Partial sequence data from three evolutionarily conserved loci from the proximal short arm of the human X chromosome; assignment of DXF34S1 to Xp11.21-cen

Reed, Vivienne; Laval, Steven H.; Maslen, G.; Boyd, Yvonne

doi:10.1159/000133460

Cytogenet Genome Res

1993

DOI: 10.1159/000133460

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Partial sequence data from three evolutionarily conserved loci from the proximal short arm of the human X chromosome; assignment of DXF34S1 to Xp11.21-cen

Vivienne Reed¹,

Steven H. Laval²,

G. Maslen³

et al.

Abstract: DNA sequence data have been obtained from three clones derived from the human X chromosome which contain evolutionarily conserved sequences. Primers have been designed which enable these loci to be defined as sequence-tagged-sites (STS’s). The assignment of one of the loci, DXF34S1, has been refined to Xp11.21-cen, thus limiting the novel pericentromeric segment of homology defined by this locus to the extreme proximal region of Xp.

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Partial inversion of gene order within a homologous segment on the X Chromosome

Laval

Boyd

1993

Mammalian Genome

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The locus for the erthyroid transcription factor, GATA1, has been positioned in the small interval between DXS255 and TIMP on the proximal short arm of the human X Chromosome (Chr) by use of a partial human cDNA clone and a well-characterized somatic cell hybrid panel. Analysis of selected recombinants from 108 Mus musculus x Mus spretus backcross progeny with the same clone confirmed that the homologous murine locus (Gf-1) lies between Otc and the centromere of the mouse X Chr. These data imply that a partial inversion of gene order has occurred within the conserved segment that represents Xp21.1-Xp11.23 in human (CYBB-GATA1) and the proximal 6 cM of the mouse X Chr (Gf-1-Timp). Furthermore, they indicate that the mouse mutant scurfy and the human genetic disorder Wiskott-Aldrich syndrome, which have been mapped to the same regions as GATA1/Gf-1 in both species, may indeed be homologous disorders.

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Partial inversion of gene order within a homologous segment on the X Chromosome

Laval

Boyd

1993

Mammalian Genome

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show abstract

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Partial sequence data from three evolutionarily conserved loci from the proximal short arm of the human X chromosome; assignment of DXF34S1 to Xp11.21-cen

Cited by 1 publication

References 1 publication

Partial inversion of gene order within a homologous segment on the X Chromosome

Partial inversion of gene order within a homologous segment on the X Chromosome

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