1975
DOI: 10.1099/00222615-8-4-465
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Partial Characterisation of an Inhibitor of Streptolysin O Produced by Bacterialgrowth in Serum

Abstract: THE antistreptolysin 0 test is a reliable indicator of streptococcal infection. Non-specific inhibition of streptolysin 0 is uncommon but has been described in viral hepatitis and in jaundice. Free cholesterol inhibits streptolysin 0 in low concentration (Hewitt and Todd, 1939), but cholesterol in normal serum is not inhibitory (Watson, Rose and Kerr, 1972). However, we have encountered occasional false positive antistreptolysin tests where the sera have been contaminated with bacteria. Nevertheless, it must b… Show more

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Cited by 8 publications
(2 citation statements)
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“…The excellent ability of free cholesterol to neutralize SO has been recognized. In fact it is thought that because most cholesterol in serum is not in the free state, serum itself (in the absence of antibody) is a poor inhibitor of SO unless the serum is contaminated by bacteria that produce an enzyme such as cholesterol esterase or possibly a proteolytic enzyme which might free the cholesterol or alter the spatial relationship of cholesterol in lipoprotein fragments (31). Liver, as well as others of the tissues tested, does contain cholesterol in several forms, including free cholesterol.…”
Section: Inhibition Of Antigenicitymentioning
confidence: 99%
“…The excellent ability of free cholesterol to neutralize SO has been recognized. In fact it is thought that because most cholesterol in serum is not in the free state, serum itself (in the absence of antibody) is a poor inhibitor of SO unless the serum is contaminated by bacteria that produce an enzyme such as cholesterol esterase or possibly a proteolytic enzyme which might free the cholesterol or alter the spatial relationship of cholesterol in lipoprotein fragments (31). Liver, as well as others of the tissues tested, does contain cholesterol in several forms, including free cholesterol.…”
Section: Inhibition Of Antigenicitymentioning
confidence: 99%
“…Epidemiol Infect (in press). 3 Chapman PA, Mitchelmore DL. A two-year survey of the incidence of heat-labile enterotoxin-producing…”
mentioning
confidence: 99%