Partial Kluver-Bucy Syndrome: Two Cases

Abstract

Kluver-Bucy syndrome (KBS) is a rare neuropsychiatric disorder that may be characterized by visual agnosia, placidity, altered sexual activity, hypermetamorphosis, and hyperorality. Patients with KBS present with a complex behavioral syndrome. KBS is usually associated with lesions of the amygdala or amygdaloid pathways. However, partial KBS may occur in the absence of the classic bilateral temporal lesions. Pharmacologic treatment options have been developed from the results of case reports, which suggest that carbamazepine and antipsychotics may be helpful. We present the cases of two patients with partial KBS who responded favorably to antipsychotic medication.

Partial Klüver–Bucy syndrome in a Paediatric patient: A post‐neurosurgical and neuropsychological cases

“…The presentation of this syndrome is not homogeneous but typically includes hyperorality, hyperphagia, indiscriminate dietary behaviour, hypersexuality, apathy, visual agnosia, distractibility, emotional and memory impairment, and excessive visual attentiveness, known as hypermetamorphosis (Bertoux et al, 2018; Jha & Ansari, 2010; Juliá‐Palacios et al, 2018; Lippe et al, 2013). Latchminarine et al (2022) define classic KBS as including all of the cardinal symptoms, and partial Klüver–Bucy syndrome (pKBS) as including three cardinal symptoms or other symptoms, could be diagnosed if the temporal neocortex or amygdala is affected in the absence of the bilateral classic temporal lesion (Bhat et al, 2009; Carroll et al, 2001), and it can occur at any age (Lippe et al, 2013). The major symptoms reported in children (Table 1) are the presence of emotional impairment (lability, irritability, mood swings, and excessive joy), aggressiveness, attentional difficulties due to hypermetamorphosis, and indifference towards peers and parents; the variability of the symptoms in children could be associated with the immaturity of some neural networks and lack of learning of some behaviours (Lippe et al, 2013).…”

A case report of Partial Kluver - Bucy Syndrome with Anterior Opercular syndrome in childhood: A sequel of limbic encephalitis

“…Kluver Bucy Syndrome rarely presents with all the classic symptomatology described. It frequently presents with few of the classic symptoms and is known as partial Kluver Bucy Syndrome [6,7]. In partial Kluver Bucy Syndrome, there may not be involvement of the bilateral temporal lobes unlike classic Kluver Bucy Syndrome [6,7].…”

“…It frequently presents with few of the classic symptoms and is known as partial Kluver Bucy Syndrome [6,7]. In partial Kluver Bucy Syndrome, there may not be involvement of the bilateral temporal lobes unlike classic Kluver Bucy Syndrome [6,7]. For the management of impulsive and disinhibited behavior of Kluver Bucy Syndrome, pharmaco-therapeutic agents like Carbamazepine, atypical antipsychotics (Risperidone, Quetiapine, Olanzapine, Aripiprazole) and selective serotonin reuptake inhibitors like Sertraline has been used successfully [6 -9].…”