“…This condition is the latest of the purely electrical conditions of the heart to have a proven genetic basis, inherited as an autosomal dominant (59,60) or recessive (61) genetic disease. The clinical phenotype of bidirectional or polymorphic ventricular tachycardia occurring with physical or emotional stress in patients with structurally normal hearts and normal resting ECGs was first described in isolated case studies in the 1960s and 1970s (62)(63)(64). In 1978, Coumel et al (65) described a series of young patients presenting with catecholamine-induced polymorphic ventricular arrhythmias.…”
“…This condition is the latest of the purely electrical conditions of the heart to have a proven genetic basis, inherited as an autosomal dominant (59,60) or recessive (61) genetic disease. The clinical phenotype of bidirectional or polymorphic ventricular tachycardia occurring with physical or emotional stress in patients with structurally normal hearts and normal resting ECGs was first described in isolated case studies in the 1960s and 1970s (62)(63)(64). In 1978, Coumel et al (65) described a series of young patients presenting with catecholamine-induced polymorphic ventricular arrhythmias.…”
“…Ventricular tachycardia has been found in children and young adults with no detectable structural heart disease [2,4,6,7,9,10,14,15,[17][18][19]21,25,27,28,31,34,36] . The prognosis has varied, from benign to malignant .…”
Exercise tests were done on all patients referred to us because of ventricular premature beats. Exercise-associated ventricular tachycardia was seen in three of these patients. Once therapy for the arrhythmia was begun in two patients, we performed serial exercise tests, attempting to provoke the arrhythmia again. In the third patients, who was pregnant, we advised against strenuous physical activity and will exercise her post partum to determine whether therapy is warranted. We have shown that exercise testing can be used successfully in unmasking ventricular arrhythmias not detectable on resting evaluation.
“…[124][125][126][127] CPVT is not associated with organic heart diseases, and there is no sex difference in incidence. In patients with CPVT, exercise and intravenous isoproterenol induce a gradual increase in PVC, which further lead to polymorphic or bidirectional VT, very fast polymorphic VT (350 to 400/min), and finally to VF.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.