Partial Hydrogenation of Alkynes to cis‐Olefins by Using a Novel Pd⁰–Polyethyleneimine Catalyst

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

“…The trans counterpart of the resulting diphenylethenyl moiety is related to the fully-methoxylated derivative of resveratrol (3,5,4’-trihydroxystilbene), a compound exhibiting diverse biological activities [23–24]. The chemo- and stereoselective semihydrogenation of internal alkynes may be achieved by two main catalytic methods: with molecular hydrogen using Lindlar’s catalyst [25–26] or by transfer hydrogenation with hydrogen donors [27–28]. Additionally, alkynes undergo reduction with diimide to produce cis -alkenes [29].…”

Development of Molecular Sieves‐Supported Palladium Catalyst and Chemoselective Hydrogenation of Unsaturated Bonds in the Presence of Nitro Groups

“…[6] As an extension of these methods, we prepared the isolable amine-and sulfur-poisoned catalysts; i.e., the Pd/C-ethylenediamine complex [Pd/C(en)], [7] Pd-polyethyleneimine complex (Pd/PEI). [8] and Pd/C-diphenyl sulfide complex [Pd/CA C H T U N G T R E N N U N G (Ph 2 S)], [9] for the chemoselective hydrogenations (Figure 1). Furthermore, we also developed a silk fibroin, a protein produced by silkworms possessing very few residues of sulfur-containing amino acids, a supported Pd-catalyst, and a Pd-fibroin complex (Pd/Fib), [10] as the selective hydrogenation catalyst of C-C or N-C multiple bonds in the presence of many other reducible functionalities as summarized in Figure 1.…”

“…The chemoselective hydrogenation between the nitro groups and multiple bonds as well as azide groups (entries 1-5) was completely achieved. Other reducible functionalities such as the aryl bromide, N-Cbz and benzyl ester were also tolerated under these conditions (entries [6][7][8].…”

Synthesis of Highly Selective Nano-Structured Functionalized Sba-15 Metformin Palladium Composite Catalyst in Partial Hydrogenation of Alkynes

“…In recent years, application and designing of highly selective catalyst for partial hydrogenation of alkynes has attracted more attention by virtue of its importance in synthesis of intermediate products [5][6][7][8][9] . The Lindlar catalyst (the Pd on the CaCO 3 poisoned with lead (II) acetate) was the first instance of highly selective supported metal catalyst for liquid phase partial hydrogenation of alkynes to alkenes by utilizing of a suitable surface modifier basic compound such as quinoline.…”