Participation of dopamine in regulation of respiration

Колесникова, Е. Э.; Serebrovskaya, Tatiana V.

doi:10.1007/bf02463113

Cited by 5 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(9,10). Over the last few years, numerous studies have highlighted the role of DA in many physiological functions such as ventilation and neurological modulation of sleep(34)(35)(36)(37). In particular, during the arousal phase from sleep to wakefulness there is an increase in the firing activity of dopaminergic neurons of the SNpc.…”

mentioning

confidence: 99%

Neurobiological Alterations Of The Substantia Nigra In Sudden Infant Death Syndrome

Lavezzi¹,

Mehboob²,

Alfonsi³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background - The purpose of this study was to research possible morphological and functional alterations of the substantia nigra in SIDS. Methods - Brainstems of 46 victims of sudden infant death, aged from 1 to 7 months, were investigated. Twenty-six of these cases were diagnosed as SIDS, due to the lack of any pathological finding, while the remaining 20 cases, in which the cause of death was determined at autopsy, served as controls. Maternal smoking was reported in 10% of controls and 77% of SIDS. Histopathological examination of the substantia nigra was done on midbrain 5-µm-thick sections stained with hematoxylin-eosin and Klüver-Barrera. Densitometry, immunohistochemistry and histochemistry were applied to highlight the neuronal concentration, the expression of tyrosine hydroxylase and neuromelanin, respectively. Results - Hypoplasia of the pars compacta of the substantia nigra was observed in SIDS but not in controls. Tyrosine hydroxylase expression in the substantia nigra was significantly higher in controls than in SIDS. Neuromelanin was observed as dark granules only in 4 infants of the control group but never in SIDS. A significant correlation was found between hypoplasia/low neuronal density, low tyrosine hydroxylase expression in the substantia nigra pars compacta and maternal smoking. Conclusion - The substantia nigra pars compacta, that is the main dopamine center in the brain, is involved in the control of many functions, including the sleep-arousal phase, and hence, its structural and/or functional alterations may explain the pathogenesis of SIDS, that often occurs during sleep. This study also indicates that maternal smoking can may have strongly influenced the SN altered development. Trial registration – not applicable for this study

show abstract

mentioning

confidence: 99%

Neurobiological Alterations Of The Substantia Nigra In Sudden Infant Death Syndrome

Lavezzi¹,

Mehboob²,

Alfonsi³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…; Brooks, 1997 ; Jankovic, 2008 ). Further studies have highlighted the role of DA in additional physiological functions such as ventilation and neurological modulation of sleep ( Kolesnikova and Serebrovskaya, 1998 ; Cabezas et al., 2003 ; Dzirasa et al., 2006 ; Lima et al., 2007 ). In particular, during the arousal phase from sleep to wakefulness, there is an increase in the firing activity of dopaminergic neurons of the SNpc ( Dzirasa et al., 2006 ; Lima et al., 2007 , 2009 ).…”

Section: Discussionmentioning

confidence: 99%

Substantia Nigra Abnormalities Provide New Insight on the Neural Mechanisms Underlying the Sleep-Arousal Phase Dysfunctions in Sudden Infant Death Syndrome

et al. 2020

View full text Add to dashboard Cite

The purpose of this study was to research possible developmental alterations of the substantia nigra (SN) in sudden infant death syndrome (SIDS), a syndrome frequently attributed to arousal failure from sleep. Brain stems of 46 victims of sudden infant death, aged from 1 to about 7 months (4 to 30 postnatal weeks), were investigated. Twenty-six of these cases were diagnosed as SIDS, due to the lack of any pathological finding, while the remaining 20 cases in which the cause of death was determined at autopsy served as controls. Maternal smoking was reported in 77% of SIDS and 10% of controls. Histopathological examination of the SN was done on 5-µm-thick sections of caudal midbrain stained with both hematoxylin-eosin and Klüver-Barrera. Densitometry, immunohistochemistry and histochemistry were applied to highlight the neuronal concentration, the tyrosine hydroxylase (TH) expression, and the presence of neuromelanin (NM) in this structure. Hypoplasia of the pars compacta portion of the SN was observed in 69% of SIDS but never in controls; TH expression was significantly higher in controls than in SIDS; and NM was observed only in 4 infants of the control group but not in SIDS. A significant correlation was found between SIDS, hypoplasia/low neuronal density, low TH expression in the pars compacta, and maternal smoking. Because the SN pars compacta, being the major dopamine brain center, controls many functions, including the sleep-arousal phase, its alterations, especially concurrently with smoking exposure, may contribute to explain the pathogenesis of SIDS that occur in the great part of cases at awakening from sleep.

show abstract

“…The Parkinson disease (PD) is a chronic, progressive neurodegenerative movement disorder. It results from the degeneration and loss of dopamine-producing nerve cells in the brain, mainly in the SN [51]. It is well accepted that PD is a multietiological disease.…”

Section: Biomolecular Investigation Of Human Substantia Nigra (Sn) Inmentioning

confidence: 99%

Challenges in Biology and Medicine with Synchrotron Infrared Light

2009

View full text Add to dashboard Cite

The brightness (or brilliance) of synchrotron radiation was exploited in infrared microspectrosocopy. Among application of this synchrotron-based microanalytical technique, biological and biomedical investigations, at the diffraction-limited spot size, are exhibit of an increasing interest among almost all the existing infrared beamline worldwide. This paper is presenting the main properties of such a source, coupled with an infrared microscope. Several important applications in biomedical field are reported: cancer cells studies and drug effects, human substantia nigra in Parkinson's disease, β-amyloids deposits in Alzheimer's disease.

show abstract

Participation of dopamine in regulation of respiration

Cited by 5 publications

References 50 publications

Neurobiological Alterations Of The Substantia Nigra In Sudden Infant Death Syndrome

Neurobiological Alterations Of The Substantia Nigra In Sudden Infant Death Syndrome

Substantia Nigra Abnormalities Provide New Insight on the Neural Mechanisms Underlying the Sleep-Arousal Phase Dysfunctions in Sudden Infant Death Syndrome

Challenges in Biology and Medicine with Synchrotron Infrared Light

Contact Info

Product

Resources

About