Part 1. A Refined Etiological Classification of Calcium Oxalate Urolithiasis Based on Calculi Studies

Daudon, Michel; Bader, Cyrille; Reveillaud, R. J.; Jungers, Paul

doi:10.1007/978-1-4615-2556-1_131

Cited by 36 publications

(91 citation statements)

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“…Interestingly, some of these calcifications present similarities to the structures reported in 6 physiological bone 17,21 or pathological biominerals. 3,22,23 Our study provides information for understanding the physico-chemical processes involved in the formation of pathological calcifications.…”

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confidence: 55%

“…In kidney, the spatial organization of the mineral phase is frequently linked to the pathology at the origin of their formation. 4,5 Kidney stones show a great chemical diversity 6,7 but the most common composition corresponds to calcium oxalate monohydrate, found in patients without any systemic disorder (so-called idiopathic stones). In many cases, [8][9][10] these stones originate from mineral deposits at the tip of renal papillae known as Randall's plaques (RPs).…”

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confidence: 99%

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Nanoscale Analysis of Randall’s Plaques by Electron Energy Loss Spectromicroscopy: Insight in Early Biomineral Formation in Human Kidney

et al. 2020

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Idiopathic kidney stones originate mainly from calcium phosphate deposits at the tip of renal papillae, known as Randall's plaques (RPs), also detected in most human kidneys without stones. However, little is known about the mechanisms involved in RP formation. The localization and characterization of such nano-sized objects in the kidney remains a real challenge making their study arduous. This study provides a nanoscale analysis of the chemical composition and morphology of incipient RPs, characterizing in particular the interface between the mineral and the surrounding organic compounds. Relying on data gathered from a calculi collection, the morphology and chemical composition of incipient calcifications in renal tissue was determined using spatially resolved electron energy-loss spectroscopy (EELS). We detected micro-calcifications and individual nano-calcifications found at some distance from the larger ones. Strikingly, concerning the smaller ones, we show that two types of nanocalcifications coexist: calcified organic vesicles and nanometric mineral granules mainly composed of calcium phosphate with carbonate in their core. Interestingly, some of these nanocalcifications present similarities with those reported in physiological bone or pathological cardiovascular biominerals, suggesting possible common formation mechanisms. However the high diversity of these nano-calcifications suggests that several mechanisms may be involved (nucleation on a carbonate core or on organic compounds). In addition, incipient RPs also appear to present specific features at larger scales revealing secondary calcified structures embedded in a fibrillar organic material. Our study proves that analogies exist between physiological and pathological biominerals and provides information to understand the physico-chemical processes involved in pathological calcification formation.

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confidence: 55%

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confidence: 99%

Nanoscale Analysis of Randall’s Plaques by Electron Energy Loss Spectromicroscopy: Insight in Early Biomineral Formation in Human Kidney

et al. 2020

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“…Although cystine is known as only one crystalline phase in urine, two different stone morphologies, Va and Vb, have been described in patients, with two different behaviours when treated by ESWL (Bhatta et al, 1989;Daudon et al, 1993). To explain this difference, we investigated the structural characteristics of these two types of stones at the macroscopic, mesoscopic and nanometric scales.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, two morphological types of cystine kidney stones (KS), namely Va and Vb, may be distinguished (Bhatta et al, 1989;Daudon et al, 1993;Kim et al, 2005), on the basis of their surface characteristics as observed through a stereomicroscope. As previously described, the surface of the first kind of stones (type Va, Fig.…”

Section: Introductionmentioning

confidence: 99%

Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale?

et al. 2014

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International audienceWith an incidence of 1:7000 births, cystinuria, the most frequent cause of stone formation among genetic diseases, represents a major medical problem. Twentyfive cystine stones randomly selected from cystinuric patients were investigated. From a crystallographic point of view, cystine stones are composed of micrometre size crystallites, which are made up of an aggregation of nanocrystals. Through scanning electron microscopy, the morphology and size of the crystallites have been described, while the size of the nanocrystals was investigated by means of powder neutron diffraction. Powder neutron diffraction analysis and/or scanning electron microscopy examination of cystine stones provide evidence that usual alkalinization by sodium bicarbonate associated with high diuresis significantly reduces the size of both nanocrystals and crystallites, while for other treatments, including alkalinizing drugs and thiol derivatives, the data suggest mainly changes in the topology of crystallites. Alkalinization with sodium bicarbonate affects cystine kidney stones at the mesoscopic and nanoscopic scales, while other medical treatments only alter their surface. Such an approach may help to assess the interaction between drugs and cystine stones in cystinuric patients

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“…Regarding UA urinary stones, the classification performed through their morphology as well as by FourierTransform InfraRed (FT-IR) spectroscopy [68,69] distinguishes two morphological types, namely IIIa and IIIb, each being related to specific conditions [28]. For example, the surface of IIIa type stones is homogeneous, smooth or slightly embossed.…”

Section: Samplesmentioning

confidence: 99%

Type 2 diabetes and uric acid stones: A powder neutron diffraction investigation

Daudon

Letavernier

Weil

et al. 2015

Comptes Rendus. Chimie

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a b s t r a c tRecent epidemiologic investigations have identified an association between type 2 diabetes and uric acid kidney stones. This association was more apparent in women than in men. In this paper, we show through powder neutron diffraction that particle sizes of uric acid kidney stones were significantly different between male and female patients (84.7 ± 5.3 vs. 140.2 ± 6.7 nm, p ¼ 0.000003). Interestingly, when type 2 diabetes appeared, this structural difference between male and female vanished (76.1 ± 3.9 vs. 78.8 ± 4.2 nm, not significant). Thus, the complete set of structural data is in line with observations regarding epidemiological data. Some explanations based on supersaturation are discussed.

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Part 1. A Refined Etiological Classification of Calcium Oxalate Urolithiasis Based on Calculi Studies

Cited by 36 publications

References 0 publications

Nanoscale Analysis of Randall’s Plaques by Electron Energy Loss Spectromicroscopy: Insight in Early Biomineral Formation in Human Kidney

Nanoscale Analysis of Randall’s Plaques by Electron Energy Loss Spectromicroscopy: Insight in Early Biomineral Formation in Human Kidney

Therapy modifies cystine kidney stones at the macroscopic scale. Do such alterations exist at the mesoscopic and nanometre scale?

Type 2 diabetes and uric acid stones: A powder neutron diffraction investigation

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