Partial plasma exchange transfusion in polycythaemic neonates

Rothenberg, Tammy

doi:10.1136/adc.86.1.60

Archives of Disease in Childhood

2002

DOI: 10.1136/adc.86.1.60

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Partial plasma exchange transfusion in polycythaemic neonates

Tammy Rothenberg

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Cited by 7 publications

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“…In partialvolume exchange transfusions, whole blood is removed (not just plasma) and is exchanged for FFP or saline. 22,23 The Seventh Edition of the American Society for Apheresis Guidelines on the Use of Therapeutic Apheresis in Clinical Practice provides recommendations on the use of TPE in a wide variety of conditions including sepsis with multiorgan failure. 24 The potential benefits of TPE in septic shock include the reversal of multiple organ dysfunction syndrome (MODS) and thrombocytopenia-associated multiorgan failure (TAMOF).…”

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confidence: 99%

Therapeutic Plasma Exchange in Neonatal Septic Shock: A Retrospective Cohort Study

et al. 2019

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Objective This study aimed to examine the use of therapeutic plasma exchange (TPE) as adjunctive therapy in neonatal septic shock. Study Design This retrospective cohort study was performed on a convenience sample of neonates in a quaternary children's hospital between January 2018 and February 2019. Results We identified three neonates with septic shock who received TPE. Two neonates had adenovirus sepsis, and one had group B streptococcal sepsis. All neonates were on extracorporeal life support (ECLS) when TPE was started. The median duration of TPE was 6 days (interquartile range [IQR]: 3–15), with a median of four cycles (IQR: 3–5). Lactate levels decreased significantly after TPE (median before TPE: 5.4 mmol/L [IQR: 2.4–6.1] vs. median after TPE: 1.2 mmol/L [IQR: 1.0–5.8]; p < 0.001). Platelet levels did not change (median before TPE: 73,000/mm3 [IQR: 49,000–100,000] vs. median after TPE: 80,000/mm3 (IQR: 62,000–108,000); p = 0.2). Organ failure indices improved after TPE in two of the three neonates. Hypocalcemia was seen in all cases despite prophylactic calcium infusions. One neonate died, and two survived to ICU discharge. Conclusion TPE can be safely performed in neonates with septic shock. TPE may have a role as an adjunctive therapy in neonates with septic shock requiring ECLS.

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Therapeutic Plasma Exchange in Neonatal Septic Shock: A Retrospective Cohort Study

et al. 2019

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Pediatric hemostasis and use of plasma components

Goldenberg

Manco‐Johnson

2006

Best Practice & Research Clinical Haematology

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Neonatal polycythemia: is partial exchange transfusion justified?

Schimmel

Bromiker

Soll

2004

Clinics in Perinatology

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Partial plasma exchange transfusion in polycythaemic neonates

Cited by 7 publications

References 1 publication

Therapeutic Plasma Exchange in Neonatal Septic Shock: A Retrospective Cohort Study

Therapeutic Plasma Exchange in Neonatal Septic Shock: A Retrospective Cohort Study

Pediatric hemostasis and use of plasma components

Neonatal polycythemia: is partial exchange transfusion justified?

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