Partial thyroid arterial embolization for the treatment of hyperthyroidism

Brzozowski, Krzysztof; Piasecki, Piotr; Zięcina, Piotr; Frankowska, Emilia; Jaroszuk, Andrzej; Kamiński, Grzegorz; Bogusławska-Walecka, Romana

doi:10.1016/j.ejrad.2011.03.071

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…No other serious complications occurred. These observations about the safety of the procedure were in accordance with those observed previously in our department and reported in the literature [2, 27–32, 36]. …”

Section: Discussionsupporting

confidence: 92%

“…For that reason, CT performed before and after the arterial embolization (at the end of the observation time) seems to be the most applicable imaging technique to assess and compare the thyroid volume values. Generally, the mean change in thyroid volume was highly statistically significant in the present study (51.58 ml—37 %) and the reduction in subjects with three obliterated arteries (78.8 ml—43.8 %) corresponded with the clinical observation of Xiao et al [2] Previously, CT examination performed 3 months after embolization visualized goiter volume reduction of approximately 32 % of its original volume (from 13.0 to 76.3 %) with mean thyroid volume of 94 ml [32]. Decrease in the size of goiter was accompanied with the compression symptoms improvement, especially in patients with a huge goiter.…”

Section: Discussionsupporting

confidence: 90%

“…In the previously published study by our team, we observed elevated values of fT4 and fT3 3 days after embolization, which showed quick reversal to near-normal or normal levels during follow-up [32]. Similarly, peak fT4 level was noted 3 days and fT3 level 7 days after embolization in present results, with a gradual normalization reached after 1 month.…”

Section: Discussionsupporting

confidence: 82%

“…Available data confirm usefulness of this method in patients affected by toxic goiter, recurrent goiter, Graves’ disease (GD) or even thyroid carcinoma [2, 26–31]. The previous study conducted in our department supports these observations by showing that thyroid arterial embolization may be offered as an effective alternative for patients who will not or cannot accept standard therapy [32]. However, the influence of this procedure on calcium–phosphate balance and the autoimmune processes has not been fully evaluated to date.…”

Section: Introductionmentioning

confidence: 60%

“…However, only few medical centers provided data about the possible advantages of arterial embolization in endocrinology [2, 25, 26, 29–32, 34]. …”

Section: Discussionmentioning

confidence: 99%

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The calcium–phosphate balance, modulation of thyroid autoimmune processes and other adverse effects connected with thyroid arterial embolization

et al. 2013

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In search of new treatment options for thyroid diseases, when conventional procedures are ineffective, contraindicated or associated with serious side effects, safety of thyroid arteries embolization in the treatment of particular thyroid diseases was evaluated. The study included eight subjects with retrosternal toxic goiter, six patients affected by Graves’ disease, five cases of retrosternal non-toxic goiter, two subjects with post-amiodarone hyperthyroidism, and one patient with severe thyroid-related orbitopathy, who underwent selective embolization of thyroid arteries. The study assessed and compared calcium–phosphate balance, modulation of thyroid autoimmunity and the presence of different side effects in patients who underwent the procedure. In addition, the serum concentrations of thyroid hormones, anti-thyroid autoantibodies and thyroid volume have been measured. Five of all enrolled subjects (22.7 %) experienced transient, not clinically relevant hypocalcaemia with no need for calcium supplementation. There were no significant changes in serum calcium levels in patients after embolization of both inferior thyroid arteries. The transient side effects associated with the treatment were neck pain and a slight increase in body temperature. Noted high concentration of free thyroid hormones immediately after the procedure was not accompanied by worsening of symptoms or signs of thyrotoxicosis. In patients with Graves’ disease, a significant decrease in thyrotropin receptor antibodies level was observed. Thyroid arterial embolization does not disturb permanently calcium–phosphate balance, modulates positively thyroid autoimmune processes and is associated with no serious post-procedure side effects. Hence, it may be considered as a safe and effective treatment modality for selected thyroid disorders.

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