Part 1: CT characterisation of pancreatic neoplasms: a pictorial essay

Galvin, Angela; Sutherland, Tom; Little, Andrew F.

doi:10.1007/s13244-011-0102-7

Cited by 21 publications

(30 citation statements)

References 43 publications

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“…The size of the cysts ranges from 0.2 to 2.0 cm and the entire tumor measures 1.4–30 cm ( 3 , 11 , 17 , 18 ) . The lesion may grow locally leading to almost complete damage of the healthy pancreatic tissue ( 15 ) . In imaging examinations (US, CT), such a cystic tumor frequently has the appearance of a “honeycomb” which is related to a large number of small cysts ( fig.…”

Section: Discussionmentioning

confidence: 99%

“…Such tests help to detect a circumscribed fluid area in the region of the pancreas as well as estimate the thickness of its walls and evaluate its contents. Tracing the manner in which the cyst adheres to the gastrointestinal structures, vessels located in the vicinity of the pancreas and main visceral vessels is also significant since it is decisive when resection is considered ( 6 , 12 , 15 ) . Another test, which is currently more and more frequently recommended, is endoscopic ultrasound examination.…”

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confidence: 99%

“…Other lesions are: intraductal papillary mucinous neoplasm (IPMN), which accounts for 21–33% of cystic tumors and is usually detected at the age of 65, and the most rarely encountered – solid pseudopapillary neoplasm (SPN), which so far, has been detected in 600 patients – it develops mainly in women in their 30s or 40s ( 18 , 20 , 21 ) . Other rarely encountered lesions (< 1% of tumors) are: cystic non-functional islet tumors (NFITs), acinic cell cystadenocarcinomas, cystadenoma, cavernous angioma and lymphangioma, ganglioma as well as primary solid neoplasms which undergo cystic degeneration ( 13 , 15 , 18 ) .…”

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confidence: 99%

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Diagnostyka i leczenie torbieli rzekomych i guzów torbielowatych trzustki – na podstawie materiału własnego oraz przeglądu literatury

Ćwik¹,

Krupski²,

Zakościelny³

et al. 2013

J Ultrason

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Pseudocysts constitute the most basic cystic lesions of the pancreas. Symptomatic cysts may be treated by means of both minimally invasive methods and surgery. Currently, it is believed that approximately 5% of cystic lesions in the pancreas may in fact, be neoplastic cystic tumors. Their presence is manifested by generally irregular multilocular structures, solid nodules inside the cyst or in the pancreatic duct, frequently vascularized, as well as fragmentary thickening of the cystic wall or septation.AimThe aim of this paper was to present current management, both diagnostic and therapeutic, in patients with pancreatic pseudocysts and cystic tumors. The article has been written based on the material collected and prepared in the author's Department as well as on the basis of current reports found in the quoted literature.Material and methods, resultsIn 2000–2012, the Second Department of General, Gastrointestinal and Oncological Surgery of the Alimentary Tract treated 179 patients with cystic lesions in the region of the pancreas. This group comprised 12 cases of cystic tumors and 167 pseudocysts. Twenty-three patients (13.8%) were monitored only and 144 received procedural treatment. Out of the latter group, 75 patients underwent drainage procedures and 48 were qualified to endoscopic cystogastrostomy or cystoduodenostomy. The endoscopic procedure was unsuccessful in 11 cases (23%). In a group of patients with a pancreatic cystic tumor (12 patients), 6 of them (50%) underwent therapeutic resection of the tumor with adequate fragment of the gland.ConclusionsEndoscopic drainage is an effective and safe method of minimally invasive treatment of pancreatic cysts. The patients who do not qualify to endoscopic procedures require surgical treatment. The differentiation of a neoplasm from a typical cyst is of fundamental significance for the selection of the treatment method.

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Section: Discussionmentioning

confidence: 99%

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Diagnostyka i leczenie torbieli rzekomych i guzów torbielowatych trzustki – na podstawie materiału własnego oraz przeglądu literatury

Ćwik¹,

Krupski²,

Zakościelny³

et al. 2013

J Ultrason

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“…These are a group of islet cell tumours accounting for 1-5% of all pancreatic neoplasms 15 Primary carcinoid tumour of the pancreas is extremely rare and can present early with symptoms like flushing, abdominal pain, diarrhoea and weight loss. On CT most of them are hypo or isodense ( Figure 7A) enhancing in the arterial phase ( Figure 7B).…”

Section: Neuroendocrine Tumoursmentioning

confidence: 99%

Multidetector CT findings of pancreatic neoplasms with histopathological correlation: a pictorial essay

