Partial Protection of Mice by Human Gamma-Globulin Against Staphylococcus aureus on Subcutaneous Sutures.

Taubler, James H.; Mudd, Stuart; Sall, Theodore

doi:10.3181/00379727-109-27090

Cited by 3 publications

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“…The biological significance of human globulins causing S. aureus bacteriostasis is not clear, despite the demonstration of their efficacy in preventing experimental infection (27,31). Cybulska and Jeljaszewicz regard the phenomenon as a laboratory curiosity because of variation in animal species (5), whereas MacLeod and coworkers relate this variation to the variation in resistance of different animal species to S. aureus infection (20).…”

Section: Discussionmentioning

confidence: 99%

“…The effect is generally attributed to bactericidins (19), lysozyme (17), C-reactive protein (22), iron-binding protein (24), substances released from white blood cells during clotting (15), or progesterone (32), or a combination of these. Although human globulins are known to be active inhibitors of S. aureus growth (9,11,27), this action is generally not attributed to antibody because of lack of specificity, reversal of inhibitory action by coagulase, and failure to utilize complement (9,11,18). The biological significance of serum bacteriostasis is obscure.…”

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confidence: 99%

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Serum Bacteriostasis of Staphylococcus aureus

1971

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Serum bacteriostasis of Staphylococcus aureus was characterized quantitatively and qualitatively. Bacteriostasis was proportional to the concentration of serum. Reproducibility was good; freezing and thawing did not materially affect the end point. Four of six different strains, including the propagating S. aureus strain for phage 73 which does not produce coagulase, were susceptible to serum bacteriostasis in similar titers; two were not susceptible at all. All six strains were effective inhibitors of bacteriostasis. Active and inactive coagulase were also inhibitors. In contrast to sensitive S. aureus, S. epidermidis and Streptococcus salivarius were not uniformly susceptible to bacteriostasis by different serums. Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Salmonella montevideo, S. zymogenes, and Diplococcus pneumoniae were not susceptible. Among gram-positive bacteria, only D. pneumoniae inhibited S. aureus bacteriostasis. Agglutinins of S. aureus and nonspecific substances such as lysozyme, 3-lysin, C-reactive protein, and transferrin were not responsible for S. aureus serum bacteriostasis. After diethylaminoethyl column fractionation of serum, the bacteriostatic principle was eluted in proximity to blood group antibody; immunoglobulins A, G, and M appeared to be present in bacteriostatic fractions. It is suggested that S. aureus bacteriostasis by serum is due to natural antibody and that inhibitory reactions with pneumococci and coagulase are due to common antigens.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Serum Bacteriostasis of Staphylococcus aureus

1971

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“…1. These data include the control mice infected with strain 18Z as previously published (Taubler et al, 1962) and those data given in Table 1. The numbers, plotted on a logarithmic scale, of organisms initially present on the subcutaneously placed portion of infectious sutures and the percentages of mice developing purulent lesions are related linearly.…”

Section: Resultsmentioning

confidence: 99%

“…Preparation of infectious sutures. The procedure employed was previously described (Taubler et al, 1962).…”

Section: Miaterials and I\iethodsmentioning

confidence: 99%

“…The standard deviation of with Institut Pasteur toxoid (see Materials and the regression line is 12.2% units, and the correla-Methods), or after giving human gammation coefficient is 0.51. globulin according to the previously described VOL. 86, 1963 53 TAUBLER, KAPRAL, AND NIUDD schedule (Taubler et al, 1962). In l latter cases, partial protection resull ever, from Table 2 it is evident that alpha-toxin (against purified toxin) a:…”

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ROLE OF ALPHA-TOXIN IN LESION FORMATION BY STAPHYLOCOCCUS AUREUS ON SUTURES SUBCUTANEOUSLY IMPLANTED IN MICE

1963

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Role of alpha-toxin in lesion formation by Staphylococcus aureus on sutures subcutaneously implanted in mice. J. Bacteriol. 86:51-57. 1963.-Evidence was obtained that alpha-hemolysin is essential for the development of purulent lesions by several strains of Staphylococcus aureus adsorbed onto sutures subcutaneously implanted in mice. This evidence consisted of findings that active immunization with staphylococcal toxoid afforded significant protection to subcutaneous challenge with this organism and that alpha-hemolysin-negative mutants, derived from strains ISZ and P78, were almost devoid of the ability to produce lesions by this route of infection. However, other unknown factors also appear to be essential for lesion formation since passive immunization of mice with antialpha-toxin, obtained from rabbits immunized with purified toxin, failed to afford protection. A dose-response curve for this type of infection is also presented.

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Uses of Hyperimmune Human Gamma Globulin

Kabat¹

1963

N Engl J Med

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Partial Protection of Mice by Human Gamma-Globulin Against Staphylococcus aureus on Subcutaneous Sutures.

Cited by 3 publications

References 0 publications

Serum Bacteriostasis of Staphylococcus aureus

Serum Bacteriostasis of Staphylococcus aureus

ROLE OF ALPHA-TOXIN IN LESION FORMATION BY STAPHYLOCOCCUS AUREUS ON SUTURES SUBCUTANEOUSLY IMPLANTED IN MICE

Uses of Hyperimmune Human Gamma Globulin

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