Partial molar volume of mefenamic acid in alcohol at temperatures between T=293.15 and T=313.15 K

Abstract

Volume molar aparente (V Φ ), volume molar parcial (V -), parâmetro de interação solutosoluto (S v ), expansividade molar parcial (E 0 2 ) e coeficiente de expansão térmica isobárica (α 2 ) do ácido mefenâmico em seis diferentes solventes orgânicos : metanol, etanol, 1-propanol, 2-propanol, 1-butanol e 2-butanol, foram calculados a partir das densidades das soluções medidas no intervalo de temperatura entre 293,15 e 313,15±0,1K. As densidades das soluções foram medidas por um densímetro automatizado (Anton Paar DMA-48). O intervalo de concentração investigado foi de 6,00 × 10 -3 a 3,25 × 10 -2 mol kg -1 . O efeito da temperatura sobre o volume molar aparente e o volume molar parcial foi também determinado. Um decréscimo nas interações soluto-solvente foi observado com o aumento da temperatura. O volume molar parcial do ácido mefenâmico também varia com a variação da polaridade do solvente. ) and isobaric thermal expansion coefficient (α 2 ) of mefenamic acid in six different organic solvents namely, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol, have been calculated from the measured solution densities over a temperature range of T=293.15 and T=313.15±0.1K. The solution densities were measured by an automated vibrating tube densitymeter (Anton Paar DMA-48). The molality range investigated was between 6×10 -3 and 3.25 ×10 -2 mol kg -1. The effect of temperature on apparent molar volume and partial molar volume was also determined. Decrease in solute-solvent interactions with an increase in temperature has been noted. Partial molar volume of mefenamic acid changes with the change in solvent polarity.

Thermodynamic study of three pharmacologically significant drugs: Density, viscosity, and refractive index measurements at different temperatures

“…The apparent molar volume, V / , was obtained from the density results using the following equation [3] V/ ¼…”

“…where T is the temperature and a, b, c were estimated by the leastsquare fitting method of V m in equation (3). To obtain the qualitative information on hydration of drugs, the values of Hepler's constant (oV m =oT 2 ) have been calculated and are included in table 2.…”

“…Doxycycline (DC) is an antibiotic [1]. This work is in continuation of a systematic investigation of volumetric and transport aspects of biochemical processes in various solvents [2][3][4][5]. In the present study, precise measurements of densities, viscosities, and refractive index of aqueous solutions of the drug compounds have been carried out at T = (293.15 to 313.15) K. The results retrieved through these measurements are used for the computation of different parameters, i.e.…”

Ultrasonic Speed and Thermodynamic Parameters of Novel Epoxy Resin Solutions Based on Cardo Symmetric Double Schiff Bases at 308.15 K

“…Epoxy resins are most widely used in land, marine and space transportation, automobile and electrical components, rehabilitation products, and pollution control equipment [18,19]. The characteristic properties of epoxy resins make them suitable for an increasing number of engineering applications such as those requiring high strength and stiffness, good dielectric behavior, resistance to chemicals, low shrinkage during cure, etc.…”

Volumetric, ultrasonic speed, and viscometric studies of salbutamol sulphate in aqueous methanol solution at different temperatures

“…From the partial molar volume V 0 / , the values of the isobaric thermal expansion coefficients of the solute at infinite dilution a 2 are also determined using the following equation (4) [16] and are given in table 3: TABLE 4 Velocity u, isentropic compressibility b s of SBS in aqueous methanol solution at different temperatures. …”