Participant characteristics of existing exercise studies in persons with multiple sclerosis – A systematic review identifying literature gaps

Gaemelke, Tobias; Frandsen, Jens Jakob; Hvid, Lars G.; Dalgas, Ulrik

doi:10.1016/j.msard.2022.104198

Multiple Sclerosis and Related Disorders

2022

DOI: 10.1016/j.msard.2022.104198

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Participant characteristics of existing exercise studies in persons with multiple sclerosis – A systematic review identifying literature gaps

Tobias Gaemelke¹,

Jens Jakob Frandsen²,

Lars G. Hvid³

et al.

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Cited by 3 publications

References 207 publications

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Physical fitness moderates the association between brain network impairment and both motor function and cognition in progressive multiple sclerosis

Tilsley,

Strohmeyer,

Heinrich

et al. 2023

J Neurol

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Physical fitness moderates the association between brain network impairment and both motor function and cognition in progressive multiple sclerosis

Tilsley,

Strohmeyer,

Heinrich

et al. 2023

J Neurol

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Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial—the MS BOOSTER trial

Taul-Madsen,

Hvid,

Sellebjerg

et al. 2024

BMJ Open

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IntroductionMultiple sclerosis (MS) causes a broad range of symptoms, with physical function being one of the most disabling consequences according to patients themselves. Exercise effectively improves lower extremity physical function. Nonetheless, it is unknown which exercise modality is most effective and it remains challenging to keep persons with MS adhering to exercise over a longer period. Therefore, the present study aims to investigate how exercise booster sessions (EBS) influence the sustainability of exercise-induced effects on physical function, and furthermore, to investigate which exercise modality (aerobic training or resistance training) is most effective in terms of improving physical function.Materials and methodsThis study is a multi-arm, parallel-group, open-label multicentre randomised controlled trial investigating the effects of EBS. Participants (n=150) are initially randomised to 12 weeks of either resistance training+usual care, aerobic training+usual care or usual care. After 12 weeks of intervention, participants in the exercise groups will again be randomised to either EBS+usual care or usual care during a 40-week follow-up period. The primary outcome is physical function (composite score based on 6-min walk test and five-time sit to stand), and the secondary outcomes are fatigue, cognition, physical activity, symptoms of depression and quality of life.Ethics and disseminationThe study is approved by the Central Denmark Region Committees on Health Research Ethics (1-10-72-237-21) and is registered at the Danish Data Protection Agency (2016-051-000001) and at Clinicaltrials.gov (NCT04913012). All study findings will be published in scientific peer-reviewed journals and presented at scientific conferences.Trial registration numberNCT04913012.

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Exercise as medicine in Parkinson’s disease

Langeskov-Christensen,

Franzén,

Grøndahl Hvid

et al. 2024

J Neurol Neurosurg Psychiatry

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Parkinson’s disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while pharmacological symptomatic treatments have limited effects in certain domains and cause side effects. Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal. Exercise is safe and represents a cornerstone in PD rehabilitation, but exercise may have even more fundamental benefits that could change clinical practice. In PD, the existing knowledge base supports exercise as (1) a protective lifestyle factor preventing the disease (ie, primary prevention), (2) a potential disease-modifying therapy (ie, secondary prevention) and (3) an effective symptomatic treatment (ie, tertiary prevention). Based on current evidence, a paradigm shift is proposed, stating that exercise should be individually prescribed as medicine to persons with PD at an early disease stage, alongside conventional medical treatment.

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Participant characteristics of existing exercise studies in persons with multiple sclerosis – A systematic review identifying literature gaps

Cited by 3 publications

References 207 publications

Physical fitness moderates the association between brain network impairment and both motor function and cognition in progressive multiple sclerosis

Physical fitness moderates the association between brain network impairment and both motor function and cognition in progressive multiple sclerosis

Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial—the MS BOOSTER trial

Exercise as medicine in Parkinson’s disease

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