Part-per-trillion LC-MS/MS determination of neonicotinoids in small volumes of songbird plasma

Hao, Chunyan; Eng, Margaret L.; Sun, Fengrong; Morrissey, Christy A.

doi:10.1016/j.scitotenv.2018.06.317

Cited by 35 publications

(14 citation statements)

References 57 publications

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“…Importantly, in our first experiment we had low but detectable concentrations of imidacloprid in some of our baseline fecal samples, similar to Hao et al (2018) in commercially obtained domestic chickens, yet our analytical and laboratory blanks were clean. First, we tested the feed for contamination and did not detect imidacloprid.…”

Section: Discussionmentioning

confidence: 75%

“…Thus, blood samples would need to be collected from birds captured almost immediately after exposure, and thus, many individuals that had been exposed to imidacloprid would test negative <2 d after exposure. However, residues of imidacloprid, thiacloprid, thiamethoxam, and acetamiprid have been detected in plasma of wild-caught white-crowned sparrows (Zonotrichia leucophrys), so blood can be useful in some field applications (Hao et al 2018). Further work is warranted to evaluate the relative performance of whole blood, which contains nAChR-bearing cells (Wang et al 2003), compared with serum, in reflecting imidacloprid exposure.…”

Section: Discussionmentioning

confidence: 99%

“…However, linking changes in these parameters to neonicotinoid exposure is difficult in wild animals. Making the exposure-to-effect linkage in the field requires, at a minimum, a method to detect recent exposure (Hao et al 2018;Humann-Guilleminot et al 2019); even so, drawing conclusions is complicated by other variables that can influence these parameters in the absence of neonicotinoid exposure. Currently, specific biomarkers are not available to indirectly indicate exposure.…”

Section: Introductionmentioning

confidence: 99%

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Sublethal and Lethal Methods to Detect Recent Imidacloprid Exposure in Birds with Application to Field Studies

Roy

Jankowski

Ponder

et al. 2020

Enviro Toxic and Chemistry

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We used domestic chickens (Gallus gallus domesticus) as a model for granivorous birds to identify methods to detect recent imidacloprid exposure in wild birds. We conducted dosing experiments of 1, 5, 10, and 20% of a reported median lethal dose for domestic chickens using repeated daily exposures over 7 d, at dosages equating to 1.04, 5.2, 10.4, and 20.8 mg/kg/d. We examined the parent compound and metabolites in serial collections of feces and blood during exposures and for 15 d after exposures. We also collected liver, kidney, brain, muscle, and spleen at the experiment end. Mean concentrations of parent compound at 15 d postexposure were highest in the feces and brain, followed by the liver, muscle, spleen, and kidney; but mean concentrations of metabolites 5‐OH‐imidacloprid and imidacloprid‐olefin were highest in feces; then liver, spleen, muscle, and kidney; and then brain. Imidacloprid was rapidly cleared from blood, with only one individual in any dose group having detectable concentrations after 48 h. In contrast, fecal pellets had the highest frequency of imidacloprid detection after 15 d. Concentrations of metabolites were higher than those of the parent compound at all sampling times examined but provided no information about time since exposure. Feces may provide a reliable nonlethal method for detection of recent imidacloprid exposure in wild birds. Additional work is needed to disentangle exposure dose concentration and time since exposure in field‐collected samples. Environ Toxicol Chem 2020;39:1355–1366. © 2020 SETAC

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sublethal and Lethal Methods to Detect Recent Imidacloprid Exposure in Birds with Application to Field Studies

Roy

Jankowski

Ponder

et al. 2020

Enviro Toxic and Chemistry

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“…(2016) observed 30 species consuming NN-treated seeds in recently drilled fields [16]. Furthermore, NN residues have been detected in two wild passerine species [20, 27], and in the eggs, crops and livers of wild partridges [28, 29]. A detailed review conducted by the American Bird Conservancy calculated that as few as 3.9 and 1.3 imidacloprid-coated wheat seeds could produce lethal and sub-lethal (reproductive) effects, respectively, if ingested by a 15-g bird [11].…”

