Part 9: Acute coronary syndromes

Bossaert, Leo; O’Connor, Robert E.; Arntz, Hans-Richard; Brooks, Steven C.; Diercks, Deborah; Feitosa-Filho, Gilson Soares; Nolan, Jerry P.; Hoek, Terry L. Vanden; Walters, D.; Wong, Aaron; Welsford, Michelle; Woolfrey, Karen

doi:10.1016/j.resuscitation.2010.09.001

Cited by 41 publications

(18 citation statements)

References 680 publications

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“…There was no adjunctive medication for resuscitation. Pigs were constantly evaluated and if required treated by current standards of emergency medicine and trauma surgery, that is, Acute Trauma Life Support (ATLS) and European Resuscitation Council (ERC) from 2010 [ 17 , 23 ]. These protocols allow standard techniques such as inserting chest tubes in case of pneumothoraces and draining blood from cardiac tamponade by needle punctures.…”

Section: Methodsmentioning

confidence: 99%

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Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Weuster

Mommsen

Pfeifer

et al. 2015

Mediators of Inflammation

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Background. The deterioration of hemodynamics instantly endangers the patients' life after polytrauma. As accidental hypothermia frequently occurs in polytrauma, therapeutic hypothermia still displays an ambivalent role as the impact on the cardiopulmonary function is not yet fully understood. Methods. We have previously established a porcine polytrauma model including blunt chest trauma, penetrating abdominal trauma, and hemorrhagic shock. Therapeutic hypothermia (34°C) was induced for 3 hours. We documented cardiovascular parameters and basic respiratory parameters. Pigs were euthanized after 15.5 hours. Results. Our polytrauma porcine model displayed sufficient trauma impact. Resuscitation showed adequate restoration of hemodynamics. Induced hypothermia had neither harmful nor major positive effects on the animals' hemodynamics. Though heart rate significantly decreased and mixed venous oxygen saturation significantly increased during therapeutic hypothermia. Mean arterial blood pressure, central venous pressure, pulmonary arterial pressure, and wedge pressure showed no significant differences comparing normothermic trauma and hypothermic trauma pigs during hypothermia. Conclusions. Induced hypothermia after polytrauma is feasible. No major harmful effects on hemodynamics were observed. Therapeutic hypothermia revealed hints for tissue protective impact. But the chosen length for therapeutic hypothermia was too short. Nevertheless, therapeutic hypothermia might be a useful tool for intensive care after polytrauma. Future studies should extend therapeutic hypothermia.

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Section: Methodsmentioning

confidence: 99%

“…We hypothesized that hemodynamics after polytrauma could benefit from mild therapeutic hypothermia. TH might be an important tool in trauma care as used in other fields of emergency care [ 2 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model

Weuster

Mommsen

Pfeifer

et al. 2015

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…An extensive review of many aspects of advanced life support was performed as part of the 2010 Consensus on Science process. [5][6][7][8][9][10][11] The information from this process has been incorporated into the following guidelines wherever appropriate.…”

Section: Definitionsmentioning

confidence: 99%

Introduction to Advanced Life Support. ARC and NZRC Guideline 2010

2011

Emerg Medicine Australasia

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“…There is insufficient evidence to support the use of many of these in isolation as primary tests to evaluate patients with symptoms suspicious for cardiac ischemia. 46,47 The diagnosis of AMI includes the increase and/or decrease in the biomarker troponin; therefore, numerous studies have evaluated the effectiveness of different timelines for ruling in an AMI by using various troponin assays. Many cardiology guidelines have recommended timelines for ruling in AMI.…”

Section: Introductionmentioning

confidence: 99%