Paroxysmal Nocturnal Hemoglobinuria and the Myeloproliferative Syndrome

Voolen, G. Arthur Van

doi:10.7326/0003-4819-96-6-792

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Analysis of waterborne outbreaks and sporadic cases show that water is an important environmental reservoir for C. jejuni ( Bolton et al, 1982 ; Thomas et al, 1999 ; Huang et al, 2015 ). Contamination of surface water and well water may occur due to direct deposition of animal feces, sewage discharge and farmland run-offs ( Vogt et al, 1982 ; Lind et al, 1996 ; Clark et al, 2003 ; O’Reilly et al, 2007 ; Bronowski et al, 2014 ; Huang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and Transcriptomic Responses of Campylobacter jejuni Suspended in an Artificial Freshwater Medium

et al. 2017

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Campylobacter jejuni is the leading cause of campylobacteriosis in the developed world. Although most cases are caused by consumption of contaminated meat, a significant proportion is linked to ingestion of contaminated water. The differences between C. jejuni strains originating from food products and those isolated from water are poorly understood. Working under the hypothesis that water-borne C. jejuni strains are better equipped at surviving the nutrient-poor aquatic environment than food-borne strains, the present study aims to characterize these differences using outbreak strains 81116 and 81-176. Strain 81116 caused a campylobacteriosis outbreak linked to consumption of water, while strain 81-176 was linked to consumption of raw milk. CFU counts and viability assays showed that 81116 survives better than 81-176 at 4°C in a defined freshwater medium (Fraquil). Moreover, 81116 was significantly more resistant to oxidative stress and bile salt than strain 81-176 in Fraquil. To better understand the genetic response of 81116 to water, a transcriptomic profiling study was undertaken using microarrays. Compared to rich broth, strain 81116 represses genes involved in amino acid uptake and metabolism, as well as genes involved in costly biosynthetic processes such as replication, translation, flagellum synthesis and virulence in response to Fraquil. In accordance with the observed increase in stress resistance in Fraquil, 81116 induces genes involved in resistance to oxidative stress and bile salt. Interestingly, genes responsible for cell wall synthesis were also induced upon Fraquil exposure. Finally, twelve unique genes were expressed in Fraquil; however, analysis of their distribution in animal and water isolates showed that they are not uniquely and ubiquitously present in water isolates, and thus, unlikely to play a major role in adaptation to water. Our results show that some C. jejuni strains are more resilient than others, thereby challenging current water management practices. The response of 81116 to Fraquil serves as a starting point to understand the adaptation of C. jejuni to water and its subsequent transmission.

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Section: Introductionmentioning

confidence: 99%

Phenotypic and Transcriptomic Responses of Campylobacter jejuni Suspended in an Artificial Freshwater Medium

et al. 2017

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“…Η ΝΠΑ έχει περιγραφεί σε συνδυασμό κυρίως με ιδιοπαθή μυελοϊνωση [Hansen & Killman 1970, Lewis et al 1971, Hirai et al 1973, Christou et al 1987, Graham et al 1992, Nakahata et al 1993, καθώς επίσης και σε ασθενείς με αληθή πολυκυτταραιμία, χρόνια μυελογενή λευχαιμία (chronic myeloid leukemia, CML), ιδιοπαθή πολυκυτταραιμία [Boyd et al 1979, Hansen & Killmann 1970, Catovsky et al 1971, Kuo et al 1972, van Voolen et al 1982. Θετικές δοκιμασίες Ham και sucrose βρέθηκαν σε ένα ποσοστό αρρώστων με CML και ιδιοπαθή μυελοΐνωση και ασθενείς με άλλα MPDs [Hansen & Killman 1970, Catovsky et al 1971, Kuo et al 1972, ενώ σε μερικούς ασθενείς παρατηρήθηκαν εργαστηριακά δεδομένα αιμόλυσης χωρίς θετικές δοκιμασίες Ham και σουκρόζης [van Voolen et al 1982]. Ερυθρά αιμοσφαίρια με έλλειψη των CD55 και/ή CD59 έχουν ανιχνευθεί σε ασθενείς με MPDs [Meletis et al 1997, Terpos et al 1998b, Μελέτης & Τέρπος 1999, Τέρπος και συν 1999, Τέρπος και συν 2000α, Meletis et al 2001b, Meletis & Terpos 2003…”

Section: 3 3 δ δ μ μυ υε ελ λο οϋ ϋπ πε ερ ρπ πλ λα ασ στ τι ικ κά ά σ σύ ύν νδ δρ ρο ομ μα α κ κα αι ι ν νπ πα αunclassified

Μελέτη Των Υποπληθυσμών Ερυθροκυττάρων Τύπου ΝΠΑ Σε Ασθενείς Με Ρευματολογικά Νοσήματα Στην Διάγνωση, Την Πορεία Μετά Λήψη Ή Όχι Ανοσοκατασταλτικών Φαρμάκων

Ασημακόπουλος¹,

Asimakopoulos²

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Δ ΔΙ ΙΔ ΔΑ ΑΚ ΚΤ ΤΟ ΟΡ ΡΙ ΙΚ ΚΗ Η ΔΔΙ ΙΑ ΑΤ ΤΡ ΡΙ ΙΒ ΒΗ Η " "Μ Με ελ λέ έτ τη η τ τω ων ν υ υπ πο οπ πλ λη ηθ θυ υσ σμ μώ ών ν ε ερ ρυ υθ θρ ρο οκ κυ υτ ττ τά άρ ρω ων ν « «τ τύ ύπ πο ου υ Ν ΝΠ ΠΑ Α» » σ σε ε α ασ σθ θε εν νε εί ίς ς μ με ε ρ ρε ευ υμ μα ατ το ολ λο ογ γι ικ κά ά ν νο οσ σή ήμ μα ατ τα α σ στ τη ην ν δ δι ιά άγ γν νω ωσ ση η, , τ τη ην ν π πο ορ ρε εί ία α μ με ετ τά ά λ λή ήψ ψη η ή ή ό όχ χι ι α αν νο οσ σο οκ κα ατ τα ασ στ τα αλ λτ τι ικ κώ ών ν φ φα αρ ρμ μά άκ κω ων ν" " Ι Ιω ωά άν νν νη ης ς Β Β. . Α Ασ ση ημ μα ακ κό όπ πο ου υλ λο ος ς Ι Ια ατ τρ ρό ός ς

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Paroxysmal nocturnal hemoglobinuria as a marker for clonal myelopathy

Graham

Gastineau

1992

The American Journal of Medicine

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Paroxysmal Nocturnal Hemoglobinuria and the Myeloproliferative Syndrome

Cited by 6 publications

References 3 publications

Phenotypic and Transcriptomic Responses of Campylobacter jejuni Suspended in an Artificial Freshwater Medium

Phenotypic and Transcriptomic Responses of Campylobacter jejuni Suspended in an Artificial Freshwater Medium

Μελέτη Των Υποπληθυσμών Ερυθροκυττάρων Τύπου ΝΠΑ Σε Ασθενείς Με Ρευματολογικά Νοσήματα Στην Διάγνωση, Την Πορεία Μετά Λήψη Ή Όχι Ανοσοκατασταλτικών Φαρμάκων

Paroxysmal nocturnal hemoglobinuria as a marker for clonal myelopathy

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