Partial deficiency of red cell 6-phosphogluconate dehydrogenase: A family study

Abstract

A family with partial deficiency of erythrocytic 6PGD is described. Biochemical and electrophoretic analysis suggest that the partial deficiency is due to a silent PGD0 allele. Chromosomal analysis and assay of closely linked markers do not reveal a grossly detectable deletion.

Examination of Changes in Enzyme Activities of Erythrocyte Glucose 6‐Phosphate Dehydrogenase and 6‐Phosphogluconate Dehydrogenase in Rats Given Naringenin and Lead Acetate

“…Wernicke–Karsokoff syndrome resulting in the absence of thiamine and memory loss and partial paralysis is also related to changes in the activity of transketolase in the pentose phosphate pathway . Anemia results in the deficiency of enzymes such as G6PD and 6‐phosphogluconate dehydrogenase (6PGD), which are key enzymes for the pentose phosphate pathway .…”