Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly

Fonseca, Jorge M.; Rushing, James W.; Rajapakse, Nihal C.; Thomas, Robert; Riley, Melissa B.

doi:10.1016/j.jplph.2004.09.010

Cited by 18 publications

(9 citation statements)

References 40 publications

(45 reference statements)

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“…Also in hairy root culture of Cichorium intybus, another plant species from the Asteraceae, the contents of different sesquiterpene lactones including crepidiaside B, 8-deoxylactucin and sonchuside A were affected by MJ and SA treatments, for example the content of sonchuside A transiently increased (Malarz et al 2007), consistent with the transient increase of parthenolide in our study. The extent of parthenolide accumulations due to MJ or SA treatments in this report was comparable with that observed in 2, 4-D-treated feverfew plants at 2 and 14 days after treatment (2.5-fold increase); but the high level of parthenolide in 2, 4-D treated plants was maintained for 2 weeks (Fonseca et al 2005). Our results also showed that parthenolide accumulation was affected by MJ and SA, but with a different intensity which was higher in MJ-treated plans (3.1 fold) compared with SA-treated plants (1.96 fold).…”

Section: Discussionsupporting

confidence: 85%

“…Parthenolide has attracted considerable attention due to its application in medicine as a migraine prophylaxis agent, anti-inflammatory and anti-cancer compound (Saranitzky et al 2009;Watson et al 2009). Several studies have been carried out on factors affecting parthenolide biosynthesis, e.g., genotypes, developmental stages, environmental factors and chemical compounds such as 2, 4-D (Majdi et al 2013;Fonseca et al 2005).…”

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confidence: 99%

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Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium

2015

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Up-regulation of germacrene A synthase and down-regulation of parthenolide hydroxylase genes play key role in parthenolide accumulation of feverfew plants treated with methyl jasmonate and salicylic acid. Parthenolide is an important sesquiterpene lactone due to its anti-migraine and anti-cancer properties. Parthenolide amount was quantified by high-performance liquid chromatography after foliar application of methyl jasmonate (100 µM) or salicylic acid (1.0 mM) on feverfew leaves in time course experiment (3-96 h). Results indicate that exogenous application of methyl jasmonate or salicylic acid activated parthenolide biosynthesis. Parthenolide content reached its highest amount at 24 h after methyl jasmonate or salicylic acid treatments, which were 3.1- and 1.96-fold higher than control plants, respectively. Parthenolide transiently increased due to methyl jasmonate or salicylic acid treatments until 24 h, but did not show significant difference compared with control plants at 48 and 96 h time points in both treatments. Also, the transcript levels of early pathway (upstream) genes of terpene biosynthesis including 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 1-deoxy-D-xylulose-5-phosphate reductoisomerase and hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase and the biosynthetic genes of parthenolide including germacrene A synthase, germacrene A oxidase, costunolide synthase and parthenolide synthase were increased by methyl jasmonate and salicylic acid treatments, but with different intensity. The transcriptional levels of these genes were higher in methyl jasmonate-treated plants than salicylic acid-treated plants. Parthenolide content measurements along with expression pattern analysis of the aforementioned genes and parthenolide hydroxylase as side branch gene of parthenolide suggest that the expression patterns of early pathway genes were not directly consistent with parthenolide accumulation pattern; hence, parthenolide accumulation is probably further modulated by the expression of its biosynthetic genes, especially germacrene A synthase and also its side branch gene, parthenolide hydroxylase.

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Section: Discussionsupporting

confidence: 85%

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confidence: 99%

Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium

2015

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“…ABA was higher in water stressed plants and during late morning. Shading plants during afternoon resulted in increased levels of ABA (Fonseca et al, 2005a). The same ABA diurnal pattern, having a peak at late morning, was reported previously in peach trees (Correia et al, 1997).…”

Section: Feverfew Quality As Affected By the Environmentsupporting

confidence: 84%

“…The effect of light was evaluated by harvesting plants at different times of the day. The lowest amount of PRT was observed in plants harvested at night and the maximum level was observed during late afternoon (Fonseca et al, 2005a). Moreover, plants exposed to artificial light during night hours had increased PRT (Fonseca et al, 2003).…”

Section: Feverfew Quality As Affected By the Environmentmentioning

confidence: 99%

Potential Implications of Medicinal Plant Production in Controlled Environments: The case of Feverfew (Tanacetum parthenium)

Fonseca¹,

Rushing²,

Rajapakse³

et al. 2006

HortSci

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The purpose of this review is to promote a discussion about the potential implications of herb production in controlled environments, focusing on our recent works conducted with feverfew. Research suggests that the content of secondary metabolites in medicinal plants fluctuates with changing environmental conditions. Our studies with feverfew (Tanacetum parthenium [L.] Schultz-Bip., Asteraceae) lend support to this hypothesis. Feverfew plants exposed to different water and light conditions immediately before harvest exhibited changes in content of some secondary metabolites. The highest yield of parthenolide (PRT) was in plants that received reduced-water regimes. Phenolics concentration however, was higher in plants receiving daily watering. Light immediately before harvest enhanced accumulation of PRT, but reduced the phenolic content. Notably, PRT decreased at night whereas total phenolics decreased during the photoperiod and increased at night. PRT also increased with increased plant spacing. UV light supplementation increased PRT only in plants that had undergone water stress, whereas phenolics increased when UV was applied to continuosly watered plants. Clearly, production of medicinal plants under greenhouse conditions is a promising method for controlling levels of phytochemicals through manipulation of light and water as discussed here, and possibly other environmental factors such as temperature and daylength. However, better understanding of how the environment alter secondary metabolite levels is needed as it was revealed that manipulating the environment to favor increased accumulation of one group of phytochemicals could result in a decline of other key metabolites.

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“…with terpenes in essential oils (Vaverkova et al, 2008). Many studies have been published about the composition of essential oils (Gallino, 1988;Uchio et al, 1981;De Pooter et al, 1988;Goren et al, 2001;Williams et al, 1999;Baser et al, 2001;Gallori et al, 2001;Akpulat et al, 2005;Fonseca et al, 2005). In one of them (Stoianova-Ivanova et al, 1983) the analysis of steam distilled flowers and leaves as well as the whole aerial part of T. indicum L. was described.…”

Section: Introductionmentioning

confidence: 99%

Environmental adaptibility of tansy (Tanacetum vulgare L.)

Stevović¹,

Mikovilovic²,

́-Dragosavac³

2009

Afr. J. Biotechnol.

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Ecological role of essential oils is reflected in the interaction of plants with environmental factors. Environmental adaptability of the plants can be assumed from essential oil contents. Essential oils are agents, which communicate with the plant environment. Tansy (Tanacetum vulgare L.) was selected for laboratory research since it belongs to urban flora and vegetation where the imperative to adapt is high. Sample plants were collected from two site locations: Ada Huja (industrial zone) and Top ider (green area) in Belgrade, Serbia. A GC-MS analyses, to determine quantitative and qualitative composition of essential oils were used. The results of the research indicate that tansy from both locations shows a high degree of adaptability. Tansy from Ada Huja had larger total amount of essential oils comparing to plants from Top ider. This study presents the comparative results of laboratory research. Specific components of the essential oil samples of plants from both site locations are identified.

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Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly

Cited by 18 publications

References 40 publications

Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium

Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium

Potential Implications of Medicinal Plant Production in Controlled Environments: The case of Feverfew (Tanacetum parthenium)

Environmental adaptibility of tansy (Tanacetum vulgare L.)

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