Parsonage-Turner Syndrome Following COVID-19 Vaccination: Clinical and Electromyographic Findings in 6 Patients

Shields, Lisa B.E.; Iyer, Vasudeva G.; Burger, John T.; Shields, Christopher B.

doi:10.1159/000521462

Cited by 17 publications

(25 citation statements)

References 20 publications

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“…CIDP is also reported as a possible consequence of vaccination, again with the majority of cases associated with adenovirus-based products (153)(154)(155). Brachial neuritis is also described as a post-vaccination complication in several reports (156)(157)(158), including patients receiving mRNA vaccines and usually ipsilateral to the side of vaccination (159). Inflammatory myopathy has also been reported in isolated cases as a side effect of vaccination, causing syndromes resembling poly/dermatomyositis (160) or localized myositis near the site of inoculation (161), There are also case reports of SARS-CoV-2 vaccine associated with varicella zoster reactivation (162), although at present a relationship is not clearly established (163).…”

Section: Vaccination Against Sars-cov-2 and Neuromuscular Complicationsmentioning

confidence: 99%

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

et al. 2022

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In this article we review complications to the peripheral nervous system that occur as a consequence of viral infections, with a special focus on complications of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We discuss neuromuscular complications in three broad categories; the direct consequences of viral infection, autoimmune neuromuscular disorders provoked by viral infections, and chronic neurodegenerative conditions which have been associated with viral infections. We also include discussion of neuromuscular disorders that are treated by immunomodulatory therapies, and how this affects patient susceptibility in the current context of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is associated with direct consequences to the peripheral nervous system via presumed direct viral injury (dysgeusia/anosmia, myalgias/rhabdomyolysis, and potentially mononeuritis multiplex) and autoimmunity (Guillain Barré syndrome and variants). It has important implications for people receiving immunomodulatory therapies who may be at greater risk of severe outcomes from COVID-19. Thus far, chronic post-COVID syndromes (a.k.a: long COVID) also include possible involvement of the neuromuscular system. Whether we may observe neuromuscular degenerative conditions in the longer term will be an important question to monitor in future studies.

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Section: Vaccination Against Sars-cov-2 and Neuromuscular Complicationsmentioning

confidence: 99%

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

et al. 2022

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“…According to a case report, PTS cases increased during the first 6 months of 2021, which was later found to be related to COVID-19 vaccination. [ 4 ] Whereas the current literature shows cases from Italy and the United States, this manuscript illustrates one of the few, if not the first, reports of PTS following COVID-19 vaccination in India. Therefore, practitioners in India should consider post-COVID-19 vaccination sequelae when dealing with cases of brachial neuritis.…”

Section: Discussionmentioning

confidence: 86%

Parsonage–Turner syndrome following COVID-19 vaccine

Sharma

Dua

Goyal

et al. 2022

Ann Indian Acad Neurol

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“…1,4,5 In children, it has also been described after immunization for diphtheria, tetanus, and pertussis. 5 To date, few cases have been described after COVID-19 vaccination, 7-15 none of them in the children. The time from vaccination until the onset of PTS symptoms has been described around 28 days.…”

Section: Discussionmentioning

confidence: 99%

Parsonage-Turner Syndrome After COVID-19 Vaccination in a Child

et al. 2023

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Parsonage-Turner syndrome (PTS) is a peripheral neuropathy involving the brachial plexus very rare in childhood. To date, no cases of PTS after COVID-19 vaccination have been reported in children. We report a case of a 15-year-old boy affected by PTS after the second dose of the BNT162b2 (Comirnaty, Pfizer-BioNTech) COVID-19 vaccine. Parsonage-Turner syndrome (PTS) is a rare peripheral neuropathy involving the brachial plexus characterized by sudden onset pain affecting the upper extremity associated with muscle weakness. With an estimated incidence of 1.64 cases per 100,000 people, 1 PTS usually develops in people aged between 20 and 60 years, being very rare in children.The diagnosis is based on clinical history, physical examination, electrophysiological study, and exclusion of other pathologies. The clinical picture of PTS is very diverse because a large variety of nerves can be affected. Muscle paresis commonly manifests as scapula alata, secondary to paresis of the muscles involved in scapular fixation. 2 Pain is the first symptom in 90% of patients, being the location of pain variable, but in most cases radiated from the cervical spine or shoulder region into the arm. 1 Electrodiagnostic testing is widely used to diagnose PTS. Abnormal sensory potentials, lack of denervation potentials, and abnormal conduction velocities are the most frequent findings.The etiology and pathophysiology of PTS still remain unclear. 3 Recent viral infections, such as herpes simplex virus, Epstein-Barr virus, cytomegalovirus, HIV, hepatitis B virus, and parvovirus B19 infections, have been reported as the probable trigger in 25% of patients with PTS. [4][5][6] Vaccination has been described to precede PTS in 4.3% to 15.5% of cases. 1,5 To date, only a few cases of PTS after COVID-19 vaccination have been reported, none of them in the childhood. [7][8][9][10][11][12][13][14][15] In this study, we report a case of a child affected by PTS after the second dose of COVID-19 vaccination. CaseA 15-year-old boy presented to the clinic because of acute pain and functional impotence in his left shoulder that started 1 week before. Physical examination revealed reduced range of motion for shoulder flexion and abduction because of weakness and pain. He had full flexion and extension of the wrist and fingers as well as hand interosseous muscles. Four weeks earlier, he had received the

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Parsonage-Turner Syndrome Following COVID-19 Vaccination: Clinical and Electromyographic Findings in 6 Patients

Cited by 17 publications

References 20 publications

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

Parsonage–Turner syndrome following COVID-19 vaccine

Parsonage-Turner Syndrome After COVID-19 Vaccination in a Child

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