2015
DOI: 10.1016/j.resuscitation.2015.07.044
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Part 6: Pediatric basic life support and pediatric advanced life support

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Cited by 93 publications
(70 citation statements)
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References 91 publications
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“…The use of epinephrine during CPR has been considered an essential element of pediatric resuscitation for over 50 years (22, 23). Recommendations by the American Heart Association and International Liaison Committee on Resuscitation (20, 21) with regards to use of epinephrine and additional vasoactive medications have been challenged recently as several reports have demonstrated poorer hospital survival and neurologic outcomes in the adult out-of-hospital cardiac arrest population receiving epinephrine (2428). Contrary to the recommended dosing of epinephrine until return of spontaneous circulation (every 3–5 min intervals), nearly one third of respondents in our survey reported limiting epinephrine doses, regardless of CPR duration (Fig.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The use of epinephrine during CPR has been considered an essential element of pediatric resuscitation for over 50 years (22, 23). Recommendations by the American Heart Association and International Liaison Committee on Resuscitation (20, 21) with regards to use of epinephrine and additional vasoactive medications have been challenged recently as several reports have demonstrated poorer hospital survival and neurologic outcomes in the adult out-of-hospital cardiac arrest population receiving epinephrine (2428). Contrary to the recommended dosing of epinephrine until return of spontaneous circulation (every 3–5 min intervals), nearly one third of respondents in our survey reported limiting epinephrine doses, regardless of CPR duration (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Of particular interest to the authors is the use of vasoactive medications, a key component of conventional CPR. Although data are lacking on drug choice, timing, and overall efficacy during CPR, the American Heart Association’s Pediatric Advanced Life Support (PALS) guidelines recommend administering epinephrine (1:10,000 concentration) IV/intraosseously every 3–5 minutes for the treatment of asystole and pulseless electrical activity (1921). To date, consensus guidelines have not addressed vasoactive dosing regimens during conventional CPR escalating to E-CPR.…”
mentioning
confidence: 99%
“…As noted, race/ethnicity or etiology of OHCA were not consistently available for analysis, but these types of data could be helpful to direct public health advocacy initiatives to prevent OHCA in children. Time to first epinephrine dose, a primary component of pediatric advanced life support, was associated with survival in a study of pediatric IHCA 20,21 . Interestingly, only 65% of children were given epinephrine by EMS in this study.…”
Section: Discussionmentioning
confidence: 99%
“…For children, consideration should be given to modifying the chain of survival to stress preventative measures for respiratory and cardiac arrest events, educational efforts for faster recognition and highest quality treatment performance of the deteriorating child by bystander and first responders, discovery of effective therapeutic interventions, and rehabilitative strategies 21,29 .…”
Section: Discussionmentioning
confidence: 99%
“…Epidemiological investigations often report resuscitation efforts of up to two hours [3, 29]. In the absence of a reversible cause and after asystole for more than 20 min despite ongoing ALS, the 2015 ERC-Guidelines recommend to consider withholding CPR [12, 30]. In our study, cumulative CPR-duration (sum of bystander and EMS-CPR) was known for 29 patients.…”
Section: Discussionmentioning
confidence: 89%