Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells

Trachootham, Dunyaporn; Chingsuwanrote, Pimjai; Yoosadiang, Penkhair; Mekkriangkrai, Duangsamon; Ratchawong, Tanapat; Buraphacheep, Nicha; Kijanukul, Siripa; Saekhow, Sumrit; Pongpitchayadej, Orawan; Vongvachvasin, Kittituch; Sittikornpaiboon, Paknisa; Tuntipopipat, Siriporn

doi:10.1080/01635581.2017.1339097

Cited by 12 publications

(12 citation statements)

References 42 publications

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“…We revealed that suppression of Akt-c-Myc-HK2 axis played a critical role in Tan IIA-induced anti-tumor activity. Currently, a panel of natural products, including garcinol 40 , Salvianolic acid B 41 , and xylitol 42 , have been identified to suppress OSCC cells via inhibition of glycolysis. Moreover, attenuation of HK2-mediated glycolysis by small compounds impaired the malignant phenotypes of various human cancers, such as non-small cell lung cancer and colon cancer [43][44][45] .…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

Gao

Zhao

et al. 2020

Cell Death Dis

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Aerobic glycolysis is one of the hallmarks of human cancer cells. Overexpression of hexokinase 2 (HK2) plays a crucial role in the maintaining of unlimited tumor cell growth. In the present study, we found that the oral squamous cell carcinoma (OSCC) cells exhibited an aerobic glycolysis phenotype. Moreover, HK2 is highly expressed in OSCC patient derived-tissues and cell lines. Depletion of HK2 inhibited OSCC cell growth in vitro and in vivo. With a natural product screening, we identified Tanshinone IIA (Tan IIA) as a potential anti-tumor compound for OSCC through suppressing HK2-mediated glycolysis. Tan IIA decreased glucose consumption, lactate production, and promoted intrinsic apoptosis in OSCC cells. The mechanism study revealed that Tan IIA inhibited the Akt-c-Myc signaling and promoted E3 ligase FBW7-mediated c-Myc ubiquitination and degradation, which eventually reduced HK2 expression at the transcriptional level. In summary, these results indicate that targeting HK2-mediated aerobic glycolysis is a promising anti-tumor strategy for OSCC treatment.

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Section: Discussionmentioning

confidence: 99%

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

Gao

Zhao

et al. 2020

Cell Death Dis

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“…Studies have shown that xylitol inhibits cancer cells, including lung cancer. These results indicate that xylitol has potential for use in lung cancer therapy, acting by inhibiting cell proliferation [ 98 , 99 ].…”

Section: D-xylose/xylitol and Some Cancersmentioning

confidence: 99%

Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19

Cheudjeu¹

2020

Life Sciences

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The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, obesity, and hypertension. Inflammation of the lungs is the main factor leading to respiratory distress in patients with chronic respiratory disease and in patients with severe COVID-19. Several studies have shown that inflammation of the lungs in general and Type 2 diabetes are accompanied by the degradation of glycosaminoglycans (GAGs), especially heparan sulfate (HS). Several studies have also shown the importance of countering the degradation of HS in lung infections and Type 2 diabetes. D-xylose, which is the initiating element for different sulfate GAG chains (especially HS), has shown regeneration properties for GAGs. D-xylose and xylitol have demonstrated anti-inflammatory, antiglycemic, antiviral, and antibacterial properties in lung infections, alone or in combination with antibiotics. Considering the existing research on COVID-19 and related to D-xylose/xylitol, this review offers a perspective on why the association between D-xylose and antibiotics may contribute to significantly reducing the duration of treatment of COVID-19 patients and why some anti-inflammatory drugs may increase the severity of COVID-19. A strong correlation with scurvy, based on gender, age, ethnicity, smoking status, and obesity status, is also reviewed. Related to this, the effects of treatment with plants such as Artemisia are also addressed. Chemical compounds D-xylose; xylitol; l -ascorbic Acid; D-glucuronic acid; N -acetylglucosamine; D- N -acetylglucosamine; N -acetylgalactosamine; galactose.

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“…Research and chemical technology have provided synthetic intense sweeteners and special carbohydrates whose consumption has helped curb pathological developments. A recent study suggested that partial substitution of glucose with xylitol may selectively inhibit the proliferation of oral cancer cells [71]. A related anti-tumor effect was noted already 35 years ago in rats bearing hepatocellular carcinomas (referred to in [46]).…”

Section: Discussionmentioning

confidence: 95%

Sugar alcohols and prevention of oral diseases―comments and rectifications

Mäkinen¹

2017

Oral Health Care

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Substituting sugar (sucrose and related fermentable saccharides) with low-calorie carbohydrates and sugar alcohols constitutes a well-founded approach to controlling energy intake in the prevention of obesity and certain diseases, and to limiting the occurrence of bacteria-associated diseases such as dental caries. The present concise review discusses selected sugar-substitute applications of alditol-type sugar alcohols and disaccharide polyols. In the former category, erythritol (a tetritol) and xylitol (a pentitol) will receive special attention. Xylitol has been shown to exert interesting biochemical effects-such as formation of ammonia and basic amino acids-in dental biofilm (dental plaque). These nitrogen-associated metabolic features have remained unnoticed because data concerning them were published already in the 1970s in supplements to regular journal volumes. Thus, the present review highlights the oral biologic significance of the xylitol-associated shift observed in the biology of oral biofilm: from carbohydrate dominance to one where nitrogen metabolism plays an important role. This review also comments on the synergy between certain oral health adjuvants (e.g., chlorhexidine and fluoride) and alditols, and on the use of alditols in periodontal treatments (i.e., non-sweet applications of alditols), and provides insights to European Union regulations on sugar substitutes. The article also attempts to rectify defective information regarding these sweeteners, including that contained in a recent Cochrane Xylitol Review. A brief discussion on certain physicochemical aspects of alditols will be provided to facilitate an understanding of the oral biological processes involved.

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Partial Substitution of Glucose with Xylitol Suppressed the Glycolysis and Selectively Inhibited the Proliferation of Oral Cancer Cells

Cited by 12 publications

References 42 publications

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19

Sugar alcohols and prevention of oral diseases―comments and rectifications

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