Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice
Jooyeop Lee,
Min Joo Kim,
Seoil Moon
et al.
Abstract:Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice. Current study examined if partial deletion of <i>Perk</i> (<i>Perk</i><sup>+/-</sup>) recapitulated the effects of PERK inhibitor, on the contrary to the complete deletion. <i>Perk</i><sup>+/-</sup> mice and wild-type controls were fed with a high-fat d… Show more
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