Partial Liquid Ventilation Ventilates Better than Gas Ventilation

Fujino, Yuji; Goddon, Sven; Chiche, Jean‐Daniel; Hromi, Jonathan; Kacmarek, Robert M.

doi:10.1164/ajrccm.162.2.9909036

Cited by 33 publications

(15 citation statements)

References 39 publications

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“…Many animal and clinical studies have demonstrated positive effects of either ESS alone or PLV alone on ALI induced by causes other than smoke inhalation (17)(18)(19)(20)(21)(22)(23)(24). Additionally, several studies with newborn or premature animals have shown the beneficial effects of a combined therapy of ESS and PLV on ALI induced by repeated saline lavage (25)(26)(27)(28)(29).…”

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confidence: 99%

Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets

Jeng

Kou

Sheu

et al. 2003

Critical Care Medicine

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confidence: 99%

Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets

Jeng

Kou

Sheu

et al. 2003

Critical Care Medicine

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“…Liquid-assisted ventilation, filling the lungs with PFC liquids during mechanical ventilation, including TLV and PLV, has proven effective in treating acute respiratory failure of premature, neonatal, and adult lungs (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The properties of different PFC liquids influence physiologic and cellular responses during PLV and affect the dosing strategy (1, 2); however, there are a limited number of PFC fluids appropriate for respiratory applications.…”

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confidence: 99%

Perfluorochemical (PFC) Combinations for Acute Lung Injury: An In Vitro and In Vivo Study in Juvenile Rabbits

et al. 2003

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Perfluorochemical (PFC) fluids of different physical properties were titrated and tested in vitro for physical properties that are appropriate for respiratory application. Two PFC liquids were studied: perfluoromethylcyclohexane (PP2), a liquid with high vapor pressure and low viscosity, and perfluoromethyldecalin (PP9), a fluid with low vapor pressure and high viscosity. Eighteen rabbits (2.05 Ϯ 0.07 kg; mean Ϯ SEM) were lunglavaged and randomized: group I, control group; group II, partial liquid ventilation with 75% PP2 and 25% PP9; group III, partial liquid ventilation with 50% PP2 and 50% PP9; and group IV, partial liquid ventilation with 25% PP2 and 75% PP9. Ventilator volumes were kept constant during the 4-h experiment. Cardiopulmonary measurements were performed every 30 min. The lung histology was examined. The in vitro study showed PFC [viscosity/vapor pressure (in cS and mm Hg, respectively)] as follows: 100% PP2 (0.88/141); 100% PP9 (3.32/2.9); 75% PP2 and 25% PP9 (1.26/107); 50% PP2 and 50% PP9 (1.63/13.7); and 25% PP2 and 75% PP9 (2.21/4.4). The in vivo experiments found that combinations of moderate vapor pressure (groups 3 and 4) demonstrated good gas exchange, compliance, and histo- The use of PFC as a medical material has been investigated during the past decades (1, 2). Liquid-assisted ventilation, filling the lungs with PFC liquids during mechanical ventilation, including TLV and PLV, has proven effective in treating acute respiratory failure of premature, neonatal, and adult lungs (1-11). The properties of different PFC liquids influence physiologic and cellular responses during PLV and affect the dosing strategy (1, 2); however, there are a limited number of PFC fluids appropriate for respiratory applications. Although several PFC liquids have been reported for liquid-assisted ventilation, including TLV and PLV (10, 12-18), there have been no studies exploring the effects of combining different PFC liquids to produce a fluid with optimum physical properties for respiratory therapy.All PFC liquids are immiscible to water, but they are soluble in each other (1). A PFC liquid suitable for respiratory application has the properties of high gas solubility and moderate vapor pressure and viscosity (2). Inasmuch as only a few PFC liquids are good candidates as a respiratory medium, a mixture

