Part I: Fighting Cancer with Deadly Bacteria

Nybo, Kristie

doi:10.2144/000114624

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…He developed a "vaccine" ("Coley's toxins") composed of two killed bacterial species, Streptococcus pyogenes and Serratia marcescens, to simulate an infection with the accompanying fever without the risk of an actual infection [25][26][27]. As a result, prolonged or even complete regression of advanced malignancy was documented in some cases [1,23,28]. Moreover, mentioned above, T. Doyen tried to produce an anticancer "vaccine" from the "Micrococcus neoformans" he discovered [17].…”

Section: Scientists Make Bacterial "Anti-cancer Vaccines" Almost Blin...mentioning

confidence: 99%

Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?

Ikryannikova,

Gorokhovets,

Belykh

et al. 2023

IJMS

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Bacteria are the constant companions of the human body throughout its life and even after its death. The history of a human disease such as cancer and the history of microorganisms, particularly bacteria, are believed to closely intertwined. This review was conceived to highlight the attempts of scientists from ancient times to the present day to discover the relationship between bacteria and the emergence or development of tumors in the human body. Challenges and achievements of 21st century science in forcing bacteria to serve for cancer treatment are considered. The future possibilities of bacterial cancer therapy, including the creation of bacterial microrobots, or “bacteriobots”, are also discussed.

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Section: Scientists Make Bacterial "Anti-cancer Vaccines" Almost Blin...mentioning

confidence: 99%

Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?

Ikryannikova,

Gorokhovets,

Belykh

et al. 2023

IJMS

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“…In 1891, the physician Dr. William Coley was the first to use the bacteria and their toxins in the treatment of cases ending with cancer; he used live Streptococcus pyogenes and killed them by heating and injected them into his patients. After that, Dr. Coley was able to develop a safe vaccine composed of two of bacterial species after killing them that include Streptococcus pyogenes and Serratia marcescens; the vaccine was later called Coley's vaccine "Coley's toxin" which was widely used for different types of cancers such as carcinomas and lymphomas [10,142,143]. In initial tests, the bacterium Salmonella was injected into the solid tumor, where it was observed that the cancer cells were killed.…”

Section: Engineered Bacteria To Fightmentioning

confidence: 99%

Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition

Al-Hilu

Al-Shujairi

2020

International Journal of Microbiology

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Although what unifies the carcinogenic microorganisms has not been determined by multiple studies, the role of bacteria in the development of neoplasms has not been properly elucidated. In this review, we discuss links between the bacterial species and cancer, with focus on immune responses for the stimulation of tumor cells such as induction of inflammation. Finally, we will describe the potential therapeutic strategies of bacteria on target tumors to improve treatment while mitigating adverse reactions. Cancer is a series of genetic changes that transform normal cells into tumor cells. These changes come from several reasons, including smoking, drinking alcohol, sunlight, exposure to chemical or physical factors, and finally chronic infection with microorganisms, including bacteria. In fact, bacterial infections are not carcinogenic, but recently it was discovered that the association between bacteria and cancer is through two mechanisms, the first stimulating chronic inflammation and the second producing carcinogenic metabolites. While bacteria are carcinogenic agents also, they have a dual role eliminating and removing tumor cells. However, the traditional cancer treatments that include chemotherapy, radiotherapy, surgery, and immunotherapy increase the chances of survival, and there are many side effects of these therapies, including the high toxicity of tissues and normal cells, could not penetrate the tumor cells, and resistance of these therapies by tumor cells. Therefore, the world has turned to an alternative solution, which is the use of genetically engineered microorganisms; thus, the use of living bacteria targeting cancerous cells is the unique option to overcome these challenges. Bacterial therapies, whether used alone or combination with chemotherapy, give a positive effect to treat multiple conditions of cancer. Also, bacteria can be used as vectors for drug, gene, or therapy, and this is a great step to treat cancer. Thus, we review the mechanisms underlying the interaction of the microbiota residents with cancer. Cancer-associated bacteria differ from those in healthy human and are linked with gene-expression profile. We also discuss how live bacteria interact with tumor microenvironments to induce tumor regression through colonization and spread. Finally, we provide past and ongoing clinical trials that include bacteria targeting tumors.

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“…As well as cells B, cancer cells carrying the "best genes" are able to duplicate and expand easily than others. At the level of the organism, it is almost impossible that the immunological system reacts and fights against cancer cells because this is part of the same organism [4]. Therefore, it is remarkably hard to produce an immunological response.…”

Section: Can We Have Some Technological Advances Base On the Selfish ...mentioning

confidence: 99%

“…Genes that are able to match antigens, duplicate easily and expand under a cellular cloning process. Indeed, a vaccine is any substance that stimulates the production of antibodies [4] and provides immunity against microbial infections. In fact, these cells have different genomes.…”

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confidence: 99%

The Molecular Approach behind Biotechnological Common Problems

Santos¹

2019

JBB

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A fascinating concept in biology, in my personal opinion, is how cells are able to make new cells expressing the information from genes to proteins all over the earth. From unicellular organisms, viruses, mycoplasma, protozoa, cancer cells, neurons to the most complex biological organisms and complex ecosystems, all of them rely on the gene expression. Darwin in his famous book "On the Origin of Species" in 1859, states that the species of organisms live and evolve through the natural selection processes. In 1976 Richard Dawkins states in his book "The Selfish Gene", that genes are the central piece in the way natural selection operates [1]. In this paper, I am going to explore the relationship between genes under the "selfish" rule and how these can inspire new technologies.

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Part I: Fighting Cancer with Deadly Bacteria

Abstract: A 200-year-old observation might provide a new way to eliminate tumors by infecting cancer patients with bacteria. Kristie Nybo explores a new approach that could transform cancer treatment.

Cited by 4 publications

References 5 publications

Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?

Bacterial Therapy of Cancer: A Way to the Dustbin of History or to the Medicine of the Future?

Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition

The Molecular Approach behind Biotechnological Common Problems

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