Botcha¹,

Rangasami²,

Johnson³

et al. 2015

Int Surg J

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Pancreatic neoplasms are one of the leading cause of death in the world. Multidetector computed tomography (MDCT) provides high resolution images and is useful in the detection and staging of pancreatic malignancies. The acquisition of images in arterial, venous and delayed phases improves the accuracy of diagnosing unresectable pancreatic carcinoma and also helps in identifying indirect signs of a mass with no visible pancreatic contrast in the form of atrophic distal parenchyma, interrupted duct sign and mass effect. This pictorial essay aims to depict characteristic appearance of various pancreatic neoplasms on 64 slice MDCT and their corresponding histopathological appearances.

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“…CT is the most common imaging modality of choice in staging and follow-up of unresectable pancreatic cancer. Tumor treatment response at CT is commonly assessed by tumor size [5][6][7] or attenuation changes [8][9][10]. Positron Emission Tomography (PET), however, has been shown to be more accurate for detection of pancreatic cancer in many studies, with overall accuracy of 91% versus 78% for contrast-enhanced CT [11] with comparable sensitivity [12].…”

Section: Introductionmentioning

confidence: 99%

Pilot Study: Two-Stage Hybrid Model to Correlate Single Energy CT and PET in Pancreatic Adenocarcinoma

Oldan¹

2014

J Health Med Informat

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Pancreas adenocarcinoma is one of the most common malignant tumors and the fourth leading cause of cancerrelated mortality. While Computed Tomography (CT) has been commonly used clinically for the cancer staging and follow-up, Positron Emission Tomography (PET) is known to be generally more accurate and sensitive for metastases and thus has great prognostic value. However, PET is more expensive and less accessible. This research is to explore the use of multivariate models to extract valuable information from CT to mimic the effects of PET. Based on the original 6 CT measures, 10 CT biomarkers are derived. The strongest correlation with PET SUV in the multivariate regression on the 6 original measures is r 2 =0.41 (r=0.64), on the 10 derived biomarkers is r 2 =0.55 (r=0.74). We developed a twostage hybrid model, where a multivariate classifier was developed to first separate the patients into the group with high SUV values vs. low SUV values, then the regression model was developed for each group respectively. The overall performance of this two-stage model is more promising with an r 2 =0.81 (r=0.90). We conclude advanced CT analytics has the potential to extract valuable information that correlates with PET SUV. Rationale and objectives: Pancreatic adenocarcinoma is commonly studied by CT and PET. We aimed to see if information from CT could be used to simulate the results of PET. Materials and methods: A retrospective study of 24 patients with pancreatic cancer who had both CT and PET in close temporal proximity was conducted. Measurements of the aorta, normal pancreatic tissue, solid and cystic portions of pancreatic tumors were performed resulting in 6 biomarkers. Ten more biomarkers were derived including the ratios of solid and cystic tumor mean and standard deviation to normal pancreas (and to each other), as well as signal-to-noise ratios of solid and cystic tumors to normal pancreas. Univariate analysis and multivariate regression were conducted on the original measures (6 biomarkers) and derived measures (10 biomarkers). A two-stage hybrid model integrating machine learning model with multivariate regression analysis was also studied. Results: The best results were obtained using the two-stage hybrid model. The regression model for low SUV (≤5) used cystic tumor mean (r 2 =0.68, r=0.83). The regression model for high SUV(>5) used tumor mean, the ratios of tumor mean to pancreas mean, tumor mean to aorta mean, standard deviation of tumor to aorta mean and signal-to-noise ratio of difference between the normal pancreas mean and solid tumor mean to standard deviation of pancreas (r 2 =0.86, r=0.93). The overall performance of the two-stage model is r 2 =0.81(r=0.90). Conclusion: Two-stage multivariate analysis of CT parameters can mimic the effects of PET to a reasonable extent, and signal-to-noise and standard deviation ratios may capture the essential nonlinearity of these relationships.

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Part 1: CT characterisation of pancreatic neoplasms: a pictorial essay

Cited by 21 publications

References 43 publications

Diagnostyka i leczenie torbieli rzekomych i guzów torbielowatych trzustki – na podstawie materiału własnego oraz przeglądu literatury

Diagnostyka i leczenie torbieli rzekomych i guzów torbielowatych trzustki – na podstawie materiału własnego oraz przeglądu literatury

Multidetector CT findings of pancreatic neoplasms with histopathological correlation: a pictorial essay

Pilot Study: Two-Stage Hybrid Model to Correlate Single Energy CT and PET in Pancreatic Adenocarcinoma

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