PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population

Abstract

PARP-1 762Ala/Ala could be a risk factor for gastric cancer in Han Chinese population; PARP-1 762Val/Ala polymorphism and Cag(+) H. pylori infection jointly contribute to higher risk for gastric cancer.

Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Case-control Study

“…The effect of variability in genotype distribution, especially between China and distant European or American countries, also (Duarte et al, 2005) and Italy (Palli et al, 2010) found no evidence of a relationship between the XRCC1 Arg194Trp polymorphism and the development of GC, which may be due to much lower frequency of the 194Trp allele (generally lower than 15%) in these populations than those in China. ADPRT Val762Ala polymorphism was not statistically associated with noncardia GC in our study, which was inconsistent with three other studies on risk of cardia GC and GC in general Zhang et al, 2009) in Han Chinese. Reliable evidence exists for risk of prostate cancer (Lockett et al, 2004), lung cancer (Zhang et al, 2005) and esophageal cancer (Hao et al, 2004).…”

“…X-ray repair cross-complementing group 1 (XRCC1) and adenosine diphosphate ribosyl transferase (ADPRT) are two of many proteins involved in the BER pathway. Several genetic polymorphisms have been identified in both ADPRT and XRCC1 genes, of which XRCC1 Arg194Trp (C26304T) (Shen et al, 2000;Ratnasinghe et al, 2004;Liu et al, 2009;Shen et al, 2009;Yan et al, 2009;Yuan et al, 2010) and ADPRT Val762Ala (T2446C) Zhang et al, 2006;Zhang et al, 2009) have been widely studied for association with cardia and/or noncardia GC in the Chinese population, albeit with conflicting results reported.…”

Original article Poly(ADP-ribose) polymerase-1 (PARP1) and p53 labelling index correlates with tumour grade in meningiomas

“…The role of PARP1 has been described in other tumours such as breast [51], ovarian [6], pancreatic carcinomas [24], gastric carcinomas [62], prostate carcinomas [53], melanomas [13,40] and glioblastomas [12,21] but has not been investigated in meningiomas yet.…”

Helicobacter pylori infection promotes the invasion and metastasis of gastric cancer through increasing the expression of matrix metalloproteinase-1 and matrix metalloproteinase-10

“…H. pylori expresses cytotoxin-associated gene (Cag) A, which generates a cytotoxic effect and induces inflammatory and immune responses. The deformation and necrosis of mucosal cells and inflammatory infiltration can be observed in H. pylori -infected lesions, and specific antibodies can be detected in serum (4,5). …”