Participation in Competing Strategies for Colorectal Cancer Screening: A Randomized Health Services Study (PICCOLINO Study)

Evaluating tests for diagnosing COVID-19 in the absence of a reliable reference standard: pitfalls and potential solutions

“…Here, we could assess outcomes such as participation, usability, positivity rate, and diagnostic yield, as done, for example, in colorectal cancer screening trials. [38] , [39] , [40] A drawback is that clinical effectiveness studies (including randomized trials) of medical tests are generally much more time- and resource-consuming than cross-sectional test accuracy studies, although this may be less of a problem in a pandemic setting due to the large number of potential study subjects and available funds.…”

Fecal immunochemical test (FIT) versus colonoscopy: Does knowing that a positive FIT requires a follow-up colonoscopy affect initial decision making in the US?

“…To increase screening uptake, providers should provide patients with multiple options for CRC screening. This is supported by randomized controlled trial data that found that offering patients a choice between colonoscopy or FIT (26.5%) improves screening uptake when compared to only recommending colonoscopy (17.5%; p < 0.001) ( Pilonis et al, 2021 ). However, studies investigating CRC screening discussion patterns found that providers only discuss multiple options with patients up to half the time ( Zapka et al, 2011 , Wolf et al, 2007 , Laiyemo et al, 2014 , Lafata et al, 2011 ).…”

Colorectal cancer screening with fecal immunochemical testing or primary colonoscopy: An analysis of health equity based on a randomised trial

“…Such comparability of the groups allocated to FIT × 2 and once-only PCOL strategies, may not be guaranteed in other RCTs that allow for a choice between FIT and PCOL within a screening arm. There are two other ongoing RCTs 11 , 12 which have been designed with separate FIT and PCOL arms, whereas another RCT 13 allowed for crossover between the PCOL and FIT arms and two other RCTs 14 , 15 have been designed to compare hybrid PCOL+FIT strategies against either PCOL or FIT as the control arm.…”