Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS

Goerigk, Stephan; Padberg, Frank; Chekroud, Adam M; Kambeitz, Joseph; Bühner, Markus; Brunoni, André R.

doi:10.1016/j.brs.2021.05.008

Cited by 6 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Goerigk et al [83] randomized patients with major depressive disorder into an escitalopram group, a tDCS group, and a placebo group. In that study, tDCS was applied by placing the anode on L-DLPFC and by placing the cathode on R-DLPFC at 2 mA for 22 sessions.…”

Section: Psychiatric Disoredersmentioning

confidence: 99%

Application of Transcranial Direct Current Stimulation in Sleep Disturbances

et al. 2022

View full text Add to dashboard Cite

Sleep disturbances are common across all age groups, and they encompass a broad range of impairments of daytime functioning and comorbid various clinical conditions. However, current treatment methods for sleep disturbances have several limitations. As the ‘top-down’ pathway is known to play an important role in sleep-wake regulation, and as neuronal activity abnormalities have been reported as a potential pathological mechanism of sleep disturbances, the use of non-invasive brain stimulation—such as transcranial direct current stimulation (tDCS) in treating sleep disturbances—has emerged. In the present review, we first explain the mechanism of tDCS, and we also introduce recent studies that have applied tDCS to sleep disorders, along with other sleep-related tDCS studies. In conclusion, many studies have achieved improvements in sleep state, although some of these studies have reported inconsistent effects of tDCS according to the protocol and the conditions used. Further studies are needed to explore the optimal protocols to use when applying tDCS in each sleep disturbance and to enhance the evidence on the clinical efficacy of tDCS.

show abstract

Section: Psychiatric Disoredersmentioning

confidence: 99%

Application of Transcranial Direct Current Stimulation in Sleep Disturbances

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 12 Studies of differential symptom cluster response to brain stimulation including electroconvulsive therapy and transcranial direct current stimulation have also found that the core mood and dysphoric symptoms respond better to treatment than other symptom clusters. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Differential symptom cluster responses to repetitive transcranial magnetic stimulation treatment in depression

Kaster¹,

Downar²,

Vila‐Rodriguez³

et al. 2023

eClinicalMedicine

View full text Add to dashboard Cite

“…These studies have shown that core mood and dysphoric symptoms exhibit more favourable responses to treatment than other symptom clusters. In other words, interventions targeting brain regions associated with mood and dysphoria have demonstrated superior outcomes compared to addressing other symptom domains (Goerigk et al, 2021;Wade et al, 2020). Therefore, by employing total depression scores to assess treatment response, the ability to detect different responses among individual symptom clusters may be compromised (Fried & Nesse, 2015).…”

Section: Baseline Biomarkers and Association With Response To Tbs Tre...mentioning

confidence: 99%

Association between Levels of Cortical Excitation/Inhibition and Clinical Response to Theta Burst Stimulation in Individuals with Major Depressive Disorder

Kiaee

View full text Add to dashboard Cite

Introduction. Theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (TMS), is an effective treatment for major depressive disorder (MDD). TBS is thought to modulate cortical excitation and inhibition, which are thought to be implicated in the pathophysiology of MDD. This study assesses excitation/inhibition levels and investigates their potential link with TBS response. Methods. Thirty-seven MDD participants and thirteen healthy controls were recruited. TBS treatment was administered five days/week over 4-6 weeks. At baseline, a magnetic resonance spectroscopy (MRS) scan of the anterior cingulate cortex and TMS to the left motor cortex were performed to probe excitation/inhibition levels. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression (HRSD-17) score. Results. Cortical excitation was lower in MDD participants than in healthy controls, and baseline levels were linked to improvements in mood symptoms. Conclusion. Our results suggest that baseline cortical excitation could help predict TBS therapeutic response.Completing this journey has been such an amazing experience, all thanks to the unwavering support from some truly incredible individuals, who have my heartfelt gratitude. I would like to express my sincere gratitude to Drs. Sara Tremblay, and Alfonso Abizaid for their invaluable belief in me and the learning opportunities they provided. Their unwavering support and guidance have been my guiding light throughout this journey. I would also like to extend my gratitude to my family, with a special mention of my beloved spouse, Shayan.His enduring patience and unwavering encouragement have provided me with a solid foundation and constant support that I can always rely on. His presence has been a source of strength and reassurance throughout this journey, and I am truly thankful for his continuous belief in me. Expressing my appreciation towards my friends and the Nest Lab members, particularly Molly Watson and Jessica Drodge. Their invaluable mentorship and contributions are deeply appreciated. They have played crucial roles in providing a nurturing learning environment, for which I am truly grateful. I would like to express my thanks to my thesis committee members for generously devoting their time to assess my thesis and being present at my thesis defence. Lastly, I would like to express my gratitude to all my participants for participating in this research.

show abstract

Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS

Cited by 6 publications

References 36 publications

Application of Transcranial Direct Current Stimulation in Sleep Disturbances

Application of Transcranial Direct Current Stimulation in Sleep Disturbances

Differential symptom cluster responses to repetitive transcranial magnetic stimulation treatment in depression

Association between Levels of Cortical Excitation/Inhibition and Clinical Response to Theta Burst Stimulation in Individuals with Major Depressive Disorder

Contact Info

Product

Resources

About