Partial molar pregnancy and coexisting fetus with Turner syndrome: Case report and literature review

Park, Ji Eun; Park, Ji Kwon; Cho, In Ae; Baek, Jong Chul

doi:10.5734/jgm.2018.15.1.43

Cited by 2 publications

(5 citation statements)

References 18 publications

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“…Hyperemesis, early onset preeclampsia and eclampsia ( 16 , 17 ), hyperthyroidism ( 11 ), unexplained intrauterine fetal demise ( 18 ) or fetal growth restriction, preterm labor or premature rupture of membranes ( 6 ), and pain in the lower abdomen, were the other presenting complaints. Rarely, cases attracted clinical attention due to positive first trimester screen or detection of cystic hygroma or fetal hydrops on USG examination ( 19 , 20 ). Partial mole may be detected incidentally on gross or pathologic examination of the placenta.…”

Section: Discussionmentioning

confidence: 99%

Partial mole with coexistent live fetus: A systematic review of case reports

Mangla¹,

Kaur²,

Khoiwal³

2022

J Turkish German Gynecol Assoc

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Objective: Molar pregnancy coexistent with a live fetus can be a diagnostic and therapeutic challenge. With increasing incidence of multiple pregnancies, there has also been an increase in twin pregnancy with one mole in the recent years. The authors discuss the epidemiology, clinical presentation, and prenatal diagnosis and attempt to design a possible management strategy, to help guide the treating physician, in the management of partial mole with live pregnancy, thereby improving maternal and fetal prognosis. Material and Methods: Numerous case reports have been published in various journals regarding management of individual cases of partial molar pregnancy coexistent with live fetus (PMCF). Therefore, we conducted a systematic review of all the case reports and short case series in English concerning partial mole with live pregnancy from 1999 to 2019, that is in the last 20 years. Results: In total, 44 case reports of PMCF were analyzed. The mean gestational age at diagnosis was 20+6 (range: 10-40) weeks. Less than half (19/44; 43.2%) were asymptomatic at the time of detection and PMCF was detected on routine scan done for fetal well-being or 11-13-week scan. The majority (56.8%) resulted in the birth of a healthy live fetus. Gestational trophoblastic neoplasia developed in 3/44 (6.8%). Conclusion: PMCF involves a high risk of bleeding, preterm labour, intrauterine growth restriction and stillbirth. Successful management of such cases needs prenatal diagnosis, antepartum surveillance and post-natal follow-up. An obstetrician, maternal fetal medicine specialist, gynecology oncologist and neonatal intensivist should be involved in the care of such pregnancies.

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Section: Discussionmentioning

confidence: 99%

Partial mole with coexistent live fetus: A systematic review of case reports

Mangla¹,

Kaur²,

Khoiwal³

2022

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

show abstract

“…Partial molar pregnancy with a coexisting fetus is a rare complication with an incidence of 0.005%-0.01% of all the pregnancies. 6 It usually derives from dispermic fertilization of the normal haploid oocyte and produces a triploid set of chromosomes. 4 Ultrasonography has made it possible to diagnose a hydatidiform mole and coexistent fetus in the first trimester.…”

Section: Discussionmentioning

confidence: 99%

“…4 Ultrasonography has made it possible to diagnose a hydatidiform mole and coexistent fetus in the first trimester. 6 Hydatidiform mole with coexistent normal fetus is not necessarily considered a partial mole. Cases of such association can be classified into three types.…”

Section: Discussionmentioning

confidence: 99%

“…4,8 In contrast, the last level b-hCG in this patient was 999.000mIU/ml indicates very high b-hCG, if we follow the serum b-hCG level greater than 106 mIU/mL based on Rahamni study, the TOP (termination of pregnancy) should be considered. 6 If the pregnancy does not stop, molar pregnancies with a normal fetus remain challenging. 4 Maternal risks should be explained to mother include information of abnormal bleeding, hyperemesis gravidarum, preeclampsia, eclampsia, hyperthyroidism, anemia, preterm labor, mal-presentation like a transverse lie, preterm premature rupture of membrane (PROM), persistent trophoblastic disease, and abruption.…”

Section: Discussionmentioning

confidence: 99%

“…Fetal complications include abortion, congenital anomalies, preterm, severe anemia due to limited placental circulation, IUGR, and intrauterine fetal death (IUFD). 6,9…”

Section: Discussionmentioning

confidence: 99%

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Partial molar pregnancy with live fetus in first trimester: what should we do next

Edwin¹,

Budihastuti²,

Elnita³

2020

JKS

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Abstract. The incidence of a normal live fetus with a partial mole is extremely rare, and it varies between 5 per 100000 and 1 per 10000 of the pregnancies. A partial molar pregnancy is a variation of a molar pregnancy in which an embryo either develops incompletely or with multiple structural anomalies.A 27-year-old Primigravide at 13 weeks of gestation got admitted with spotting per vaginam, excessive nausea and vomiting, and her ultrasound revealed a hydropic placenta with multiple cysts with a live fetus. Regarding these findings, the patient continued her pregnancy under close observation, and advanced sonographic evaluations were done to rule out other differentials. Ultrasonography found mosaicism in the partial mole (mostly diploid, a small part is triploid). In this condition, the prognosis condition for the fetus to be born safely is still probable. Ethics committee meetings are held with the consideration of the fetus's condition, whether monitoring is carried out regularly, and terminating the pregnancy in case of fetal emergency.The optimal management of hydatidiform mole with the coexistent live fetus is currently uncertain. Antenatal consultation should include a detailed discussion of maternal and fetal risks. It is also necessary to have close follow-up and evaluation of the patient's condition during the antenatal and postnatal period. Keywords: first trimester, live fetus , management, partial molar pregnancy

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Partial molar pregnancy and coexisting fetus with Turner syndrome: Case report and literature review

Cited by 2 publications

References 18 publications

Partial mole with coexistent live fetus: A systematic review of case reports

Partial mole with coexistent live fetus: A systematic review of case reports

Partial molar pregnancy with live fetus in first trimester: what should we do next

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