Partial Respiratory Motion Compensation for Abdominal Extracorporeal Boiling Histotripsy Treatments With a Robotic Arm

Thomas, Gilles P.; Khokhlova, Tatiana D.; Khokhlova, Vera A.

doi:10.1109/tuffc.2021.3075938

Cited by 15 publications

(8 citation statements)

References 46 publications

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“…The feasibility and safety of this system have been demonstrated through in vivo ablation experiments in the porcine liver ( 145 ) and in the porcine kidney ( 146 ). Fixing the boiling histotripsy transducer on a robotic arm with partial respiration motion compensation can reduce targeting errors caused by respiration motion ( 147 ). The ex vivo experiment ( 147 ) showed a reduction of at least 89% of the value of the targeting error during treatment, while the treatment time increased by no more than 1%.…”

Section: Optimization Of Histotripsy Systemsmentioning

confidence: 99%

“…Fixing the boiling histotripsy transducer on a robotic arm with partial respiration motion compensation can reduce targeting errors caused by respiration motion ( 147 ). The ex vivo experiment ( 147 ) showed a reduction of at least 89% of the value of the targeting error during treatment, while the treatment time increased by no more than 1%. This technique is helpful for the histotripsy ablation of treatment sites that are more affected by respiratory motion.…”

Section: Optimization Of Histotripsy Systemsmentioning

confidence: 99%

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Research progress and clinical evaluation of histotripsy: a narrative review

Li¹,

Wei²,

Zhang³

et al. 2023

Ann Transl Med

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Background and Objective: As a soft-tissue noninvasive ablation technology, high-intensity focused ultrasound (HIFU) has been widely used to treat many clinical diseases. However, traditional HIFU, based on thermal effects, has a high local working temperature, which may cause thermal damage to surrounding tissues and reduce the therapeutic effect. Based on the cavitation effect of HIFU, histotripsy can mechanically destroy the cells in the target lesion. This paper aims to explain the mechanism of histotripsy, summarize the research progress of animal models for clinical evaluation and clinical application, and analyze the advantages and limitations of histotripsy.Methods: Literature published from January 2006 to March 2022 was retrieved from the PubMed database.We reviewed these articles to examine histotripsy from the aspects of the mechanism, animal experiments, clinical trials, advantages, disadvantages, and optimization.

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Section: Optimization Of Histotripsy Systemsmentioning

confidence: 99%

Section: Optimization Of Histotripsy Systemsmentioning

confidence: 99%

Research progress and clinical evaluation of histotripsy: a narrative review

Li¹,

Wei²,

Zhang³

et al. 2023

Ann Transl Med

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“…Robotic‐assistance was introduced in many studies to improve the accuracy of ultrasonic targeting. 22 , 23 , 24 , 25 , 26 , 27 As an example, Kujawska et al. 25 , 26 developed a computer‐controlled robotic system with 4 DOF for FUS ablation preclinical studies.…”

Section: Introductionmentioning

confidence: 99%

“…Robotic-assistance was introduced in many studies to improve the accuracy of ultrasonic targeting. [22][23][24][25][26][27] As an example, Kujawska et al 25,26 developed a computer-controlled robotic system with 4 DOF for FUS ablation preclinical studies. The 4 DOF positioner is attached on a water-filled tank to maneuver a dedicated platform that carries the target relative to the FUS transducer, which is fixed coaxially with an ultrasound imaging probe on the bottom of the tank facing towards the underside of the target.…”

Section: Introductionmentioning

confidence: 99%

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Robotic device for transcranial focussed ultrasound applications in small animal models

Antoniou

Giannakou

Georgiou

et al. 2022

Robotics Computer Surgery

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Background Focussed Ultrasound (FUS) combined with microbubbles (MBs) was proven a promising modality for non‐invasive blood brain barrier disruption (BBBD). Herein, two devices for FUS‐mediated BBBD in rodents are presented. Methods A two‐axes robotic device was manufactured for navigating a single element FUS transducer of 1 MHz relative to the brain of rodents. A second more compact device featuring a single motorized vertical axis was also developed. Their performance was assessed in terms of motion accuracy, MRI compatibility and trans‐skull BBBD in wild type mice using MBs in synergy with pulsed FUS. Results Successful BBBD was evidenced by the Evans Blue dye method, as well as by Fibronectin and Fibrinogen immunostaining. BBB permeability was enhanced when the applied acoustic intensity was increased. Conclusions The proposed devices constitute a cost‐effective and ergonomic solution for FUS‐mediated BBBD in small animal models. Further experimentation is needed to examine the repeatability of results and optimise the therapeutic protocol.

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