Partial breast irradiation: An updated consensus statement from the American brachytherapy society

Anderson, Bethany; Arthur, Douglas W.; Hannoun‐Lévi, Jean‐Michel; Kamrava, Mitchell; Khan, Atif J.; Kuske, Robert R.; Scanderbeg, Daniel J.; Shah, Chirag; Shaitelman, Simona F.; Showalter, Timothy N.; Vicini, Frank A.; Wazer, David E.; Yashar, Catheryn M.

doi:10.1016/j.brachy.2022.07.004

Cited by 21 publications

(14 citation statements)

References 126 publications

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“…Shortening the treatment time, reducing the normal tissue volume irradiated, and improving quality of life are major challenges already accomplished by multicatheter interstitial brachytherapy APBI [ 10 , 11 , 15 , 16 ]. This de-scalation in treated volumes should be strictly restricted to appropriately selected patients following the guideline recommendations of ESTRO [ 12 ], ASTRO [ 13 ], and ABS [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer

Rodríguez-Ibarria,

Pinar,

García

et al. 2024

Cancers

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Patients with an early carcinoma of the breast are commonly treated by breast-conserving surgery (BCS) and postoperative radiotherapy. Partial-breast irradiation has gained acceptance in the last few years. Between December 2008 and December 2017, 182 low-risk breast cancer patients treated by BCS in the four university hospitals of the province of Las Palmas and treated with APBI using interstitial multicatheter brachytherapy were included in this study. After a mean follow-up for survivors of 10 years, the treatment was shown to be safe, as no severe acute/late toxicity (grade ≥ 3) was observed. The 10-year IBTR was 1.7% (95%CI: 0.7–2.7%), and the cause-specific survival was 94.9% (95%CI: 93.2–96.6%). We suggest that multicatheter brachytherapy after BCS is safe and effective in early breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer

Rodríguez-Ibarria,

Pinar,

García

et al. 2024

Cancers

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“…This is applicable not only for primary tumors, but also for cases of recurrence after a second conservative treatment [ 1 , 2 ]. Breast brachytherapy, encompassing accelerated partial breast irradiation (APBI) [ 3 ] or as a boost after whole breast radiation therapy (WBRT) [ 4 - 6 ], has been firmly established for selected patients, as recommended by international guidelines [ 7 - 10 ]. After a second conservative treatment, such as accelerated partial breast re-irradiation (APBrl) [ 11 ], it is also offered to patients with an ipsilateral breast tumor recurrence (IBTR) as salvage therapy.…”

Section: Purposementioning

confidence: 99%

Post- versus intra-operative implant for breast cancer interstitial brachytherapy: How to choose?

Gimeno-Morales,

Motisi,

Rodriguez-Spiteri

et al. 2024

jcb

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Purpose Breast brachytherapy (BB) represents an important radiation therapy modality in modern breast cancer treatments. Currently, BB is mainly used for accelerated partial breast irradiation (APBI), local boost after whole breast radiation therapy (WBRT), and as salvage re-irradiation after second lumpectomy (APBrl). Two multi-catheter interstitial brachytherapy (MIB) techniques can be offered: intra-operative (IOB) and post-operative (POB) brachytherapy. The aim of this article was to summarize current available data on these two different brachytherapy approaches for breast cancer. Material and methods A literature search was performed, and different experiences published by BB expert teams were analyzed and compared. These two different brachytherapy approaches for breast cancer have also been presented and discussed during meetings of the GEC-ESTRO BCWG. In addition, expert recommendations were defined. Results A comprehensive description and practical comparison of both the techniques, i.e., IOB and POB, considering the latest available published data were presented. Different technical, logistic, and clinical aspects of both the methods were thoroughly examined and analyzed. This detailed comparison of the two breast brachytherapy techniques was supported by scientific data from extensive experience of experts, facilitating an objective analysis that, to our knowledge, has not been previously published. Conclusions Based on the comprehensive analysis of both the brachytherapy techniques available, this article serves as a valuable resource to guide breast teams in selecting the optimal BB technique (POB or IOB), considering hospital environment, multi-disciplinary collaboration, and patient logistics.

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“…OS, specific cause, local control, freedom from distant metastasis, and percentage of conversion to mastectomy are similar to total breast irradiation with 3D conformal RT 186 . Partial irradiation techniques include intraoperative RT, brachytherapy, and external conformal or intensity-modulated RT; each one with its respective dosimetric specifications and prescription regimens 187 . Outside of a clinical trial, candidates for partial breast irradiation include those aged ≥ 50 years, luminal subtype, ≤ 3 cm, absence of lymphovascular invasion, grade 1-2 invasive carcinoma, low-intermediate grade DCIS (≤ 2.5 cm with ≥ 3-mm margins), unicentric or unifocal lesion, negative margins (> 2 mm), negative lymph nodes (including isolated tumor cells), with no use of systemic therapy or neoadjuvant CT.…”

Section: Accelerated Partial Breast Irradiationmentioning

confidence: 99%

Mexican breast cancer consensus. Management of early breast cancer

Bargalló-Rocha,

Aguilar-Villanueva,

Ahumada-Pámanes

et al. 2024

GAMO

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Breast cancer, in early stages, has specific surgical, radiotherapy, and systemic management. This type of cancer includes ductal carcinoma in situ and breast cancers in stages I, IIA, IIB, and IIIA. This tenth update of the Mexican Breast Cancer Consensus addressed the management of early stages. The dissemination of this consensus contributes to the updating and homogeneity of breast cancer management criteria. This article aims to present the update in the multidisciplinary management of breast cancer.

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Partial breast irradiation: An updated consensus statement from the American brachytherapy society

Cited by 21 publications

References 126 publications

Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer

Ten-Year Results of Accelerated Partial-Breast Irradiation with Interstitial Multicatheter Brachytherapy after Breast-Conserving Surgery for Low-Risk Early Breast Cancer

Post- versus intra-operative implant for breast cancer interstitial brachytherapy: How to choose?

Mexican breast cancer consensus. Management of early breast cancer

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