Partial Trisomy Chromosome 5 Cosegregating With Schizophrenia

Abstract

SummarySchizophrenia was associated with a distinct autosomal abnormality in two related mildly dysmorphic individuals. The finding of cosegregation of schizophrenia and a partial trisomy of chromosome 5 in the family suggests a potential location of a gene or genes linked to schizophrenia.

Alcoholic Hallucinosis: a psychiatric enigma–2. Follow‐up Studies

“…At the present time considerable developments in this field with implications for general medicine and psychiatry are taking place (Baron et al, 1987;Bassett et al, 1988;Egeland et al, 1987;Gurling, 1985). These have consequences not only for a greater understanding of aetiological factors, but also for treatment and prevention.…”

Familial 5q11.2→q13.3 segmental duplication cosegregating with multiple anomalies, including schizophrenia

“…At that time he was noted to have an unusual appearance and a family history of schizophrenia [Bassett et al, 1988].…”

“…The particular characteristics of schizophrenia and renal anomalies suggest that single major genes associated with these phenotypes may lie within this aneuploid region. A preliminary report of this family has been published [Bassett et al, 1988].…”

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia

“…A report by Bassett et al (1988) describes the coin-heritance of a chromosomal triplication, 5q11.2-5q13.3, with schizophrenia in a well-characterized Canadian family of Chinese descent. The two affected members of this family, a 20-year-old man and his 53-year-old uncle, share a phenotype of neuroleptic responsive schizophrenia with typical psychotic and deficit symptoms.…”

“…"Schizophrenialinked" DNA markers p105-153Ra (D5S39) and p105-599Ha (D5S76) map within the trisomy and proximal to the 5q11.2 breakpoint, respectively. The hybrid cell lines HHW 105 and HHW 1064 together provide a means to identify and generate syntenic DNA markers to further investigate the location of a schizophrenia locus.A report by Bassett et al (1988) describes the coin-heritance of a chromosomal triplication, 5q11.2-5q13.3, with schizophrenia in a well-characterized Canadian family of Chinese descent. The two affected members of this family, a 20-year-old man and his 53-year-old uncle, share a phenotype of neuroleptic responsive schizophrenia with typical psychotic and deficit symptoms.…”