Partial volume effects in dynamic contrast magnetic resonance renal studies

Gutierrez, Daniel Rodriguez; Wells, Kevin; Díaz, Oliver; Santana, Ángel Rodríguez; Mendichovszky, Iosif; Gordon, Isky

doi:10.1016/j.ejrad.2009.04.073

Cited by 12 publications

(12 citation statements)

References 15 publications

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“…The relationship between renal blood and plasma flow is not straightforwardly given by the large vessel haematocrit (as implied in text books [46]), and CT measurements would be equally affected. The higher values in the left-sided kidneys are probably an artefact, for which a possible explanation is poor slice profile [47].…”

Section: Shortcomings Of Dce-mri Measurementsmentioning

confidence: 99%

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

et al. 2012

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Section: Shortcomings Of Dce-mri Measurementsmentioning

confidence: 99%

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

et al. 2012

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“…The Patlak-Rutland plot method must take into account the input function estimated from heart and lung ROI measurements at RS (7) and from an ROI in the abdominal aorta at DCE MR urography (22,28). Other functional criteria at DCE MR urography have been published (1,5,11,(14)(15)(16), such as the slope of the uptake curve, the volume of contrast-enhancing renal parenchyma, the transit time between the cortex and the upper ureter and the 2-3-minute ratio of uptake as functional parameters.…”

Section: Discussionmentioning

confidence: 99%

“…(a) With RS, a poorer reproducibility score has been shown in patients younger than 6 months old or with a low glomerular filtration rate when 99m Tc mertiatide is used (23), and ROI drawing has been reported to be difficult in the presence of a very dilated renal pelvis, at least when dimercaptosuccinic acid is used (8). (b) With DCE MR urography, because functional information is obtained from a section of the kidney, sampling in a very thin parenchymal ROI may create a partial volume effect and generate errors in the SRF measurements (28). In severely dilated kidneys, placing an ROI or setting a key point by using the AUC and Patlak-Rutland method may be difficult, as illustrated in Figure 3 and observed in the expert review of the studies, in which a difference of at least two classes between RS and DCE MR urography was shown.…”

Section: 1)mentioning

confidence: 99%

Chronic Urinary Obstruction: Evaluation of Dynamic Contrast-enhanced MR Urography for Measurement of Split Renal Function

Claudon¹,

Durand²,

Grenier³

et al. 2014

Radiology

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).q RSNA, 2014 Purpose:To evaluate if measurement of split renal function (SRF) with dynamic contrast material-enhanced (DCE) magnetic resonance (MR) urography is equivalent to that with renal scintigraphy (RS) in patients suspected of having chronic urinary obstruction. Materials and Methods:The study protocol was approved by the institutional ethics committee of the coordinating center on behalf of all participating centers. Informed consent was obtained from all adult patients or both parents of children. This prospective, comparative study included 369 pediatric and adult patients from 14 university hospitals who were suspected of having chronic or intermittent urinary obstruction, and data from 295 patients with complete data were used for analysis. SRF was measured by using the area under the curve and the Patlak-Rutland methods, including successive review by a senior and an expert reviewer and measurement of intra-and interobserver agreement for each technique. An equivalence test for mean SRF was conducted with an a of 5%. Results:Reproducibility was substantial to almost perfect for both methods. Equivalence of DCE MR urography and RS for measurement of SRF was shown in patients with moderately dilated kidneys (P , .001 with the Patlak-Rutland method). However, in severely dilated kidneys, the mean SRF measurement was underestimated by 4% when DCE MR urography was used compared with that when RS was used. Age and type of MR imaging device had no significant effect. Conclusion:For moderately dilated kidneys, equivalence of DCE MR urography to RS was shown, with a standard deviation of approximately 12% between the techniques, making substitution of DCE MR urography for RS acceptable. For severely dilated kidneys, a mean underestimation of SRF of 4% should be expected with DCE MR urography, making substitution questionable.q RSNA, 2014

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“…It should also be noted that no additional corrections were applied to ensure that the lumen signal was devoid of partial volume or flow effect (Yankeelov et al, 2005;Gutierreza et al, 2010) in this study. The larger scatter for analysis with measured AIF, as represented by the 95% limits of agreement in the Bland-Altman plots, might be explained by uncertainty in signal conversion among individual studies.…”

Section: Discussionmentioning

confidence: 99%

A comparison of dynamic contrast‐enhanced CT and MR imaging‐derived measurements in patients with cervical cancer

Kim

Haider

Milosevic

et al. 2012

Clin Physio Funct Imaging

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This work is to compare the kinetic parameters derived from the DCE-CT and -MR data of a group of 37 patients with cervical cancer. The modified Tofts model and the reference tissue method were applied to estimate kinetic parameters. In the MR kinetic analyses using the modified Tofts model for each patient data set, both the arterial input function (AIF) measured from DCE-MR images and a population-averaged AIF from the literature were applied to the analyses, while the measured AIF was used for the CT kinetic analysis. The kinetic parameters obtained from both modalities were compared. Significant moderate correlations were found in modified Tofts parameters [volume transfer constant(K(trans) ) and rate constant (k(ep) )] between CT and MR analysis for MR with the measured AIFs (R = 0·45, P<0·01 and R = 0·40, P<0·01 in high-K(trans) region; R = 0·38, P<0·01 and R = 0·80, P<0·01 in low-K(trans) region) as well as with the population-averaged AIF (R = 0·59, P<0·01 and R = 0·62, P<0·01 in high-K(trans) region; R = 0·50, P<0·01 and R = 0·63, P<0·01 in low-K(trans) region), respectively. In addition, from the Bland-Altman plot analysis, it was found that the systematic biases (the mean difference) between the modalities were drastically reduced in magnitude by adopting the population-averaged AIF for the MR analysis instead of the measured ones (from 51·5% to 18·9% for K(trans) and from 21·7% to 4·1% for k(ep) in high-K(trans) region; from 73·0% to 29·4% for K(trans) and from 63·4% to 24·5% for k(ep) in low-K(trans) region). The preliminary results showed the feasibility in the interchangeable use of the two imaging modalities in assessing cervical cancers.

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Partial volume effects in dynamic contrast magnetic resonance renal studies

Cited by 12 publications

References 15 publications

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

Precise measurement of renal filtration and vascular parameters using a two-compartment model for dynamic contrast-enhanced MRI of the kidney gives realistic normal values

Chronic Urinary Obstruction: Evaluation of Dynamic Contrast-enhanced MR Urography for Measurement of Split Renal Function

A comparison of dynamic contrast‐enhanced CT and MR imaging‐derived measurements in patients with cervical cancer

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