development of periapical inflammation (Pitts et al .…”

Section: Introductionmentioning

confidence: 97%

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Endotoxin levels after chemomechanical preparation of root canals with sodium hypochlorite or chlorhexidine: a systematic review of clinical trials and meta‐analysis

et al. 2018

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“…The range of sensitivity is 0.1–1 EU mL −1 for the Chromogenic LAL assay, and 0.01–100 EU mL −1 for the Turbidimetric LAL assay (Martinho et al . ).…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Endotoxin levels after chemomechanical preparation of root canals with sodium hypochlorite or chlorhexidine: a systematic review of clinical trials and meta‐analysis

et al. 2018

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“…Therefore, tooth extraction is the final option for severe oral health problems which there is no chance for success in dental and periodontal treatments in BD. Finally, these mediators in local milieu could be responsible for systemic immune responses, an oral‐systemic connection, as oral environment is a reservoir of microorganisms and a source of continuous infection …”

Section: Discussionmentioning

confidence: 99%

Oral health is a mediator for disease severity in patients with Behçet’s disease: A multiple mediation analysis study

Yay

Çelik

Aksoy

et al. 2018

J of Oral Rehabilitation

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Summary Objectives The aim of the study was to examine whether oral health as an infection focus could mediate disease course in patients with Behçet's disease (BD). Methods In the study, oral health of 194 BD patients was examined at baseline and follow‐up periods. The reasons for last dental visits were recorded as tooth extraction or regular control visits/planned treatments at the end of follow‐up period. The Behçet's disease severity score was calculated with higher scores indicating a more severe course. Mediation analysis was carried out to assess the effects of oral health on disease severity score at follow‐up period in the study. Results Dental and periodontal indices were found to be higher at follow‐up visit compared to those of baseline (P < 0.05). Disease severity score was found to be higher in males (5.3 ± 2.4) compared to females (4.4 ±2.5) in the whole group (P = 0.005). Moreover, patients having tooth extraction at their last dental visit and patients with dental caries had a more severe disease course (5.4 ± 2.4; 5.5 ± 2.5) compared to others (4.2 ± 2.3; 4.4 ± 2.4; P < 0.0001). In multiple mediation analysis, disease severity score was a dependent variable and was directly mediated by male gender (B = −0.8822, P = 0.0145) and indirectly mediated through the presence of dental caries (B = 0.9509 P = 0.0110) and need of tooth extraction (B = 0.8758, P = 0.0128). Conclusion Both presence of dental caries and need of tooth extraction were observed to be effective mediators for a more severe disease course in BD. Therefore, better oral health should be aimed to eliminate microbial factors, which are a part of pathogenic processes.

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“…Além disso, componentes estruturais bacterianos, incluindo peptidoglicano, parede celular, ácido lipoteicóico, fímbrias, flagelos, proteínas e vesículas da membrana externa, DNA, exopolissacarídeos e lipopolissacarídeos, são derramados nos tecidos perirradiculares e agem como irritantes estimulando o desenvolvimento de reações inflamatórias e de defesa imunológica que são capazes não só de defender o hospedeiro contra a infecção mas também de causar grave destruição tecidual (Henderson et al, 1996;Leonardo, 2004;van Amersfoort et al, 2003, Martinho et al, 2017.…”

Section: A Polpa Dentáriaunclassified

Avaliação da eficácia anestésica da Mepivacaína na exodontia de molares inferiores com lesão apical

Carrocini¹

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Esse ensaio clínico cego, de braços paralelos teve como objetivo avaliar a eficácia da Mepivacaína 2% com noradrenalina 1:100.000, no bloqueio do nervo alveolar inferior, em exodontias simples de molares inferiores com e sem lesão apical. Para isso, oitenta (80) participantes, pacientes do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo, com necessidade de exodontia de molares inferiores, foram incluídos em 2 grupos: um com 40 pacientes, que apresentavam dentes molares inferiores com lesão apical e outro sem lesão apical (40), confirmada radiograficamente. Na anamnese, pela Escala Verbal de Dor (EVD) (escore 0 a 3), quantificou-se presença de dor e medicação consumida. Foi utilizado 1,8 mL de Mepivacaína 2% associada à norepinefrina 1:100.000 para bloqueio do nervo alveolar inferior (BNAI), pela técnica pterigomandibular indireta das três posições. O sinal subjetivo de anestesia do lábio e língua, anestesia pulpar e ausência de dor durante o procedimento de exodontia, foram avaliados, respectivamente, por indagação ao paciente, pelo testador elétrico pulpar (TEP) e pela EVD. A anestesia pulpar (AP) foi checada pelo TEP, por duas leituras negativas ao estímulo máximo (80μA) do aparelho. Confirmada a anestesia pulpar, iniciava-se a exodontia. O sucesso do BNAI foi definido como a capacidade de finalizar o procedimento cirúrgico, sem relato de dor (escore 0 ou 1) pelo paciente, enquanto o insucesso foi caracterizado pelo incomodo/dor (escore 2 ou 3) durante a cirurgia, que impedisse a continuação da exodontia. Nesse caso, um segundo tubete foi aplicado por técnica complementar infiltrativa para finalização do procedimento. Na análise estatística utilizou-se o teste QuiQuadrado e Mann-Whitney com nível de significância fixado em 5%. No grupo de dentes sem lesão, a taxa de sucesso anestésico (exodontia) foi de 90% (36*/40) enquanto no grupo com lesão foi de 35% (14*/40). O BNAI foi eficiente para exodontia simples de dentes sem lesão apical, porém insuficiente para os com lesão apical, sendo necessária a complementação anestésica, por infiltração local. A efetividade do bloqueio anestésico parece ser alterada quando há lesão apical (processo inflamatório).

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Participation of endotoxin in root canal infections: A systematic review and meta-analysis

Cited by 37 publications

References 70 publications

Endotoxin levels after chemomechanical preparation of root canals with sodium hypochlorite or chlorhexidine: a systematic review of clinical trials and meta‐analysis

Endotoxin levels after chemomechanical preparation of root canals with sodium hypochlorite or chlorhexidine: a systematic review of clinical trials and meta‐analysis

Oral health is a mediator for disease severity in patients with Behçet’s disease: A multiple mediation analysis study

Avaliação da eficácia anestésica da Mepivacaína na exodontia de molares inferiores com lesão apical

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