Paroxysmal Kinesigenic Dyskinesia Presented Following Concussion

Cottrill, Norman; McCully, Brian; Payne, Mary

doi:10.14802/jmd.18027

Cited by 2 publications

(3 citation statements)

References 6 publications

(5 reference statements)

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“…Additionally, the onset of dyskinesia in our case was reported to be immediately after the concussive injury, whereas the oromandibular dystonia case by Verma et al described the onset of symptoms three months after the injury. In the case of dyskinesia following concussion, Cottrill et al described a young man who presented with startle myoclonus several months after a concussion [ 7 ]. Although consistent with the current study in the initial insult, the post-concussive sequelae differ drastically [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is little information in the literature detailing a correlation between multiple concussive injuries and the induction of oromandibular dyskinesia [ 6 ]. Furthermore, there is little to no information about chronically sustained oromandibular dyskinesia lasting years after the initial onset of movement was noted [ 7 , 8 ]. Therefore, we present a rare case of concussion-induced chronic oromandibular dyskinesia in a patient with no history of antipsychotic use.…”

Section: Introductionmentioning

confidence: 99%

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Concussion-Induced Oromandibular Dyskinesia

Zhang¹,

Settineri²,

Chajet³

et al. 2023

Cureus

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We present a rare case of concussion-induced chronic oromandibular dyskinesia. The patient is a 51-year-old Caucasian male with complex medical history (including a history of multiple concussions) who presented to the emergency department for suicidal and paranoid ideation. At the time of the visit, the patient was noted to be exhibiting an oromandibular dyskinesia in the form of “teeth-chattering.” The first documented episode of his oromandibular dyskinesia dates back to a medical visit in December 2017. During this visit, the patient presented with teeth-chattering and tremors in his legs, hands, and head after a concussive event. Similar symptoms were noted by two different providers during two unrelated appointments one month later in January 2018. These symptoms were not mentioned in his records for four years and three months following the initial onset. They were noted again during an outpatient encounter for insomnia. During these four years, he was treated for a variety of conditions in both inpatient and outpatient settings, including gout, human immunodeficiency virus (HIV), stage four lymphoma, insomnia, and hepatitis C. Curiously, the dyskinesia symptoms reappeared several months after the completion of six cycles of etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride (R-EPOCH) chemotherapy in May 2021. Since reappearing, the symptoms have been worsening and significantly impacting the patient’s quality of life. Although concussion-induced dyskinesia has been previously described in the literature, this is to our knowledge the first described case of concussion-induced oromandibular dyskinesia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concussion-Induced Oromandibular Dyskinesia

Zhang¹,

Settineri²,

Chajet³

et al. 2023

Cureus

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“…In a few cases, PKD may be secondary to other factors [39], such as demyelinating diseases of the central nervous system, cerebrovascular diseases, traumatic brain injury, or metabolic abnormalities [39][40][41]. Multiple sclerosis (MS), particularly the relapsing-remitting MS, is the most common cause of secondary PKD [42][43][44][45][46].…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Recommendations for the diagnosis and treatment of paroxysmal kinesigenic dyskinesia: an expert consensus in China

Cao¹,

Huang²,

Wang³

et al. 2021

Transl Neurodegener

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Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology. Clinically, PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action. The major cause of primary PKD is genetic abnormalities, and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance. The proline-rich transmembrane protein 2 (PRRT2) was the first identified causative gene of PKD, accounting for the majority of PKD cases worldwide. An increasing number of studies has revealed the clinical and genetic characteristics, as well as the underlying mechanisms of PKD. By seeking the views of domestic experts, we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD. In this consensus, we review the clinical manifestations, etiology, clinical diagnostic criteria and therapeutic recommendations for PKD, and results of genetic analyses in PKD patients performed in domestic hospitals.

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Paroxysmal Kinesigenic Dyskinesia Presented Following Concussion

Cited by 2 publications

References 6 publications

Concussion-Induced Oromandibular Dyskinesia

Concussion-Induced Oromandibular Dyskinesia

Recommendations for the diagnosis and treatment of paroxysmal kinesigenic dyskinesia: an expert consensus in China

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