Partial ptosis, dilated pupils and ataxia following abamectin poisoning

Abamectin: an uncommon but potentially fatal cause of pesticide poisoning

“…The toxic effects of avermectin in humans are not clearly defined. 1 It is a Chinese pesticide whose acute oral lethal dose is reported to be 10 mg / kg. Symptoms usually appear within 8 hours of exposure.…”

“…Toxic effects can be attributed to the GABAnergic effects of avermectins. 1 Higher concentrations lead to neuronal release of GABA, thereby causing the increase of the membrane permeability of Chloride ions, resulting in central nervous system inhibition and nerve muscle conduction delay. The central nervous system inhibition results in anxiety, irritability, drowsiness, mental depression, convulsions, ataxia, and even coma.…”

Perspective choosing your poison

“…Reported effects include fever, bone pain, pruritus, mydriasis, hypotension and tachycardia. In contrast to common organophosphate poisoning presented with cholinergic signs patients with abamectin poisoning present with dilated pupils, ataxia and confusion (4). The only available series describing patients with ingested abamectin observed nausea, vomiting, diarrhoea, drowsiness, agitation and weakness.…”

“…Aspiration pneumonia was associated with adverse outcome. (4). Abamectin stimulates gama amino butyric acid (GABA) receptors in the central nervous system.…”

Yoğun bakımda takip edilen bir abamektin intoksikasyonu olgusu

“…Abamektinin toksisitesinin oral alımla olduğu ancak nadiren temas yoluyla da etkisinin olabileceği bildirilmektedir. İntoksikasyon bulguları şunlardır; midriyazis, kusma, tremor, miyoklonus, polinöropati, ataksi, nöbet, parsiyel pitozis, konfüzyon ve koma [6][7][8] . Hafif zehirlenme bulguları arasında ise bulantı, kusma diyare ve halsizlik bulunmaktadır 5,9 .…”