Partial characterization of an analog of pyridinoline isolated from human skin

Tilson, M. David; Dreyer, Robert N.; Hudson, Angela Pulley; Cotter, Robert J.; Tanzer, Marvin L.

doi:10.1016/0006-291x(85)90316-x

Cited by 15 publications

(6 citation statements)

References 3 publications

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“…Finally, the recent discovery of analogues of pyridinoline in human skin suggests the possibility of a browning mechanism based on lysyl oxidase-mediated modification of lysyl residues (18). Increased lysyl oxidase activity (19), as well as lysyl oxidasemediated cross-linking of collagen, have been documented in experimental diabetes (20).…”

Section: Discussionmentioning

confidence: 99%

Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.

Monnier¹,

Elmets²,

Frank³

et al. 1986

J. Clin. Invest.

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The age-related changes in collagen-linked fluorescence (browning) were investigated in skin from subjects with long-standing type I diabetes. Overall browning rates were 2A times higher in diabetics than in controls (P < 0.02) and slope intercept accurately reflected the mean age of onset of diabetes (11.6 vs. 11.2 yr), suggesting that the browning process has the attributes of a biological clock. Browning rates were not different in controls and diabetics without retinopathy (P > 0.05) but were 2.4 (P < 0.05) and 2.7 (P < 0.01) times increased in the presence of background and proliferative retinopathy, respectively. Compared with subjects with retinopathy, individual browning rates since onset of diabetes decreased with advancing age in subjects free ofretinopathy (P < 0.001). Extrapolation revealed that they would become identical to that of nondiabetic subjects by the age of 66A yr.These results suggest the presence of a mechanism that controls the browning rate ofcollagen in diabetics who do not develop retinopathy.

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Section: Discussionmentioning

confidence: 99%

Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.

Monnier¹,

Elmets²,

Frank³

et al. 1986

J. Clin. Invest.

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“…Cii, have also been reported, lysylpyridinium (LP), a fluorescent cross-link derived from two residues of hydroxylysine and one residue of lysine (13), and a so-called pyridinium analog found in skin (14). Details of the chemical structures and reaction pathways of these cross-links have been described by Yamauchi and Mechanic (12).…”

Section: =C-ciimentioning

confidence: 99%

Enzymatic and nonenzymatic cross‐linking of collagen and elastin

1992

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Knowledge regarding the steps and mechanisms related to the intra- and interchain cross-linking of collagen and elastin has evolved steadily during the past 30 years. Recently, effort has been directed at identifying the location and types of cross-links that are found in collagen and elastin. There are two major groups of cross-links: those initiated by the enzyme lysyl oxidase and those derived from nonenzymatically glycated lysine and hydroxylysine residues. The formation of enzymatic cross-links depends on specific enzymes, amino acid sequences, and quaternary structural arrangements. The cross-links that are derived nonenzymatically occur more adventitiously and are important to pathobiological processes. Considerable progress has been made in elucidating the pathways of synthesis for several of the enzymatically mediated cross-links, as well as possible mechanisms regulating the specificity of cross-linking. Although less is known about the chemistry of cross-links arising from nonenzymatically glycated residues, recent progress has also been made in understanding possible biosynthetic pathways and control mechanisms. This review focuses on such progress and hopes to underscore the biological importance of collagen and elastin cross-linking.

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“…4 Further confounding our hypothesis, the initial results on Pyr 5 were in conflict with our second data set, which was based on a larger number of patients and an improved high-performance liquid chromatography (HPLC) methodology developed in our laboratory. 6 Accordingly, a second paper was written to bring the record up to date. 7 Thereafter, we abandoned copper metabolism as a failed hypothesis, but we retained an interest in the X chromosome as a candidate locus.…”

Section: Timp1mentioning

confidence: 99%

The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm

Tilson

2006

Annals of the New York Academy of Sciences

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There are two approaches to gene discovery for diseases when genetic susceptibility has been implicated by clinical genetic or case-control studies: (1) genome-wide screening and (2) evaluation of candidate genes. Each has specific advantages and disadvantages. The principal advantage of genome-wide screening is that it is impeccably objective in as much as it proceeds without any presuppositions regarding the importance of specific pathobiological features of the disease process. The principal disadvantage is that such a study is expensive and resource intensive. A large population of enrolled patients and multidisciplinary teams of investigators cooperating from several institutions are usually required. The alternative approach of evaluating candidate genes can be pursued by a small independent laboratory with limited funding and resources, a small collection of clinical specimens, and a small number of team players. The disadvantage is that it is by necessity highly subjective in the process of selecting specific candidates among many reasonable possibilities. There is no a priori assurance that effort will not be expended on one or more candidates that turn out in the end to be failures. This report reviews efforts in our laboratory to evaluate four genes as candidates. One of these tissue inhibitor of metalloprotease 1(TIMP1) led to the description of a polymorphism, but not a conclusive mutation. The other three (HLA-DR-15, ferritin light chain (FTL), and collagen XI-alpha-1 (COL11A1) are subjects of continuing interest.

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Partial characterization of an analog of pyridinoline isolated from human skin

Cited by 15 publications

References 3 publications

Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.

Age-related normalization of the browning rate of collagen in diabetic subjects without retinopathy.

Enzymatic and nonenzymatic cross‐linking of collagen and elastin

The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm

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