Partial Thromboplastin Time

Reddy, Neena M.; Hall, Stephen W.; MacKintosh, F. Roy

doi:10.1001/archinte.159.22.2706

Cited by 35 publications

(3 citation statements)

References 18 publications

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“…Shortened APTTs values are found with a prevalence of 2.5%–5% in hospitalized patients [8], [17]. In our study, whether patients were grouped according to HbA1c or FPG levels, the APTT values in the diabetic, high-risk diabetic or IFG groups were significantly shorter than in the normal groups, and APTT values below the reference range (APTT <22 s) were more frequent.…”

Section: Discussionmentioning

confidence: 39%

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Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values

Zhao

Zhang

et al. 2011

PLoS ONE

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ObjectiveThis study was designed to examine the relationship between shortened activated partial thromboplastin time (APTT) and increased fibrinogen values with diabetes mellitus.MethodsAPTT, prothrombin time (PT), fibrinogen, fasting plasma glucose (FPG) and glycosylated hemoglobin A1c (HbA1c) levels were measured in 1,300 patients. Patients were divided into three groups according to their HbA1c and FPG levels.ResultsWhen participants were grouped according to their HbA1c levels, we found significantly shorter APTT values (26.9±5.6 s) and increased fibrinogen levels (3.1, 1.9–6.3 g/L) in the diabetes group when compared with the other two groups. When participants were grouped according to their FPG levels, we found significantly shorter APTT values (26.9±6.2 s) and increased fibrinogen levels (3.1, 1.8–6.2 g/L) in the diabetes group when compared with the euglycemic group.ConclusionsShorter APTT and increased fibrinogen levels might be useful hemostatic markers in patients with diabetes and in patients at high risk for diabetes.

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Section: Discussionmentioning

confidence: 39%

“…Epidemiological studies have found a significant association between fibrinogen levels and insulin levels [7], [8]. Markers of fibrinolysis are abnormal in people with metabolic syndrome, and fibrinolytic dysfunction is markedly increased in subjects with diabetes mellitus and abdominal obesity [7], [9].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values

Zhao

Zhang

et al. 2011

PLoS ONE

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show abstract

“…Epidemiological studies have found a significant association between fibrinogen levels and insulin levels [8,9]. Markers of fibrinolysis are abnormal in people with metabolic syndrome and fibrinolytic dysfunction is markedly increased in subjects with diabetes mellitus and abdominal obesity [8,10].…”

Section: Introductionmentioning

confidence: 99%

Association of activated partial thromboplastin time and fibrinogen level in patients with type II diabetes mellitus

2013

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BackgroundPatients with diabetes mellitus have a high risk of atherothrombotic events. Diabetes contributes for initiation and progression of microvascular and macrovascular complications. Shortened activated partial thromboplastin time (aPTT) values may reflect hypercoaguable state, which is associated with increased thrombotic risk and adverse cardiovascular events. Increased level of fibrinogen is common in type II diabetes. The present study was conducted to study the aPTT and fibrinogen levels in diabetics in a tertiary care Teaching Hospital of Nepal.MethodsObservational study was performed at out-patients visiting Pathology Department at Tribhuvan University Teaching Hospital from August 5 to September 7, 2012. Research protocol was approved by Institutional Review Board at Tribhuvan University Institute of Medicine. Altogether 90 people who came to the hospital during study period and who met inclusion criteria were selected, out of which 72 were diabetics and 18 were normal controls. Diabetic cases were identified via verbal interview with patients themselves and review of laboratory findings and diagnosis performed by their physicians. Diabetics with a diabetic history of more than one year and stabilized with antidiabetic medicines such as insulin, metformin, glibenclamide, and gliclazide and diabetics with controlled diabetes as revealed by HbA1c in the range 6.2-7% were taken for the study purpose. Data were analyzed with chi square test and Fischer’s exact test (when each cell frequency was less than 5) using Statistical Package for Social Sciences 17.ResultsMaximum (53; 73.6%) diabetics and all non-diabetics had aPTT in the range 26–40 seconds. Maximum (51; 70.8%) patients had fibrinogen beyond 351 whereas all non-diabetics had fibrinogen in the range 151–350. Mean aPTT values of the diabetic patients and non-diabetic persons were 29.88 ± 4.89 seconds and 32.44 ± 2.25 seconds respectively. Mean fibrinogen values of the diabetic patients and non-diabetic persons were 388.57 ± 60.90 mg/dL and 320.89 ± 10.20 mg/dL respectively. Test data identified in results were statistically significant for aPTT (p value 0.000) and fibrinogen (p value 0.000) between the diabetics and non-diabetics.ConclusionsDiabetics have an increased level of fibrinogen and relatively shortened aPTT as compared to the non-diabetic patients.

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The clinical significance of a shortened activated partial thromboplastin time in patients with connective tissue disease

et al. 2021

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Partial Thromboplastin Time

Abstract: Abnormally fast PTTs, particularly if confirmed on repeated testing, indicate a significant risk of subsequent death, thrombosis, bleeding, and overall morbidity. Careful examination of patients with low PTTs may reduce such associated morbidity and mortality.

Cited by 35 publications

References 18 publications

Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values

Diabetes Mellitus Is Associated with Shortened Activated Partial Thromboplastin Time and Increased Fibrinogen Values

Association of activated partial thromboplastin time and fibrinogen level in patients with type II diabetes mellitus

The clinical significance of a shortened activated partial thromboplastin time in patients with connective tissue disease

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