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“…Twenty donor dogs were submitted to general anesthesia (thiopental sodium and fentanyl citrate) and were maintained on mechanical ventilation, as previously described by Andrade et al (8) The following ventilation parameters were adjusted with the use of a pathologist, who was blinded to the protocol, as well as to the region from which the sample was obtained, and who used a histological scoring system. (12) The statistical analysis was performed with the Statistical Package for the Social Sciences, version 10.0 (SPSS Inc., Chicago, IL, USA). The parametric Student's t-test for independent samples was used in order to compare the groups with each other, and the values obtained are expressed as means and standard deviations.…”

Section: Methodsmentioning

confidence: 99%

Influência da estratégia ventilatória no desempenho funcional de enxertos pulmonares em um modelo experimental de transplante pulmonar unilateral de doadores após parada cardiocirculatória

et al. 2010

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Objective: To compare the influence of two different ventilation strategies-volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV)-on the functional performance of lung grafts in a canine model of unilateral left lung transplantation using donor lungs harvested after three hours of normothermic cardiocirculatory arrest under mechanical ventilation. Methods: The study comprised 40 mongrel dogs, randomized into two groups: VCV and PCV. Of the 20 recipients, 5 did not survive the transplant, and 5 died before the end of the post-transplant assessment period. The remaining 10 survivors (5 in each group) were evaluated for 360 min after lung transplantation. The functional performance of the grafts was evaluated regarding respiratory mechanics, gas exchange, and lung graft histology. Results: There were no significant differences between the groups regarding respiratory mechanics (peak inspiratory pressure, plateau pressure, mean airway pressure, dynamic compliance, and static compliance) or gas exchange variables (PaO 2 , venous oxygen tension, PaCO 2 , venous carbon dioxide tension, and the arterial-venous oxygen content difference). The histopathological findings were consistent with nonspecific acute lung injury and did not differ between the groups. Conclusions: This model of lung transplantation showed that the functional performance of lung grafts was not influenced by the ventilation strategy employed during the first six hours after reperfusion.Keywords: Pulmonary ventilation; Respiration, artificial; Lung transplantation; Dogs; Organ preservation. ResumoObjetivo: Comparar a influência de duas estratégias ventilatórias -ventilação controlada a volume (VCV) e ventilação controlada a pressão (VCP) -no desempenho funcional de enxertos pulmonares em um modelo canino de transplante pulmonar unilateral esquerdo, utilizando-se doadores cujos pulmões foram captados após três horas de parada cardiocirculatória em temperatura ambiente e sob ventilação mecânica. Métodos: O estudo incluiu 40 cães mestiços randomizados nos grupos VCV e VCP. Dos 20 receptores, 5 não sobreviveram ao transplante, e 5 não sobreviveram ao período de avaliação pós-transplante. Os 10 receptores sobreviventes (5 em cada grupo) foram avaliados durante 360 min após o término do transplante pulmonar. O desempenho funcional dos enxertos foi estudado através da avaliação da mecânica respiratória, trocas gasosas e histologia do enxerto. Resultados: Não houve diferenças significativas entre os grupos quanto às variáveis de mecânica respiratória (pressão de pico inspiratória, pressão de platô, pressão média de vias aéreas, complacência dinâmica e complacência estática) e de trocas gasosas (PaO 2 , pressão venosa mista de oxigênio, PaCO 2 , pressão venosa mista de CO 2 e diferença arteriovenosa de oxigênio). As alterações histopatológicas foram compatíveis com o padrão de lesão pulmonar aguda não específica e não diferiram entre os grupos. Conclusões: Este modelo de transplante pulmonar mostrou que o desempenho funcional do...

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Partial Liquid Ventilation Ventilates Better than Gas Ventilation

Cited by 33 publications

References 39 publications

Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets

Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets

Perfluorochemical (PFC) Combinations for Acute Lung Injury: An In Vitro and In Vivo Study in Juvenile Rabbits

Influência da estratégia ventilatória no desempenho funcional de enxertos pulmonares em um modelo experimental de transplante pulmonar unilateral de doadores após parada cardiocirculatória

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