Section: Introductionmentioning

confidence: 99%

Using long-term datasets to assess the impacts of dietary exposure to neonicotinoids on farmland bird populations in England

et al. 2019

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Over the last 20 years, a new group of systemic insecticides–the neonicotinoids—has gained prominence in arable systems, and their application globally has risen year on year. Previous modelling studies using long-term data have suggested that neonicotinoid application has had a detrimental impact on bird populations, but these studies were either limited to a single species or neglected to analyse specific exposure pathways in conjunction with observed population trends. Using bird abundance data, neonicotinoid usage records and cropping data for England at a 5x5 km resolution, generalised linear mixed models were used to test for spatio-temporal associations between neonicotinoid use and changes in the populations of 22 farmland bird species between 1994 and 2014, and to determine whether any associations were explained by dietary preferences. We assigned farmland bird species to three categories of dietary exposure to neonicotinoids based on literature data for species diets and neonicotinoid residues present in dietary items. Significant estimates of neonicotinoid-related population change were obtained for 13 of the 22 species (9 positive effects, 4 negative effects). Model estimates for individual species were not collectively explained by dietary risk categories, so dietary exposure to neonicotinoids via ingestion of treated seeds and seedlings could not be confirmed as a causal factor in farmland bird declines. Although it is not possible to infer any generic effect of dietary exposure to neonicotinoids on farmland bird populations, our analysis identifies three species with significant negative estimates that may warrant further research (house sparrow Passer domesticus, skylark Alauda arvensis and red-legged partridge Alectoris rufa). We conclude that there was either no consistent effect of dietary exposure to neonicotinoids on farmland bird populations in England, or that any over-arching effect was not detectable using our study design. The potential for indirect effects of insecticide use on bird populations via reduced food availability was not considered here and should be a focus for future research.

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“…Because treated seeds represent a potential food source for granivorous birds that forage on agricultural fields, concerns have been raised regarding the potential for avian consumption of treated seed and toxicological implications ( Bro et al, 2016 ; Lopez-Antia et al, 2015 ; Millot et al, 2017 ; Turaga et al, 2016 ). In addition, recent publications have reported detectable residues of some neonicotinoids in plasma or liver samples obtained from wild birds ( Hao et al, 2018 ; MacDonald et al, 2018 ). However, no studies have investigated the potential exposure and toxicological implications associated with the use of clothianidin as a corn seed treatment specifically, a major use of clothianidin in North America.…”

Section: Introductionmentioning

confidence: 99%

Field evaluation of the potential for avian exposure to clothianidin following the planting of clothianidin-treated corn seed

McGee

Åslund

Duca

et al. 2018

PeerJ

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The objective of this study was to quantify consumption of clothianidin-treated corn seed by birds following standard planting practices. Based on post-planting seed counts on 21 fields in southwestern Ontario, Canada, between 29 and 813 seeds/ha (mean of 224 ± 167 (SD)) were estimated to remain on the soil surface immediately post planting (i.e., less than one seed per 10 m2). This represents between 0.03 and 1.2% of the total sown seeds. The number of seeds missing on each field on the third day after planting as a result of any process (e.g., removal by foraging birds or mammals or burial as a result of heavy rains) ranged from 0 to 136 seeds/ha (0 to 0.0136 seeds/m2). Behavior monitoring of individual birds and 24 h remote video surveillance were deployed to investigate how much of the treated seed remaining on the soil surface was consumed by birds. Spotting scopes were used to monitor the full duration of the field visits of 596 individual birds during morning hours for three consecutive days after planting on the 21 fields. Two birds were observed consuming treated seeds (one seed each) and three birds consumed seeds for which the treatment status could not be visually confirmed. Additionally, constant (24 h) video surveillance for 2–4 days immediately after planting was deployed at 24 areas where multiple treated seeds were found on the soil surface. Across 1,380 h of collected video footage (including both day and night periods), no birds were observed to consume any treated seeds. This study provides field evidence of two factors that determine exposure of birds to clothianidin-treated corn seeds: (1) standard sowing practices in Ontario are effective at burying treated seeds such that the proportion of sown seeds that remain on the soil surface after planting is low, and (2) birds monitored on these fields consumed very few of the clothianidin-treated corn seeds remaining on the soil surface after planting. As these results are dependent on planting techniques and seed characteristics, they are not necessarily applicable to other types of clothianidin treated seed.

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Part-per-trillion LC-MS/MS determination of neonicotinoids in small volumes of songbird plasma

Cited by 35 publications

References 57 publications

Sublethal and Lethal Methods to Detect Recent Imidacloprid Exposure in Birds with Application to Field Studies

Sublethal and Lethal Methods to Detect Recent Imidacloprid Exposure in Birds with Application to Field Studies

Using long-term datasets to assess the impacts of dietary exposure to neonicotinoids on farmland bird populations in England

Field evaluation of the potential for avian exposure to clothianidin following the planting of clothianidin-treated corn seed

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