Partial Protection Induced by a BHV‐1 Recombinant Vaccine against Challenge with BHV‐5

Spilki, Fernando Rosado; Silva, Alessandra D.; Hübner, S.O.; Esteves, Paulo Augusto; Franco, Ana Cláudia; Driemeier, David; Roehe, Paulo Michel

doi:10.1196/annals.1307.038

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…In addition, the outcomes of the present study are in accordance with those of other studies [24], showing that the vaccination of pregnant cattle can prevent IBR-induced abortion. It is currently known [25,26] that other herpesviruses are involved in cattle abortion, but little information is available on the ability of vaccines prepared against BoHV-1 to protect against abortion induced by Bovine gammaherpesvirus 4 (BoHV-4) and Bovine alphaherpesvirus 5 (BoHV-5).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

et al. 2020

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Different types of vaccines against Infectious Bovine Rhinotracheitis (IBR) are commercially available. Among these, inactivated glycoprotein E (gE)-deleted marker vaccines are commonly used, but their ability to induce passive immunity is poorly known. Here, we evaluated the passive immunity transferred from dams immunised with commercial inactivated gE-deleted marker vaccines to calves. We vaccinated 12 pregnant cattle devoid of neutralising antibodies against Bovine alphaherpesvirus 1 (BoHV-1) and divided them into two groups with 6 animals each. Both groups were injected with a different inactivated gE-deleted marker vaccine administrated via intranasal or intramuscular routes. An additional 6 pregnant cattle served as the unvaccinated control group. After calving, the number of animals in each group was increased by the newborn calves. In the dams, the humoral immune response was evaluated before calving and, subsequently, at different times until post-calving day 180 (PCD180). In addition, the antibodies in colostrum, milk, and in serum samples from newborn calves were evaluated at different times until PCD180. The results indicated that inactivated glycoprotein E (gE)-deleted marker vaccines are safe and produce a good humoral immune response in pregnant cattle until calving and PCD180. Moreover, results showed that, in calf serum, passive immunity persists until PCD180.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

et al. 2020

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“…The efficacy of a gE negative BoHV-1 vaccine was tested against BoHV-5 infection. This vaccine was not protective in rabbits or cattle (Silva et al, 2006;Spilki et al, 2004). A recent study reported the immunogenicity and efficacy of inactivated BoHV-1 and BoHV-5 vaccines against BoHV-5 disease (Del Médico Zajac et al, 2006).…”

Section: Vaccinesmentioning

confidence: 99%

Biology of bovine herpesvirus 5

Zajac

Ladelfa

Kotsias

et al. 2010

The Veterinary Journal

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“…In North America, IBR vaccination is widely used and sporadic cases of BoHV-5 have only been seen to emerge in calves badly or not immunised against BoHV-1 [31]. A recombinant gE negative BoHV-1 vaccine has been shown to be unable to confer full protection against the challenge of BoHV-5 [117]. Therefore the efficacy of the cross-protection afforded by commercial BoHV-1 vaccines needs to be evaluated.…”

Section: Preventionmentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

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Partial Protection Induced by a BHV‐1 Recombinant Vaccine against Challenge with BHV‐5

Cited by 14 publications

References 6 publications

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

Evaluation of Passive Immunity Induced by Immunisation Using Two Inactivated gE-deleted Marker Vaccines against Infectious Bovine Rhinotracheitis (IBR) in Calves

Biology of bovine herpesvirus 5

Ruminant alphaherpesviruses related to bovine herpesvirus 1

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